Lower melting pharmaceutical cocrystals of metaxalone with carboxamide functionalities

2019 ◽  
Vol 1178 ◽  
pp. 479-490
Author(s):  
SunilKumar V. Gohel ◽  
Palash Sanphui ◽  
Girij Pal Singh ◽  
Krishnamurthy Bhat ◽  
Muthuramalingam Prakash
Keyword(s):  
Pharmaceutical Cocrystals ◽  
Lower Melting

scholarly journals Understanding solid-state processing of pharmaceutical cocrystals via milling: Role of tablet excipients

2021 ◽  
Vol 601 ◽  
pp. 120514 ◽  
Author(s):  
Rahamatullah Shaikh ◽  
Saeed Shirazian ◽  
Sarah Guerin ◽  
Eoin Sheehan ◽  
Damien Thompson ◽  
...  
Keyword(s):  
Solid State ◽  
Pharmaceutical Cocrystals ◽  
Tablet Excipients ◽  
State Processing

scholarly journals Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 671
Author(s):  
Fucheng Leng ◽  
Koen Robeyns ◽  
Tom Leyssens
Keyword(s):  
Ellagic Acid ◽  
Physical Property ◽  
High Humidity ◽  
Pharmaceutical Cocrystals ◽  
Drug Molecules ◽  
Temperature Environment ◽  
Pharmaceutical Cocrystal ◽  
The Stability ◽  
As Solubility ◽  
High Temperature Environment

Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc. The pharmaceutical industry is particularly interested in those cocrystals comprising a GRAS former in connection with the target API. In this work, we focus on the potential of urea as a cocrystal former, identifying three novel pharmaceutical cocrystal systems with catechin, 3-hydroxyl-2-naphthoic and ellagic acid. Interestingly, the stability of catechin under high humidity or high temperature environment is improved upon cocrystallization with urea. Moreover, the solubility of ellagic acid is improved about 17 times. This work displays the latent possibility of urea in improving the physical property of drug molecules using a cocrystallization approach.

Pharmaceutical cocrystals of nitrofurantoin: screening, characterization and crystal structure analysis

CrystEngComm ◽  
2012 ◽  
Vol 14 (15) ◽  
pp. 5078 ◽  
Author(s):  
Amjad Alhalaweh ◽  
Sumod George ◽  
Srinivas Basavoju ◽  
Scott L. Childs ◽  
Syed A. A. Rizvi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Pharmaceutical Cocrystals

Pharmaceutical cocrystals: An overview

2011 ◽  
Vol 419 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Ning Qiao ◽  
Mingzhong Li ◽  
Walkiria Schlindwein ◽  
Nazneen Malek ◽  
Angela Davies ◽  
...  
Keyword(s):  
Pharmaceutical Cocrystals

scholarly journals Coprocessing of Pharmaceutical Cocrystals for High Quality and Enhanced Physicochemical Stability

2018 ◽  
Vol 19 (2) ◽  
pp. 876-888 ◽  
Author(s):  
Steven A. Ross ◽  
Adam Ward ◽  
Pat Basford ◽  
Mark McAllister ◽  
Dennis Douroumis
Keyword(s):  
High Quality ◽  
Pharmaceutical Cocrystals ◽  
Physicochemical Stability

Early alterations in rat liver chromatin structure after a single dose of diethylnitrosamine

1983 ◽  
Vol 3 (2) ◽  
pp. 185-188
Author(s):  
Karl Letnansky ◽  
Hratschik R. Vardapetjan
Keyword(s):  
Single Dose ◽  
Rat Liver ◽  
Chromatin Structure ◽  
Chemical Modifications ◽  
Lower Melting ◽  
Melting Temperatures ◽  
Liver Chromatin ◽  
Rat Livers ◽  
Rapid Shift ◽  
Good Agreement

In the chromatin of 24-h regenerating rat livers, derivative melting profiles are characterized by a high proportion of transitions above 90°C. After the injection of diethylnitrosamine there is a rapid shift to lower melting temperatures. This is due to a rearrangement of the chromatin to higher amounts of nucleosomal components but possibly also a consequence of chemical modifications and conformational alterations of the DNA. In the nonregenerating liver essentially the same observations can be made, although reactions proceed significantly slower. These results are in good agreement with the observation that carcinogens are more active in tissues stimulated to rapid proliferation as compared to resting tissues.

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