Lipoteichoic acid of Streptococcus mutans interacts with Toll-like receptor 2 through the lipid moiety for induction of inflammatory mediators in murine macrophages

2014 ◽  
Vol 57 (2) ◽  
pp. 284-291 ◽  
Author(s):  
Sun Woong Hong ◽  
Jung Eun Baik ◽  
Seok-Seong Kang ◽  
Cheol-Heui Yun ◽  
Deog-Gyu Seo ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Inflammatory Mediators ◽  
Lipoteichoic Acid ◽  
Toll Like Receptor ◽  
Murine Macrophages ◽  
Lipid Moiety ◽  
Toll Like Receptor 2

scholarly journals Lipoteichoic Acid and Toll-like Receptor 2 Internalization and Targeting to the Golgi Are Lipid Raft-dependent

2004 ◽  
Vol 279 (39) ◽  
pp. 40882-40889 ◽  
Author(s):  
Martha Triantafilou ◽  
Maria Manukyan ◽  
Alan Mackie ◽  
Siegfried Morath ◽  
Thomas Hartung ◽  
...  
Keyword(s):  
Lipid Raft ◽  
Lipoteichoic Acid ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages

2001 ◽  
Vol 69 (3) ◽  
pp. 1477-1482 ◽  
Author(s):  
Matthew Hirschfeld ◽  
Janis J. Weis ◽  
Vladimir Toshchakov ◽  
Cindy A. Salkowski ◽  
M. Joshua Cody ◽  
...  
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Periodontal Pathogen ◽  
Agonist Activity ◽  
Toll Like Receptor ◽  
Inflammatory Gene Expression ◽  
Murine Macrophages ◽  
Tlr4 Agonist ◽  
Differential Gene ◽  
Toll Like Receptor 2

ABSTRACT Lipopolysaccharide (LPS) derived from the periodontal pathogenPorphyromonas gingivalis has been reported to differ structurally and functionally from enterobacterial LPS. These studies demonstrate that in contrast to protein-free enterobacterial LPS, a similarly purified preparation of P. gingivalis LPS exhibited potent Toll-like receptor 2 (TLR2), rather than TLR4, agonist activity to elicit gene expression and cytokine secretion in murine macrophages and transfectants. More importantly, TLR2 stimulation by this P. gingivalis LPS preparation resulted in differential expression of a panel of genes that are normally induced in murine macrophages by Escherichia coli LPS. These data suggest that (i) P. gingivalis LPS does not signal through TLR4 and (ii) signaling through TLR2 and through TLR4 differs quantitatively and qualitatively. Our data support the hypothesis that the shared signaling pathways elicited by TLR2 and by TLR4 agonists must diverge in order to account for the distinct patterns of inflammatory gene expression.

scholarly journals Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36

2008 ◽  
Vol 84 (1) ◽  
pp. 280-291 ◽  
Author(s):  
Nadra J. Nilsen ◽  
Susanne Deininger ◽  
Unni Nonstad ◽  
Frode Skjeldal ◽  
Harald Husebye ◽  
...  
Keyword(s):  
Lipoteichoic Acid ◽  
Cellular Trafficking ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

A Peptidoglycan-Associated Lipoprotein of Legionella pneumophila Activates Toll-Like Receptor 2 in Murine Macrophages

Legionella ◽  
2014 ◽  
pp. 321-322
Author(s):  
Mi Jeong Kim ◽  
In Kyeong Lee ◽  
Jin-Ah Yang ◽  
Hee-Sun Sim ◽  
Jang Wook Sohn ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Toll Like Receptor ◽  
Murine Macrophages ◽  
Toll Like Receptor 2
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