Evaluation of antiangiogenic treatment effects on tumors' microcirculation by Bayesian physiological pharmacokinetic modeling and magnetic resonance imaging

2006 ◽  
Vol 24 (8) ◽  
pp. 1059-1067 ◽  
Author(s):  
Céline Brochot ◽  
Bertrand Bessoud ◽  
Daniel Balvay ◽  
Charles-André Cuénod ◽  
Nathalie Siauve ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Treatment Effects ◽  
Pharmacokinetic Modeling ◽  
Resonance Imaging ◽  
Antiangiogenic Treatment

Magnetic Resonance Imaging for Assessment of Treatment Effects in Mediastinal Hodgkin's Disease

1987 ◽  
Vol 28 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Rickard Nyman ◽  
S. Rehn ◽  
B. Glimelius ◽  
H. Hagberg ◽  
A. Hemmingsson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Hodgkin's Disease ◽  
Treatment Effects ◽  
Hodgkin’S Disease ◽  
Resonance Imaging ◽  
Assessment Of Treatment Effects

Prediction of Antiangiogenic Treatment Efficacy by Iron Oxide Enhanced Parametric Magnetic Resonance Imaging

2007 ◽  
Vol 42 (12) ◽  
pp. 791-796 ◽  
Author(s):  
Thorsten Persigehl ◽  
Lars Matuszewski ◽  
Torsten Kessler ◽  
Alexander Wall ◽  
Norbert Meier ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Treatment Efficacy ◽  
Resonance Imaging ◽  
Antiangiogenic Treatment

scholarly journals Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Pharmacokinetic Modeling: Initial Experience in Patients With Early Arthritis

2016 ◽  
Vol 68 (3) ◽  
pp. 587-596 ◽  
Author(s):  
Karen I. Maijer ◽  
Christiaan van der Leij ◽  
Maria J. H. de Hair ◽  
Sander W. Tas ◽  
Mario Maas ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Pharmacokinetic Modeling ◽  
Early Arthritis ◽  
Initial Experience ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Integrin αvβ3–Targeted Dynamic Contrast–Enhanced Magnetic Resonance Imaging Using a Gadolinium-Loaded Polyethylene Gycol–Dendrimer–Cyclic RGD Conjugate to Evaluate Tumor Angiogenesis and to Assess Early Antiangiogenic Treatment Response in a Mouse Xenograft Tumor Model

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00050 ◽  
Author(s):  
Wei-Tsung Chen ◽  
Tiffany Ting Fang Shih ◽  
Ran-Chou Chen ◽  
Shin-Yang Tu ◽  
Hsieh Wen-Yuen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Angiogenesis ◽  
Antiangiogenic Therapy ◽  
Resonance Imaging ◽  
Antiangiogenic Treatment ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Bevacizumab Treatment ◽  
Contrast Enhanced

The purpose of this study was to validate an integrin αvβ3–targeted magnetic resonance contrast agent, PEG-G3-(Gd-DTPA)6-(cRGD-DTPA)2, for its ability to detect tumor angiogenesis and assess early response to antiangiogenic therapy using dynamic contrast–enhanced (DCE) magnetic resonance imaging (MRI). Integrin αvβ3–positive U87 cells and control groups were incubated with fluorescein-labeled cRGD-conjugated dendrimer, and the cellular attachment of the dendrimer was observed. DCE MRI was performed on mice bearing KB xenograft tumors using either PEG-G3-(Gd-DTPA)6-(cRGD-DTPA)2 or PEG-G3-(Gd-DTPA)6-(cRAD-DTPA)2. DCE MRI was also performed 2 hours after anti–integrin αvβ3 monoclonal antibody treatment and after bevacizumab treatment on days 3 and 6t. Using DCE MRI, the 30-minute contrast washout percentage was significantly lower in the cRGD-conjugate injection groups. The enhancement patterns were different between the two contrast injection groups. In the antiangiogenic therapy groups, a rapid increase in 30-minute contrast washout percentage was observed in both the LM609 and bevacizumab treatment groups, and this occurred before there was an observable decrease in tumor size. The integrin αvβ3 targeting ability of PEG-G3-(Gd-DTPA)6-(cRGD-DTPA)2 in vitro and in vivo was demonstrated. The 30-minute contrast washout percentage is a useful parameter for examining tumor angiogenesis and for the early assessment of antiangiogenic treatment response.

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