Impact of l-leucine on controlled release of ciprofloxacin through micellar catalyzed channels in aqueous medium

Tea polyphenol loaded alginate-chitosan microspheres were prepared by ionic gelation method for controlling tea polyphenol release by using various combinations of chitosn and Ca2+ as cation and alginate as anion.Scanning electron microscopy were used to investigate the surface characteristics of tea polyphenol loaded microspheres. These microencapsulated beads were evaluated as a pH-sensitive system for delivery of tea polyphenol. The main advantage of this system is that all procedures used were performed in aqueous medium which may preserve the tea polyphenol bioactivity. At pH7.4, the amounts of tea polyphenol released increased significantly as compared to those released at pH1.2. It is evident that the rate of tea polyphenol release could be controlled by changing the chitosan and the calcium chloride concentrations.

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Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate

Polymers ◽

10.3390/polym13010161 ◽

2021 ◽

Vol 13 (1) ◽

pp. 161

Author(s):

Dorothea Bajas ◽

Gabriela Vlase ◽

Mădălina Mateescu ◽

Oana Alexandra Grad ◽

Mădălin Bunoiu ◽

...

Keyword(s):

Controlled Release ◽

Aqueous Medium ◽

Active Substance ◽

Transdermal Delivery ◽

Spectroscopic Techniques ◽

Carboxylate Group ◽

Group Interactions ◽

Ftir Studies ◽

Membrane Type

The aim of this study is to obtain and characterize of alginate-based membranes, as well as to choose the most suitable membrane type for the transdermal release of methotrexate. The paper presents the synthesis of four types of membranes based on alginate to which are added other copolymers (Carbopol, Tween, and Polyvinylpyrrolidone) as well as other components with different roles. Membranes and binary mixtures made between the components used in membrane synthesis and methotrexate are analyzed by thermogravimetric techniques, FTIR and UV spectroscopic techniques as well as SEM. The analyses aim to establish the type of membrane most indicated in the use of the controlled release of methotrexate, namely those membranes in which there are no interactions that could inactivate the active substance. Following these studies, it was concluded that membranes obtained from alginate/alginate and Tw can be used for methotrexate release. The membrane obtained from alginate and carbopol was excluded from the beginning because it is not homogeneous. Regarding the AGP-MTX membrane, it presents interactions with the active substance, carboxylate group interactions argued by TGA and FTIR studies, and interactions that occur in aqueous medium.

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