Sustained Release of Verapamil Hydrochloride from Sodium Alginate Microcapsules

2010 ◽  
Vol 7 (2) ◽  
pp. 98-108 ◽  
Author(s):  
S. Ayesha Farhana ◽  
S. M. Shantakumar ◽  
Somashekar Shyale ◽  
Md. Shalam ◽  
Laxmi Narasu
Keyword(s):  
Sustained Release ◽  
Sodium Alginate ◽  
Verapamil Hydrochloride

In Vitro Release Study of Verapamil Hydrochloride Through Sodium Alginate Interpenetrating Monolithic Membranes

2001 ◽  
Vol 27 (10) ◽  
pp. 1107-1114 ◽  
Author(s):  
Mahaveer D. Kurkuri ◽  
Anandrao R. Kulkarni ◽  
Mahadevappa Y. Kariduraganavar ◽  
Tejraj M. Aminabhavi
Keyword(s):  
Sodium Alginate ◽  
In Vitro Release ◽  
Verapamil Hydrochloride ◽  
Release Study ◽  
Vitro Release

scholarly journals FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF AN ANTI-MIGRAINE DRUG

2018 ◽  
Vol 8 (5) ◽  
pp. 465-474
Author(s):  
S PADMA PRIYA ◽  
AN Rajalakshmi ◽  
P Ilaveni
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Sodium Alginate ◽  
Release Kinetics ◽  
Drug Loading ◽  
Research Work ◽  
Entrapment Efficiency ◽  
Polyvinyl Pyrrolidone ◽  
Anti Migraine Drug

Objective: The objective of this research work is to develop and evaluate mucoadhesive microspheres of an anti-migraine drug for sustained release. Materials and Methods:  Mucoadhesive microspheres were prepared by emulsification method using Sodium alginate (SA), polyvinyl pyrrolidone (PVP) and Chitosan in the various drug-polymer ratios of 1:1, 1:2 and 1:3. Nine  formulations were formulated and  evaluated for  possible drug polymer interactions, percentage yield, micromeritic properties, particle size, drug content, drug entrapment efficiency, drug loading, swelling index, In-vitro wash off test, in vitro  drug release, surface morphology and release kinetics. Results: The results showed that no significant drug polymer interaction in FTIR studies. Among all the formulations SF3 containing sodium alginate showed 77.18% drug release in 6hrs. Conclusion: Amongst the developed mucoadhesive microspheres, SF3 formulation containing sodium alginate exhibited slow and sustained release in a controlled manner and it is a promising formulation for sustained release of Sumatriptan succinate. Keywords: Mucoadhesive microspheres, Sodium alginate, polyvinyl pyrrolidone, Chitosan, sustained release.

Novel Chewable Sustained‐Release Tablet Containing Verapamil Hydrochloride

2004 ◽  
Vol 9 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Omaima N. El‐Gazayerly ◽  
Vipaporn Rakkanka ◽  
James W. Ayres
Keyword(s):  
Sustained Release ◽  
Verapamil Hydrochloride ◽  
Sustained Release Tablet ◽  
Release Tablet

scholarly journals Sustained Release Liquid Preparation Using Sodium Alginate for Eradication of Helicobacter pyroli.

1999 ◽  
Vol 22 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Hirokazu KATAYAMA ◽  
Takeya NISHIMURA ◽  
Satoru OCHI ◽  
Yasuto TSURUTA ◽  
Yuriko YAMAZAKI ◽  
...  
Keyword(s):  
Sustained Release ◽  
Sodium Alginate ◽  
Liquid Preparation

scholarly journals New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride

2007 ◽  
Vol 57 (4) ◽  
pp. 429-439
Author(s):  
Bistra Kostova ◽  
Dimitar Rachev
Keyword(s):  
Drug Delivery ◽  
Ionic Strength ◽  
Sustained Release ◽  
Vinyl Acetate ◽  
Swelling Kinetics ◽  
Verapamil Hydrochloride ◽  
Emulsion Copolymerization ◽  
Sustained Drug Delivery ◽  
First Time ◽  
Unit Fraction

New co-polymer zwitterionic matrices for sustained release of verapamil hydrochlorideStable co-polymer [vinyl acetate-co-3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate, p(VA-co-DMAPS)] latex of different compositions has been synthesized for the first time by emulsifier-free emulsion copolymerization. The unusual >>overshooting<< behavior of the co-polymer tablets has been explained by the formation of specific clusters from the opposite oriented dipoles-zwitterionic species. The change of their concentration with the DMAPS unit fraction (mDMAPS), pH and ionic strength has been considered responsible for the differences observed in the swelling kinetics. The results obtained prove that mDMAPSand ionic strength could be used to control the swelling degree of the p(VA-co-DMAPS) matrices and their sustained drug delivery. In this way, p(VA-co-DMAPS) matrices could be effectively used to control the sustained release of drugs with basic properties like verapamil hydrochloride from model tablets.

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