scholarly journals Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma

2014 ◽  
Vol 9 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Jin Cheng ◽  
Ling Tian ◽  
Jingjing Ma ◽  
Yanping Gong ◽  
Zhengxiang Zhang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Tumor Cells ◽  
Ductal Adenocarcinoma ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Protein Kinase Cδ

Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells

Biochemistry ◽  
1992 ◽  
Vol 31 (14) ◽  
pp. 3720-3726 ◽  
Author(s):  
Christopher H. Clegg ◽  
Mitchell S. Abrahamsen ◽  
Jay L. Degen ◽  
David R. Morris ◽  
G. Stanley McKnight
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Tumor Cells ◽  
Adrenal Tumor ◽  
Gene Activity ◽  
Dependent Protein Kinase ◽  
Dependent Protein

scholarly journals Sphingosine-dependent Protein Kinase-1, Directed to 14-3-3, Is Identified as the Kinase Domain of Protein Kinase Cδ

2003 ◽  
Vol 278 (42) ◽  
pp. 41557-41565 ◽  
Author(s):  
Akikazu Hamaguchi ◽  
Erika Suzuki ◽  
Kimie Murayama ◽  
Tsutomu Fujimura ◽  
Toshiyuki Hikita ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinase Domain ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Protein Kinase Cδ

scholarly journals A Protein Kinase Cδ-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos

2009 ◽  
Vol 174 (2) ◽  
pp. 449-459 ◽  
Author(s):  
Sylke A. Buder-Hoffmann ◽  
Arti Shukla ◽  
Trisha F. Barrett ◽  
Maximilian B. MacPherson ◽  
Karen M. Lounsbury ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase D ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Protein Kinase Cδ

The roles of cAMP and cAMP-dependent protein kinase in the regulation of adrenocortical functions: analysis using DNA-mediated gene transfer

1986 ◽  
Vol 64 (11) ◽  
pp. 1066-1071 ◽  
Author(s):  
Margaret Wong ◽  
Donalee O'brien ◽  
Bernard P. Schimmer
Keyword(s):  
Protein Kinase ◽  
Gene Transfer ◽  
Tumor Cells ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Adrenocortical Tumor ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Morphological Responses

DNA-mediated gene transfer was used to evaluate the cause and effect relationship between mutations in cAMP-dependent protein kinase activity and cellular resistance of adrenocortical tumor cells to ACTH and cAMP. Protein kinase defective, Kin 8 adrenocortical tumor cells were transformed with genomic DNA from an ACTH- and cAMP-responsive adrenocortical cell line and screened for the recovery of morphological responses to the cAMP analog 8-bromo-cAMP (8BrcAMP). 8BrcAMP-responsive transformants were recovered with a frequency of approximately 0.5 per 103 transformation-competent cells. These transformants recovered the ability to round up in the presence of ACTH and were able to respond to both ACTH and 8BrcAMP with increased steroidogenesis. They also recovered cAMP-dependent protein kinase activity. The transformants, however, were unstable and concomitantly lost cAMP-dependent protein kinase activity and steroidogenic and morphological responses to ACTH and 8BrcAMP. These observations suggest that a single gene, probably the gene encoding the regulatory subunit of cAMP-dependent protein kinase, is responsible for the resistance of the Kin 8 mutant to ACTH and cAMP.

Sign in / Sign up

Export Citation Format

Share Document