A comparative study of Japanese multiple sclerosis patients with and without oligoclonal IgG bands

2002 ◽  
Vol 8 (6) ◽  
pp. 459-462 ◽  
Author(s):  
I Nakashima ◽  
K Fujihara ◽  
T Misu ◽  
J Fujimori ◽  
S Sato ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Mri ◽  
White Matter Lesions ◽  
Diffuse White Matter ◽  
Mri Features ◽  
Spinal Form ◽  
Magnetic Resonance Imaging Mri ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

The cerebrospinal fluid oligoclonal IgG bands (OB) are less frequently observed in Japanese multiple sclerosis (MS) patients compared with Caucasian patients. We studied 40 consecutive Japanese MS patients to investigate the differences in the clinical and magnetic resonance imaging (MRI) features of MS between OB-positive patients and OB-negative ones. Among the 40 patients, 22 (55%) patients were OB-positive by either agarose gel electrophoresis (AGE) or isoelectric focusing (IEF), and 18 (45%) patients were OB-negative by both AGE and IEF. There were differences between the two groups only in the clinical forms of MS, but not in terms of gender, onset age, disease duration, or disease severity. In the OB-negative group, nine (50%) of the patients had the optic-spinal form of MS (OS-MS), but only one patient (4.5%) in the OB-positive group had OS-MS. Although most OB-positive patients showed brain MRI lesions typical of MS, 13 (72%) of the OB-negative patients showed no or few brain MRI lesions and the rest of the OB-negative patients showed atypical MS lesions, such as diffuse white matter lesions or large ring-enhanced lesions. Our results suggest that the majority of OB-negative Japanese MS patients show either no or few brain MRI lesions or atypical brain MRI lesions.

Silver staining of unconcentrated cerebrospinal fluid in agarose gel (Panagel) electrophoresis.

1984 ◽  
Vol 30 (5) ◽  
pp. 735-736 ◽  
Author(s):  
P D Mehta ◽  
S P Mehta ◽  
B A Patrick
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Silver Staining ◽  
Clinical Laboratory ◽  
Neurological Diseases ◽  
Agarose Gel ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Coomassie Brilliant ◽  
Oligoclonal Igg Bands

Abstract We subjected cerebrospinal fluid (CSF) from 20 patients with multiple sclerosis and 20 patients with other neurological diseases to agarose gel ( Panagel ) electrophoresis followed by staining with silver. Ten microliters of unconcentrated CSF from multiple sclerosis patients containing 0.4 to 0.8 microgram of immunoglobulin G was found to be optimum for detection of oligoclonal IgG bands, so identified by immunofixation. The band patterns for unconcentrated CSF stained with silver were almost identical to those for the same CSF concentrated 40-fold and stained with Coomassie Brilliant Blue. Silver staining thus enables the clinical laboratory to electrophorese unconcentrated CSF on commercially prepared ( Panagel ) plates.

scholarly journals Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Martin W. Hümmert ◽  
Ulrich Wurster ◽  
Lena Bönig ◽  
Philipp Schwenkenbecher ◽  
Kurt-Wolfram Sühs ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Tear Fluid ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

Comparison of multiple sclerosis patients with and without oligoclonal IgG bands in South China

2019 ◽  
Vol 66 ◽  
pp. 51-55 ◽  
Author(s):  
Tingting Lu ◽  
Lin Zhao ◽  
Xiaobo Sun ◽  
Cheryl Au ◽  
Yinong Huang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
South China ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

Oligoclonal IgG bands in Japanese multiple sclerosis patients

1999 ◽  
Vol 101 (2) ◽  
pp. 205-206 ◽  
Author(s):  
Ichiro Nakashima ◽  
Kazuo Fujihara ◽  
Yasuto Itoyama
Keyword(s):  
Multiple Sclerosis ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

CD24 Gene Allele Variation Is Not Associated with Oligoclonal IgG Bands and IgG Index of Multiple Sclerosis Patients

2012 ◽  
Vol 19 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Mohammad Saadatnia ◽  
Mohammad Reza Najafi ◽  
Faride Najafi ◽  
Vahid Davoudi ◽  
Kiandokht Keyhanian ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Igg Index ◽  
Oligoclonal Igg ◽  
Allele Variation ◽  
Multiple Sclerosis Patients ◽  
Oligoclonal Igg Bands

Brain Lesion Load and Anatomic Distribution in Patients With Juvenile Clinically Isolated Syndrome Predicts Rapidly Advanced to Multiple Sclerosis

2018 ◽  
Vol 33 (10) ◽  
pp. 633-638
Author(s):  
Shay Menascu ◽  
Carolina Legarda ◽  
Shmuel Miron ◽  
Anat Achiron
Keyword(s):  
Multiple Sclerosis ◽  
Brain Mri ◽  
Age At Onset ◽  
Brain Lesion ◽  
Disease Onset ◽  
Clinically Isolated Syndrome ◽  
Lesion Load ◽  
Magnetic Resonance Imaging Mri ◽  
One Year ◽  
Multiple Sclerosis Patients

The aim was to assess brain lesion load and anatomical distribution in patients with juvenile clinically isolated syndrome and define magnetic resonance imaging (MRI) variables associated with rapidly advancing to multiple sclerosis. Patients were followed for one year after disease onset. Patients who experienced a second relapse were defined as those who rapidly advanced to multiple sclerosis. In all, 46 juvenile patients with a clinical presentation suggestive of multiple sclerosis were evaluated; 21 with gadolinium-enhancing lesions on initial brain MRI were excluded as they had already fulfilled the diagnosis criteria for multiple sclerosis. A total of 25 patients, 10 males and 15 females (mean ± SE age at onset 15.6 ± 0.6 years), met the definition of clinically isolated syndrome. The presence of a corpus callosum lesion at onset significantly differentiated between sustained clinically isolated syndrome and patients who rapidly advanced to multiple sclerosis.

Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid are less likely to develop neutralizing antibodies against interferon beta

2010 ◽  
Vol 16 (7) ◽  
pp. 796-800 ◽  
Author(s):  
M. Lundkvist ◽  
E. Greiner ◽  
J. Hillert ◽  
A. Fogdell-Hahn
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Oligoclonal Bands ◽  
Distinct Subgroup ◽  
Oligoclonal Igg ◽  
Multiple Sclerosis Patients ◽  
Genetically Determined ◽  
Oligoclonal Igg Bands

Multiple sclerosis patients without cerebrospinal fluid oligoclonal IgG bands have been proposed to constitute an immunogenetically distinct subgroup of multiple sclerosis that may also differ in terms of prognosis. A proportion of patients with multiple sclerosis receiving IFNβ develop neutralizing antibodies, which interfere with treatment efficacy. Evidence suggests that the likelihood of developing neutralizing antibodies is partly genetically determined. Here, we hypothesized that absence of oligoclonal IgG bands reflects a property of B-cell responses in oligoclonal IgG band-negative patients characterized by a lessened propensity to develop neutralizing antibodies. We aimed to compare the development of neutralizing antibodies against IFNβ between oligoclonal IgG band-negative and oligoclonal IgG band-positive multiple sclerosis patients. Treatment, oligoclonal IgG band and neutralizing antibody information was obtained for 2219 patients from the Swedish multiple sclerosis registry and the Swedish neutralizing antibody registry. Additional data on genotype was available for 532 patients. A correlation was found between oligoclonal IgG band negativity and neutralizing antibody negativity ( p = 0.02). This difference was confined to neutralizing antibodies against IFNβ-1a, since oligoclonal IgG band-negative patients were, to a lesser extent, neutralizing antibody positive compared with oligoclonal IgG band-positive patients if treated with IFNβ-1a (12% vs. 23%; p = 0.005). No difference was observed for IFNβ-1b-treated patients (44% vs. 46%). We propose that oligoclonal IgG band-negative patients differ immunologically from oligoclonal IgG band-positive patients, potentially influenced by distinct HLA-DRB1 alleles.

scholarly journals Assessment of Disability Progression Independent of Relapse and Brain MRI Activity in Patients with Multiple Sclerosis in Poland

2021 ◽  
Vol 10 (4) ◽  
pp. 868
Author(s):  
Katarzyna Kapica-Topczewska ◽  
François Collin ◽  
Joanna Tarasiuk ◽  
Agata Czarnowska ◽  
Monika Chorąży ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Activity ◽  
Brain Mri ◽  
Disability Progression ◽  
Program Monitoring ◽  
Therapeutic Program ◽  
Relapsing Remitting ◽  
Second Year ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

The aim of the study was to verify the association of clinical relapses and brain activity with disability progression in relapsing/remitting multiple sclerosis patients receiving disease-modifying treatments in Poland. Disability progression was defined as relapse-associated worsening (RAW), progression independent of relapse activity (PIRA), and progression independent of relapses and brain MRI Activity (PIRMA). Data from the Therapeutic Program Monitoring System were analyzed. Three panels of patients were identified: R0, no relapse during treatment, and R1 and R2 with the occurrence of relapse during the first and the second year of treatment, respectively. In the R0 panel, we detected 4.6% PIRA patients at 24 months (p < 0.001, 5.0% at 36 months, 5.6% at 48 months, 6.1% at 60 months). When restricting this panel to patients without brain MRI activity, we detected 3.0% PIRMA patients at 12 months, 4.5% at 24 months, and varying from 5.3% to 6.2% between 36 and 60 months of treatment, respectively. In the R1 panel, RAW was detected in 15.6% patients at 12 months and, in the absence of further relapses, 9.7% at 24 months and 6.8% at 36 months of treatment. The R2 group was associated with RAW significantly more frequently at 24 months compared to the R1 at 12 months (20.7%; p < 0.05), but without a statistical difference later on. In our work, we confirmed that disability progression was independent of relapses and brain MRI activity.

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