Synthesis, structural characterization and biological activities of transition metal complexes derived from 2,4-dihydroxybenzaldehyde n(4)-methyl(phenyl)thiosemicarbazone

The synthesis and structural characterization of a square-planar copper(II) complex with pyridoxal S-methylisothiosemicarbazone (PLITSC) of the formula [Cu(PLITSC?H)H2O]Br?H2O (1) as the first Cu(II) complex with monoanionic form of this ligand were described. Complex 1 together with two previously synthesized complexes [Cu(PLITSC)Br2] (2) and [Cu(PLITSC)Br(MeOH)]Br (3) were characterized by elemental analysis, IR and electronic spectra and also by the methods of thermal analysis, conductometry and magnetochemistry.

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Transition-metal complexes with sulfur atom as ligand. 2. Synthesis, properties, and structural characterization of thio, mercapto, and methylthio complexes of cobalt(I) and nickel(I) and -(II) with poly(tertiary phosphines)

Inorganic Chemistry ◽

10.1021/ic50181a023 ◽

1978 ◽

Vol 17 (3) ◽

pp. 632-637 ◽

Cited By ~ 59

Author(s):

Carlo Mealli ◽

Stefano Midollini ◽

Luigi Sacconi

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Sulfur Atom ◽

Structural Characterization ◽

Tertiary Phosphines ◽

Synthesis Properties

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Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes

Molecules ◽

10.3390/molecules25153492 ◽

2020 ◽

Vol 25 (15) ◽

pp. 3492

Author(s):

Katarzyna Gałczyńska ◽

Zuzanna Drulis-Kawa ◽

Michał Arabski

Keyword(s):

Cell Cycle ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Antitumor Agents ◽

Current Knowledge ◽

Biological Activities ◽

Chemical Compounds ◽

Cell Cycle Inhibition ◽

Therapeutic Compounds

Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.

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Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22703 ◽

2020 ◽

Vol 32 (7) ◽

pp. 1768-1772

Author(s):

Anita Rani ◽

Manoj Kumar ◽

Hardeep Singh Tuli ◽

Zahoor Abbas ◽

Vinit Prakash

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Schiff Base Ligand ◽

Biological Activities ◽

Condensation Reaction ◽

Analytical Techniques ◽

Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

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