Sustained Release Liquid Preparation Using Sodium Alginate for Eradication of Helicobacter pyroli.

Objective: The objective of this research work is to develop and evaluate mucoadhesive microspheres of an anti-migraine drug for sustained release. Materials and Methods: Mucoadhesive microspheres were prepared by emulsification method using Sodium alginate (SA), polyvinyl pyrrolidone (PVP) and Chitosan in the various drug-polymer ratios of 1:1, 1:2 and 1:3. Nine formulations were formulated and evaluated for possible drug polymer interactions, percentage yield, micromeritic properties, particle size, drug content, drug entrapment efficiency, drug loading, swelling index, In-vitro wash off test, in vitro drug release, surface morphology and release kinetics. Results: The results showed that no significant drug polymer interaction in FTIR studies. Among all the formulations SF3 containing sodium alginate showed 77.18% drug release in 6hrs. Conclusion: Amongst the developed mucoadhesive microspheres, SF3 formulation containing sodium alginate exhibited slow and sustained release in a controlled manner and it is a promising formulation for sustained release of Sumatriptan succinate. Keywords: Mucoadhesive microspheres, Sodium alginate, polyvinyl pyrrolidone, Chitosan, sustained release.

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Evaluation of a Matrix Tablet Prepared with Polyacrylamide-g-Sodium Alginate Co-polymers and Their Partially Hydrolyzed Co-polymers for Sustained Release of Diltiazem Hydrochloride

Journal of Biomaterials Science Polymer Edition ◽

10.1163/092050609x12567183711214 ◽

2010 ◽

Vol 21 (13) ◽

pp. 1799-1814 ◽

Cited By ~ 1

Author(s):

Sanchita Mandal ◽

Rajat Ray ◽

Sanat K. Basu ◽

Biswanath Sa

Keyword(s):

Sustained Release ◽

Sodium Alginate ◽

Matrix Tablet ◽

Diltiazem Hydrochloride

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Formulation and Evaluation of Acyclovir Microspheres

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) ◽

10.31351/vol27iss1pp1-7 ◽

2018 ◽

Vol 27 (1) ◽

pp. 1-7

Author(s):

Pavani S ◽

Mounika K ◽

Naresh K

Keyword(s):

Particle Size ◽

Sustained Release ◽

Sodium Alginate ◽

Calcium Chloride ◽

Polymer Concentration ◽

Entrapment Efficiency ◽

In Vitro Dissolution ◽

Release Mechanism ◽

Natural Polymers

The present study is to formulate and evaluate Acyclovir (ACV) microspheres using natural polymers like chitosan and sodium alginate. ACV is a DNA polymerase inhibitor used in treating herpes simplex virus infection and zoster varicella infections. Acyclovir is a suitable candidate for sustained-release (SR) administration as a result of its dosage regimen twice or thrice a day and relatively short plasma half-life (approximately 2 to 4 hours). Microspheres of ACV were prepared by an ionic dilution method using chitosan and sodium alginate as polymers. The prepared ACV microspheres were then subjected to FTIR, SEM, particle size, % yield, entrapment efficiency, in vitro dissolution studies and release kinetics mechanism. The FTIR spectra’s revealed that, there was no interaction between polymer and ACV. ACV microspheres were spherical in nature, which was confirmed by SEM. The particle size of microspheres was in the range of 23.8µm to 39.4µm. 72.9% drug entrapment efficiency was obtained in the formulation F3 (1:3 ratio) with a high concentration of calcium chloride (4% w/v). The in vitro performance of ACV microspheres showed sustained release depending on the polymer concentration and concentration of calcium chloride. The release data was best fitted with zero order kinetics and Korsemeyer -Peppas release mechanism and diffusion exponent ‘n’ value of was found to be Non-Fickian.

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Fabrication and characterization of biocompatible pH responsive halloysite nanotubes grafted with sodium alginate for sustained release of phenytoin sodium

New Journal of Chemistry ◽

10.1039/c9nj00976k ◽

2019 ◽

Vol 43 (26) ◽

pp. 10523-10530 ◽

Cited By ~ 8

Author(s):

Leila Zeraatpishe ◽

Alireza Mohebali ◽

Majid Abdouss

Keyword(s):

Controlled Release ◽

Sustained Release ◽

Sodium Alginate ◽

Halloysite Nanotubes ◽

Ph Sensitive ◽

New Method ◽

Ph Responsive ◽

Phenytoin Sodium ◽

Fabrication And Characterization

Schematic design of a new method for fabrication of biocompatible pH sensitive halloysite nanocomposites for controlled release of phenytoin sodium.

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Formulation and Evaluation of Sustained Release Floating Tablets of an Antihypertensive Diltiazem

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2017.10.5.5 ◽

2017 ◽

Vol 10 (5) ◽

pp. 3844-3852

Author(s):

Gururaj S Kulkarni ◽

Prabhansh P Chaudhary ◽

Shivakumar Swamy

Keyword(s):

Drug Release ◽

Sustained Release ◽

Sodium Alginate ◽

Angle Of Repose ◽

Polymeric Chain ◽

Release Mechanism ◽

Natural Polymers ◽

Floating Tablets ◽

Higuchi Model

The aim of the present study was to develop and evaluate sustained release floating tablets of Diltiazem hydro-chloride, an antihypertensive agent. The sustained release floating tablets were prepared by direct compression method and formulated using different polymer combinations, formulations such as F1 to F9. Natural polymer Sodium alginate and synthetic polymer HPMC K4M were used. Developed formulations were evaluated for the pre compression parameters i.e., drug- excipients compatibility by FTIR, bulk density, compressibility, and angle of repose etc. Post compression parameters i.e. weight variation; full factorial design was applied to optimize the developed formulation. SA and HPMC K4M were selected as independent variable at three different concentrations. The in-vitro drug release study revealed that formulation F8 combination of both synthetic (HPMC) and natural polymers (sodium alginate) was the most successful formulation of the study, all tablets but one exhibited gradual and near complete sustained release for diltiazem HCl (90-100%) that extended the drug release up to 8 hours, with satisfactory drug release in the initial hours, and the total release pattern was close to the theoretical release profile. Model equations of zero and first order, Higuchi, Hixson-Crowell and Peppas, intended to elucidate the drug release mechanism, and were fitted to the release data. Mathematical modelling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with Higuchi model with r2 vales of 0.994 in its semi log plot. The ‘n’ value in Higuchi model was >0.89 which indicated, Super Case-II transport of drug from polymer sustained, i.e., diffusion with relaxation of polymeric chain. In conclusion, the results indicated that the prepared sustained-release tablets of Diltiazem hydrochloride could perform therapeutically better than conventional tablets with improved efficacy and better patient compliance.

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