Studies on macromolecular interactions in ternary mixtures of konjac glucomannan, xanthan gum and sodium alginate

The aim of the present work was to prepare floating tablets of galantamine HBr using sodium alginate and xanthan gum as matrix forming carriers. Galantamine HBr is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. The matrix tablet formulations were prepared by varying the concentrations of sodium alginate and xanthan gum. The tablets were prepared by direct compression technique using PVP K-30 as a binder and sodium bicarbonate for development of CO2. The prepared matrix tablets were evaluated for properties such as hardness, thickness, friability, weight variation, floating lag time, compatibility using DSC and FTIR. In vitro dissolution was carried out for 12 hrs in 0.1N HCl at 37±0.5 ºC using USP paddle type dissolution apparatus. It was noted that, all the prepared formulations had desired floating lag time and constantly floated on dissolution medium by maintaining the matrix integrity. The drug release from prepared tablets was found to vary with varying concentration of the polymers, sodium alginate and xanthan gum. From the study it was concluded that floating drug delivery system for galantamine HBr can be prepared by using sodium alginate and xanthan gum as a carrier.

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Konjac glucomannan/xanthan gum enzyme sensitive binary mixtures for colonic drug delivery

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2008.01.004 ◽

2008 ◽

Vol 69 (2) ◽

pp. 573-581 ◽

Cited By ~ 35

Author(s):

Felipe Alvarez-Manceñido ◽

Mariana Landin ◽

Ramón Martínez-Pacheco

Keyword(s):

Drug Delivery ◽

Binary Mixtures ◽

Xanthan Gum ◽

Konjac Glucomannan ◽

Colonic Drug Delivery

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FORMULATION OF AN ANTI-WRINKLE HYDROGEL FACE MASK CONTAINING ETHANOL EXTRACT OF NONI FRUIT (MORINDA CITRIFOLIA L) FOR USE AS A NUTRACOSMECEUTICAL PRODUCT

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2017.v9s1.41_47 ◽

2017 ◽

Vol 9 ◽

pp. 74 ◽

Cited By ~ 1

Author(s):

Silvia Surini ◽

Annisa Auliyya

Keyword(s):

Tensile Strength ◽

Sodium Alginate ◽

Ursolic Acid ◽

Xanthan Gum ◽

Physical Stability ◽

Ethanol Extract ◽

Face Mask ◽

Skin Care ◽

Morinda Citrifolia ◽

Water Holding

Objectives: Noni fruit (Morinda citrifolia L) containing ursolic acid and 3,3’ bisdemethylpinoresinol can be useful as an anti-wrinkle agent. Thehydrogel face mask is an alternative skin care product.Methods: In this study, 0.1% ethanol extract of noni fruit was formulated with a concentration of 4% sodium alginate and 0.5% xanthan gum to formthe hydrogel face mask. Physical stability of the hydrogel face mask was evaluated using organoleptic observation, consistency rates, swelling indexmeasurements, and mechanical strength.Results: The results showed that the hydrogel face mask has good water holding capacity, a tensile strength of 35.6524±0.8842 kgf/cm2, an elongationrate of 272.00±4.47%, and remains stable in color and odor for 12 weeks.Conclusions: This study revealed that the hydrogel face mask containing an ethanol extract of noni fruit is stable and has good physical characteristics;therefore, the hydrogel face mask is satisfactory for use as a nutracosmeceutical product.

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FORMULATION AND EVALUATION OF FENOVERINE FLOATING TABLETS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i4.40999 ◽

2021 ◽

pp. 175-180

Author(s):

RASHMITHA V ◽

MADHUSUDAN RAO Y ◽

PAVANI S

Keyword(s):

Sodium Alginate ◽

Xanthan Gum ◽

In Vitro Release ◽

Angle Of Repose ◽

In Vitro Dissolution ◽

Release Time ◽

Floating Tablets ◽

Dissolution Studies ◽

Weight Variation

Objective: The purpose of this research was to develop a fenoverine gastroretentive drug delivery system which, following oral administration should have the ability to enhance and prolong the period of gastric residence time (GRD) with the desired in vitro release profile. Methods: In the present study, fenoverine floating tablets were prepared using an effervescent method using sodium bicarbonate and citric acid as a gas-generating agent. The tablets were formulated using direct compression technology using xanthan gum and sodium alginate as polymers. Pre-compression powders were evaluated for angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio, and the prepared tablets were evaluated for weight variation, thickness, diameter, hardness, friability, drug content, floating lag time, total floating time, and in vitro dissolution studies. The formulations were optimized for the different concentrations of xanthan gum, sodium alginate, and their combinations. Results: All the prepared formulations showed well in vitro buoyancy. The tablets remained buoyant for 6–12 h. The in vitro drug-release pattern of fenoverine floating tablets was adapted to different kinetic models with the highest regression to zero-order and Korsmeyer-Peppas, and the mechanism was found to be a Fickian mechanism. Conclusion: Out of all the formulations prepared, in vitro dissolution studies of the F4 formulation were found to be maximum than other batches, which exhibited desired sustained release time followed by acceptable floating properties.

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Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing

Polymers ◽

10.3390/polym12010099 ◽

2020 ◽

Vol 12 (1) ◽

pp. 99 ◽

Cited By ~ 1

Author(s):

Andreia Alves ◽

Sónia P. Miguel ◽

André R.T.S. Araujo ◽

María José de Jesús Valle ◽

Amparo Sánchez Navarro ◽

...

Keyword(s):

Xanthan Gum ◽

Biomedical Application ◽

Three Dimensional ◽

High Water ◽

Biological Properties ◽

Konjac Glucomannan ◽

Wound Dressings ◽

Dimensional Structure ◽

Future Application ◽

High Water Content

Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application. From the best of our knowledge, the application of a xanthan gum–konjac glucomannan blend has not been used for the production of wound dressings. Herein, a thermo-reversible hydrogel composed of xanthan gum–konjac glucomannan (at different concentrations (1% and 2% w/v) and ratios (50/50 and 60/40)) was produced and characterized. The obtained data emphasize the excellent physicochemical and biological properties of the produced hydrogels, which are suitable for their future application as wound dressings.

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