Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease

2009 ◽  
Vol 667 (1-2) ◽  
pp. 77-81 ◽  
Author(s):  
Chih-Ching Yeh ◽  
Fung-Chang Sung ◽  
Li-Tang Kuo ◽  
Wan-Ping Hsu ◽  
Hsiang-Yu Chu
Keyword(s):  
Coronary Artery Disease ◽  
Cytochrome P450 ◽  
Coronary Artery ◽  
Cigarette Smoking ◽  
Cytochrome P450 1A1 ◽  
Artery Disease

scholarly journals Relationship between rs854560PON1Gene Polymorphism and Tobacco Smoking with Coronary Artery Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Joanna Iwanicka ◽  
Tomasz Iwanicki ◽  
Paweł Niemiec ◽  
Tomasz Nowak ◽  
Jolanta Krauze ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cigarette Smoking ◽  
Relative Increase ◽  
Paraoxonase 1 ◽  
High Density Lipoproteins ◽  
Polish Population ◽  
Premature Cad ◽  
Traditional Risk Factors ◽  
Artery Disease

Paraoxonase-1 (PON1) is the antioxidant marker of high-density lipoproteins protecting against atherosclerosis and coronary artery disease (CAD) phenotype. The purpose of the present study was to determine whether thePON1gene rs854560 polymorphism (163T>A) is associated with CAD in Polish population. rs854560 was genotyped in 494 subjects: 248 patients with premature CAD and 246 blood donors as a control. We found that the risk of CAD was significantly higher in TT homozygotes than in A allele carriers (OR = 1.87,p=0.041). The synergistic effect between the TT genotype and cigarette smoking was observed (SIM = 9.81; SI = 14.70). The relative increase in risk from interaction between factors was over 37 (RERI = 36.13). ThePON1polymorphism did not modulate the risk of CAD in response to exposure to other traditional risk factors. In conclusion, the rs854560 polymorphism may modulate the risk of CAD in response to cigarette smoking in Polish population. Carriers of TT genotype seem to be particularly at risk of CAD, when exposed to cigarette smoking.

scholarly journals Cigarette smoking and non-fatal myocardial infarction in women: is the relation independent of coronary artery disease?

Heart ◽  
1989 ◽  
Vol 62 (4) ◽  
pp. 273-280 ◽  
Author(s):  
D S Freedman ◽  
H W Gruchow ◽  
J A Walker ◽  
S J Jacobsen ◽  
A J Anderson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cigarette Smoking ◽  
Artery Disease ◽  
Fatal Myocardial Infarction

scholarly journals Risk of Coronary Artery Disease Associated With Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2

Circulation ◽  
2004 ◽  
Vol 110 (15) ◽  
pp. 2132-2136 ◽  
Author(s):  
Martin Spiecker ◽  
Harald Darius ◽  
Thomas Hankeln ◽  
Muhidien Soufi ◽  
Alexander M. Sattler ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cytochrome P450 ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study

2015 ◽  
Vol 57 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Akinyemi Oni-Orisan ◽  
Matthew L. Edin ◽  
John Andrew Lee ◽  
Michael A. Wells ◽  
Erin S. Christensen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cytochrome P450 ◽  
Coronary Artery ◽  
Epoxyeicosatrienoic Acids ◽  
Targeted Metabolomics ◽  
Metabolomics Study ◽  
Artery Disease

Cigarette smoking and inflammatory indices in coronary artery disease

2004 ◽  
Vol 93 (2-3) ◽  
pp. 169-174 ◽  
Author(s):  
Katarzyna Mizia-Stec ◽  
Barbara Zahorska-Markiewicz ◽  
Zbigniew Gąsior
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cigarette Smoking ◽  
Artery Disease
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