Fabrication of KDF-loaded chitosan-oligosaccharide-encapsulated konjac glucomannan/sodium alginate/zeolite P microspheres with sustained-release antimicrobial activity

Objective: The objective of this research work is to develop and evaluate mucoadhesive microspheres of an anti-migraine drug for sustained release. Materials and Methods: Mucoadhesive microspheres were prepared by emulsification method using Sodium alginate (SA), polyvinyl pyrrolidone (PVP) and Chitosan in the various drug-polymer ratios of 1:1, 1:2 and 1:3. Nine formulations were formulated and evaluated for possible drug polymer interactions, percentage yield, micromeritic properties, particle size, drug content, drug entrapment efficiency, drug loading, swelling index, In-vitro wash off test, in vitro drug release, surface morphology and release kinetics. Results: The results showed that no significant drug polymer interaction in FTIR studies. Among all the formulations SF3 containing sodium alginate showed 77.18% drug release in 6hrs. Conclusion: Amongst the developed mucoadhesive microspheres, SF3 formulation containing sodium alginate exhibited slow and sustained release in a controlled manner and it is a promising formulation for sustained release of Sumatriptan succinate. Keywords: Mucoadhesive microspheres, Sodium alginate, polyvinyl pyrrolidone, Chitosan, sustained release.

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Studies on macromolecular interactions in ternary mixtures of konjac glucomannan, xanthan gum and sodium alginate

Carbohydrate Polymers ◽

10.1016/j.carbpol.2010.06.035 ◽

2011 ◽

Vol 83 (2) ◽

pp. 329-338 ◽

Cited By ~ 37

Author(s):

Stephen E. Harding ◽

Ian H. Smith ◽

Christopher J. Lawson ◽

Roland J. Gahler ◽

Simon Wood

Keyword(s):

Sodium Alginate ◽

Xanthan Gum ◽

Konjac Glucomannan ◽

Ternary Mixtures ◽

Macromolecular Interactions

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Sustained Release Liquid Preparation Using Sodium Alginate for Eradication of Helicobacter pyroli.

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.22.55 ◽

1999 ◽

Vol 22 (1) ◽

pp. 55-60 ◽

Cited By ~ 29

Author(s):

Hirokazu KATAYAMA ◽

Takeya NISHIMURA ◽

Satoru OCHI ◽

Yasuto TSURUTA ◽

Yuriko YAMAZAKI ◽

...

Keyword(s):

Sustained Release ◽

Sodium Alginate ◽

Liquid Preparation

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Evaluation of a Matrix Tablet Prepared with Polyacrylamide-g-Sodium Alginate Co-polymers and Their Partially Hydrolyzed Co-polymers for Sustained Release of Diltiazem Hydrochloride

Journal of Biomaterials Science Polymer Edition ◽

10.1163/092050609x12567183711214 ◽

2010 ◽

Vol 21 (13) ◽

pp. 1799-1814 ◽

Cited By ~ 1

Author(s):

Sanchita Mandal ◽

Rajat Ray ◽

Sanat K. Basu ◽

Biswanath Sa

Keyword(s):

Sustained Release ◽

Sodium Alginate ◽

Matrix Tablet ◽

Diltiazem Hydrochloride

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Synthesis, Characterization, and Antimicrobial Activity of Kojic Acid Grafted Chitosan Oligosaccharide

Journal of Agricultural and Food Chemistry ◽

10.1021/jf404026f ◽

2013 ◽

Vol 62 (1) ◽

pp. 297-303 ◽

Cited By ~ 57

Author(s):

Xiaoli Liu ◽

Wenshui Xia ◽

Qixing Jiang ◽

Yanshun Xu ◽

Peipei Yu

Keyword(s):

Antimicrobial Activity ◽

Kojic Acid ◽

Chitosan Oligosaccharide

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Formulation and Evaluation of Acyclovir Microspheres

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) ◽

10.31351/vol27iss1pp1-7 ◽

2018 ◽

Vol 27 (1) ◽

pp. 1-7

Author(s):

Pavani S ◽

Mounika K ◽

Naresh K

Keyword(s):

Particle Size ◽

Sustained Release ◽

Sodium Alginate ◽

Calcium Chloride ◽

Polymer Concentration ◽

Entrapment Efficiency ◽

In Vitro Dissolution ◽

Release Mechanism ◽

Natural Polymers

The present study is to formulate and evaluate Acyclovir (ACV) microspheres using natural polymers like chitosan and sodium alginate. ACV is a DNA polymerase inhibitor used in treating herpes simplex virus infection and zoster varicella infections. Acyclovir is a suitable candidate for sustained-release (SR) administration as a result of its dosage regimen twice or thrice a day and relatively short plasma half-life (approximately 2 to 4 hours). Microspheres of ACV were prepared by an ionic dilution method using chitosan and sodium alginate as polymers. The prepared ACV microspheres were then subjected to FTIR, SEM, particle size, % yield, entrapment efficiency, in vitro dissolution studies and release kinetics mechanism. The FTIR spectra’s revealed that, there was no interaction between polymer and ACV. ACV microspheres were spherical in nature, which was confirmed by SEM. The particle size of microspheres was in the range of 23.8µm to 39.4µm. 72.9% drug entrapment efficiency was obtained in the formulation F3 (1:3 ratio) with a high concentration of calcium chloride (4% w/v). The in vitro performance of ACV microspheres showed sustained release depending on the polymer concentration and concentration of calcium chloride. The release data was best fitted with zero order kinetics and Korsemeyer -Peppas release mechanism and diffusion exponent ‘n’ value of was found to be Non-Fickian.

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