Love bite: An unusual differential diagnosis of an adverse reaction following the application of a gadolinium-based contrast agent

2022 ◽  
Author(s):  
Ingrid B. Boehm ◽  
Bert-Ram Sah
Keyword(s):  
Adverse Reaction ◽  
Differential Diagnosis ◽  
Contrast Agent

Preparation of Magnetic Resonance Nano Contrast Agent and Its Adoption in Diagnosis of Breast Cancer

2021 ◽  
Vol 13 (9) ◽  
pp. 1611-1621
Author(s):  
Rong Guo ◽  
Binbin Ma ◽  
Jiaqiu Nie
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Malignant Tumors ◽  
Nipple Discharge ◽  
Mri Contrast Agent ◽  
Cytotoxicity Test ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

This study aimed to explore the value of preoperative mammography in the differential diagnosis of benign and malignant tumors of nipple discharge. A biocompatible T1 contrast agent KMnF3 nanoparticle was first developed in the research, and then RGD-coupled KMnF3 nanoparticles were further synthesized as a highly sensitive tumor-targeted magnetic resonance imaging (MRI) contrast agent. While the nanoparticle was characterized physically, cytotoxicity test and MRI test in breast cancer mice were performed, and the excised tumors were subjected to immunostaining and tumor electron microscope section processing. At the same time, 60 patients with nipple discharge were screened to participate in the research, and the prepared MRI nano contrast agent was used for the differential diagnosis of breast benign/malignant tumors of nipple discharge. In the experiment, the synthetic nanoparticles were tested by Fourier transformed infrared (FTIR), which proved that the designed RGDtu/KMnF3 nanoparticles were successfully synthesized. The quantitative analysis of the synthesized nanoparticles showed that the relaxation efficiency reached 23.12 mM−1s−1, and there was no obvious toxicity. After staining, the microscope showed that the tumor was proliferating. After intravenous injection of low-dose RGDtu/KMnF3 contrast agent, nanoparticles were found in the tumor tissue. It was found that the synthesized nanoparticles enhanced the contrast of tumors with a volume of less than 50 mm3 by observing tumor slices. The imaging of the patient’s breast showed that the X-ray classification of galactography based on this contrast agent was statistically significant in distinguishing benign/malignant lesions of nipple discharge (X2 = 58.700, P < 0.01).

A case of adverse reaction potentially related to a microbubble contrast agent for ultrasonography

2004 ◽  
Vol 52 (1) ◽  
pp. 25-26 ◽  
Author(s):  
Nicola Crucinio ◽  
Maurizio Cosimo Nacchiero ◽  
Carmine Panella ◽  
Enzo Ierardi
Keyword(s):  
Adverse Reaction ◽  
Contrast Agent ◽  
Microbubble Contrast Agent

scholarly journals The Error of Differential Diagnosis of Pancreatic Cystic Lesion Using CEUS (Case Report)

2017 ◽  
pp. 29-35
Author(s):  
N. N. Askerova ◽  
A. N. Askerova ◽  
Yu. A. Stepanova ◽  
N. N. Vetsheva ◽  
A. V. Glotov
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Contrast Agent ◽  
Morphological Study ◽  
Cystic Lesion ◽  
Clinical Case ◽  
Cystic Tumor ◽  
Epithelial Lining ◽  
Retention Cyst ◽  
Co Morbidity

The use of the contrast agent SonoVue has been allowed in Russia since June 2014. Since then, russian experts have been accumulating their own experience in the contrast agent application for various diseases. The analysis of the obtained data showed that, besides the typical characteristics of the lesions enhancement, described in the literature, there can be atypical cases due to various causes (longterm course of the disease, co-morbidity). We present a clinical case of pancreas cystic lesion in female patient, that was misunderstood as a cystic tumor preoperatively. Considering the epithelial lining nature, absence of the accurate signs of the presence of an ovarian-like stroma, and also the significant secondary changes in the cystic wall such as hyalinosis, cholesterol deposits and macrophage accumulations, the lesion was interpreted as a long-standing pancreatic retention cyst with secondary changes by a morphological study. The features of the enhancement patterns of this lesion can be explained by the presence of significant secondary changes in the wall of cyst, that was first diagnosed in this patient 10 years ago.

Gadopentetate dimeglumine as a contrast agent in peripheral angioplasty

1998 ◽  
Vol 39 (5) ◽  
pp. 576-578 ◽  
Author(s):  
J. M. Murphy ◽  
N. J. O'hare ◽  
P. Smiddy ◽  
M. P. Molloy
Keyword(s):  
Adverse Reaction ◽  
Side Effects ◽  
Mr Imaging ◽  
Contrast Media ◽  
Contrast Agent ◽  
Gadopentetate Dimeglumine ◽  
Iodinated Contrast Media ◽  
Peripheral Angioplasty ◽  
Iodinated Contrast Medium ◽  
Iodinated Contrast

Gadopentetate dimeglumine (Gd-DTPA) is widely used as a contrast agent in MR imaging. We report on a case in which Gd-DTPA was used as the contrast agent during angioplasty in a patient who had recently had an adverse reaction to a non-ionic iodinated contrast medium. Gd-DTPA allowed a diagnostic angiogram to be performed with no side effects, and may thus be a useful contrast agent at angioplasty in patients with contra-indications to iodinated contrast media

scholarly journals A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Pinky Jha ◽  
Jeremiah Stromich ◽  
Mallory Cohen ◽  
Jane Njeri Wainaina
Keyword(s):  
Adverse Reaction ◽  
Differential Diagnosis ◽  
Clinical Practice ◽  
Early Diagnosis ◽  
Clinical Improvement ◽  
Aseptic Meningitis ◽  
Rare Complication ◽  
Signs And Symptoms ◽  
Drug Induced ◽  
Inflammatory Drugs

Drug induced aseptic meningitis is a rare but challenging diagnosis, most commonly reported with nonsteroidal anti-inflammatory drugs and antibiotics. Trimethoprim/sulfamethoxazole is a sulfonamide that is widely used in clinical practice for the treatment and prophylaxis of various infections. Drug induced aseptic meningitis, when seen with trimethoprim/sulfamethoxazole, occurs predominantly in patients with some degree of immune compromise and is less commonly seen in immune competent individuals. The patient often exhibits the classic symptoms of meningitis. Early diagnosis is important, since the cessation of the antibiotic leads to rapid clinical improvement. Trimethoprim/sulfamethoxazole induced aseptic meningitis has been underreported to FDA/MED-WATCH program. Here we report two cases of trimethoprim/sulfamethoxazole: an immune competent individual and immune compromised individual, both of which presented with signs of meningitis and a negative infectious workup. Trimethoprim/sulfamethoxazole is an uncommon and mysterious adverse reaction to a commonly used antibiotic. It should be considered in the differential diagnosis of patients presenting with acute signs and symptoms of meningitis especially after infectious causes have been ruled out.

An unusual adverse reaction to iodine-based contrast agent

2016 ◽  
Vol 32 ◽  
pp. e5-e6 ◽  
Author(s):  
Mirta Menegatti ◽  
Mario Pirisi ◽  
Mattia Bellan
Keyword(s):  
Adverse Reaction ◽  
Contrast Agent

scholarly journals Magnetic resonance colonography with intestine-absorbable nanoparticle contrast agents in evaluation of colorectal inflammation

2021 ◽  
Author(s):  
Xue Dong ◽  
Jingfeng Luo ◽  
Pengxun Lan ◽  
Xiuyu Guo ◽  
Xin Zhao ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Intravenous Injection ◽  
Fluorescein Isothiocyanate ◽  
Intestinal Wall ◽  
Enhancement Effect ◽  
Mri Findings ◽  
Significant Difference ◽  
Histological Confirmation

Abstract Objectives To develop a nanoparticle-based MRI protocol based on transrectal administration of intestine-absorbable nanoparticle contrast agents to evaluate ulcerative colitis (UC). Methods Solid lipid nanoparticles (SLNs) were synthesized by loading gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) and octadecylamine-fluorescein isothiocyanate to produce Gd-FITC-SLNs as T1 contrast agents. Twenty mice with acute UC were divided into four groups: enema with Gd-FITC-SLNs, intravenous injection of Gd-FITC-SLNs, enema with Gd-DTPA, and intravenous injection of Gd-DTPA. Five mice with chronic UC and five mice without UC underwent enema with Gd-FITC-SLNs. Axial T1- and T2-weighted MR images were obtained before and 20, 40, 60, 80,100, and 120 min after enema or intravenous injection of the contrast agent. The signal-to-noise ratios (SNRs) of the colorectal wall were measured in both groups. The MRI findings were correlated with subsequent histological confirmation. Results At 20 min after enema with Gd-FITC-SLNs, MRI showed the following contrast enhancement pattern: acute UC > normal intestinal wall > chronic UC. A continuous enhancement effect was observed in mice with acute UC, whereas a slight continuous enhancement of the colorectal wall was observed in mice with chronic UC. The normal intestinal wall rapidly metabolized the contrast agent, and the enhancement decreased on sequential scans. There was no significant difference between the SNRs of the intestinal wall at 20 min after intravenous Gd-DTPA and transrectal Gd-FITC-SLN administration. Conclusions Enema with Gd-FITC-SLNs may be helpful for the diagnosis and differential diagnosis of acute and chronic UC and can confer the same or better results than with intravenous Gd-DTPA. Key Points • Enema with Gd-FITC-SLNs may be helpful for the diagnosis and differential diagnosis of acute and chronic UC. • Enema with Gd-FITC-SLNs can achieve the same or better result than that with intravenous Gd-DTPA. • SLN-based MR colonography enhances the colorectal wall inflammation, based on the colonic absorption of the nanoparticle contrast agents.

scholarly journals CONTRAST-ENCHANCED ULTRASOUND IN THE DIFFERENTIAL DIAGNOSIS OF FOCAL NODULAR HYPERPLASIA AND HEPATIC ADENOMA

2019 ◽  
Vol 26 (2) ◽  
pp. 50-63 ◽  
Author(s):  
Alexey N. Katrich ◽  
Nikolai S. Ryabinin ◽  
Sergey V. Polshikov ◽  
Nikita A. Katrich
Keyword(s):  
Differential Diagnosis ◽  
Contrast Agent ◽  
Focal Nodular Hyperplasia ◽  
Ultrasound Contrast Agent ◽  
Hepatocellular Adenoma ◽  
Morphological Data ◽  
Arterial Phase ◽  
Benign Tumors ◽  
Focal Lesions ◽  
Nodular Hyperplasia

Aim. To increase the effectiveness of the differential diagnosis of benign focal lesions of the liver using contrast-enhanced ultrasound (CEUS).Materials and methods. A retrospective analysis of the examination results of 37 patients with morphologically confi rmed liver benign tumors was carried out. According to the morphological data, the patients were divided into two groups: 22 patients with focal nodular hyperplasia (FNH) and 15 patients with hepatocellular adenoma (HCA). All the patients underwent multiparametric ultrasound examination using CEUS.Results. According to the obtained data, despite the nearly equal intensity of fi lling FNH and HCA with a contrast agent (96% and 80%, accordingly), FNH is characterized by an earlier contrasting (WASH IN) pattern in the arterial phase (AF), with the ‘onset of contrasting in the focus’ parameter being signifi cantly different from HCA (p<0.05). Specifi c signs of FNH included the following: the spoke-wheel pattern and an increased intensity of ultrasound contrast agent (USCA) accumulation — 96% of cases; ‘center-to-edge’ fi lling — 86% of cases. WASH-OUT is not a typical sign of FNA. A complete (100% of cases) and intensive (80% of cases) centripetal (80% of cases) fi lling is characteristic of HCA. No specifi c types of vascular pattern were observed. In 6 (40%) patients, WASH-OUT and ‘relative hyperechoic’ were detected in the portal phase.Conclusion. CEUS is established to be an effective method of the differential diagnosis of FNH and HCA. 

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