Evaluation of discrete orthogonal versus polar Stockwell Transform for local multi-resolution texture analysis using brain MRI of multiple sclerosis patients

The aim of the study was to verify the association of clinical relapses and brain activity with disability progression in relapsing/remitting multiple sclerosis patients receiving disease-modifying treatments in Poland. Disability progression was defined as relapse-associated worsening (RAW), progression independent of relapse activity (PIRA), and progression independent of relapses and brain MRI Activity (PIRMA). Data from the Therapeutic Program Monitoring System were analyzed. Three panels of patients were identified: R0, no relapse during treatment, and R1 and R2 with the occurrence of relapse during the first and the second year of treatment, respectively. In the R0 panel, we detected 4.6% PIRA patients at 24 months (p < 0.001, 5.0% at 36 months, 5.6% at 48 months, 6.1% at 60 months). When restricting this panel to patients without brain MRI activity, we detected 3.0% PIRMA patients at 12 months, 4.5% at 24 months, and varying from 5.3% to 6.2% between 36 and 60 months of treatment, respectively. In the R1 panel, RAW was detected in 15.6% patients at 12 months and, in the absence of further relapses, 9.7% at 24 months and 6.8% at 36 months of treatment. The R2 group was associated with RAW significantly more frequently at 24 months compared to the R1 at 12 months (20.7%; p < 0.05), but without a statistical difference later on. In our work, we confirmed that disability progression was independent of relapses and brain MRI activity.

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Patterns of disease activity in multiple sclerosis patients: A study with quantitative gadolinium-enhanced brain MRI and cytokine measurement in different clinical subgroups

Journal of Neurology ◽

10.1007/bf00886876 ◽

1996 ◽

Vol 243 (7) ◽

pp. 536-542 ◽

Cited By ~ 25

Author(s):

Marco Rovaris ◽

David Barnes ◽

Nicola Woodrofe ◽

George H. du Boulay ◽

John W. Thorpe ◽

...

Keyword(s):

Multiple Sclerosis ◽

Disease Activity ◽

Brain Mri ◽

Multiple Sclerosis Patients ◽

Cytokine Measurement

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Distinct patterns of active and non-active plaques using texture analysis on brain NMR images in multiple sclerosis patients: preliminary results

Magnetic Resonance Imaging ◽

10.1016/s0730-725x(99)00062-4 ◽

1999 ◽

Vol 17 (9) ◽

pp. 1261-1267 ◽

Cited By ~ 45

Author(s):

O Yu ◽

Y Mauss ◽

G Zollner ◽

I.J Namer ◽

J Chambron

Keyword(s):

Multiple Sclerosis ◽

Texture Analysis ◽

Preliminary Results ◽

Multiple Sclerosis Patients

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Signal abnormalities on 1.5 and 3 Tesla brain MRI in multiple sclerosis patients and healthy controls. A morphological and spatial quantitative comparison study

NeuroImage ◽

10.1016/j.neuroimage.2009.04.019 ◽

2009 ◽

Vol 47 (4) ◽

pp. 1352-1362 ◽

Cited By ~ 20

Author(s):

Carol Di Perri ◽

Michael G. Dwyer ◽

David S. Wack ◽

Jennifer L. Cox ◽

Komal Hashmi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Brain Mri ◽

Quantitative Comparison ◽

3 Tesla ◽

Healthy Controls ◽

Comparison Study ◽

Multiple Sclerosis Patients

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Assessment of the genetic contribution to brain MRI lesion load and atrophy measures in multiple sclerosis patients

European Journal of Neurology ◽

10.1111/ene.14872 ◽

2021 ◽

Author(s):

Ferdinando Clarelli ◽

Maria Assunta Rocca ◽

Silvia Santoro ◽

Ermelinda De Meo ◽

Laura Ferrè ◽

...

Keyword(s):

Multiple Sclerosis ◽

Brain Mri ◽

Genetic Contribution ◽

Lesion Load ◽

Multiple Sclerosis Patients

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A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands

Multiple Sclerosis Journal ◽

10.1191/1352458502ms831oa ◽

2002 ◽

Vol 8 (6) ◽

pp. 459-462 ◽

Cited By ~ 14

Author(s):

I Nakashima ◽

K Fujihara ◽

T Misu ◽

J Fujimori ◽

S Sato ◽

...

Keyword(s):

Multiple Sclerosis ◽

Brain Mri ◽

White Matter Lesions ◽

Diffuse White Matter ◽

Mri Features ◽

Spinal Form ◽

Magnetic Resonance Imaging Mri ◽

Oligoclonal Igg ◽

Multiple Sclerosis Patients ◽

Oligoclonal Igg Bands

The cerebrospinal fluid oligoclonal IgG bands (OB) are less frequently observed in Japanese multiple sclerosis (MS) patients compared with Caucasian patients. We studied 40 consecutive Japanese MS patients to investigate the differences in the clinical and magnetic resonance imaging (MRI) features of MS between OB-positive patients and OB-negative ones. Among the 40 patients, 22 (55%) patients were OB-positive by either agarose gel electrophoresis (AGE) or isoelectric focusing (IEF), and 18 (45%) patients were OB-negative by both AGE and IEF. There were differences between the two groups only in the clinical forms of MS, but not in terms of gender, onset age, disease duration, or disease severity. In the OB-negative group, nine (50%) of the patients had the optic-spinal form of MS (OS-MS), but only one patient (4.5%) in the OB-positive group had OS-MS. Although most OB-positive patients showed brain MRI lesions typical of MS, 13 (72%) of the OB-negative patients showed no or few brain MRI lesions and the rest of the OB-negative patients showed atypical MS lesions, such as diffuse white matter lesions or large ring-enhanced lesions. Our results suggest that the majority of OB-negative Japanese MS patients show either no or few brain MRI lesions or atypical brain MRI lesions.

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Relationship between MRI lesion activity and response to IFN-β in relapsing–remitting multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1177/1352458507085555 ◽

2008 ◽

Vol 14 (4) ◽

pp. 479-484 ◽

Cited By ~ 83

Author(s):

J Río ◽

À Rovira ◽

M Tintoré ◽

E Huerga ◽

C Nos ◽

...

Keyword(s):

Multiple Sclerosis ◽

Brain Mri ◽

Brain Lesion ◽

Brain Magnetic Resonance Imaging ◽

Relapsing Remitting ◽

Remitting Multiple Sclerosis ◽

Brain Parenchymal ◽

Multiple Sclerosis Patients ◽

Mri Changes ◽

Relapsing Remitting Multiple Sclerosis

Objective Our objective in this study is to evaluate whether brain magnetic resonance imaging (MRI) performed at interferon-beta (IFN-β) onset and after 12 months allow us to identify relapsing–remitting multiple sclerosis (RRMS) patients with a disability increase in the first 2 years of therapy. Methods This is a prospective and longitudinal study of patients with RRMS treated with IFN-β. All patients included underwent brain MRI before the onset of therapy with IFN-β and 12 months after. MRI measures (T2, unenhanced T1-weighted and gadolinium-enhancing T1-weighted brain lesion load, brain parenchymal fraction) were undertaken at baseline and after 12 months. The number of active lesions (new or enlarging T2 plus gadolinium-enhancing brain lesions) was also assessed on the 12 months MRI scan. Expanded Disability Status Scale (EDSS) was scored every 3 months. We defined an increase in disability as an increase of at least 1 EDSS point confirmed and sustained during the first 2 years of therapy with IFN-β. Regression analysis was performed in order to identify MRI variables of response. Results We included 152 patients who were followed-up for at least 2 years. After 2 years of therapy, 24 patients (16%) had an increase in disability. The logistic regression model showed that active lesions in the scan performed at 12 months were the most important factor related with the increase of disability after 2 years of therapy (odds ratio 8.3, 95% confidence interval 3.1–21.9; p < 0.0001). Conclusions In RRMS patients treated with IFN-β the MRI changes occurring during the first year may have a prognostic value for identifying patients with a confirmed increase of disability after 2 years of therapy.

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