Tired of not knowing what that fatigue score means? Normative data of the Modified Fatigue Impact Scale (MFIS)

Objective To assess the characteristics of the 6-min walk (6MW) in multiple sclerosis (MS) subjects of varied disability, and controls. To assess the correlation of 6MW to subjective measures of fatigue, health status and ambulation using the modified fatigue impact scale (MFIS), short form-36 Health Questionnaire physical component score and MS walking scale (MSWS). Methods Forty MS expanded disability status scale [(EDSS) 0—6.5] and 20 control subjects were recruited from a MS outpatient clinic. Subjects completed survey material and three 6MWs with 1-h interval rest in a single study visit. Results There was no practice effect or fatigability with repeat 6MW tests with a one-h rest period between test sessions. The 6MW had excellent intra-[intraclass correlation coefficient (ICC) = 0.95] and inter-rater (ICC = 0.91) reliability. MS subjects demonstrated reduced 6MW distance and speed compared with controls ( P < 0.0001). Within the MS population 6MW distance was significantly reduced with increasing disability ( P = 0.05). Compared with the EDSS, the 6MW had a stronger correlation to subjective measures of ambulation and physical fatigue: MSWS ( r = -0.81 versus 0.69) and MFISphy (0.66 versus 0.63). Conclusions The 6MW is a feasible, reproducible, and reliable measure in MS. MS subjects demonstrate motor fatigue in both 6MW distance and speed compared with controls. In MS subjects there is an inverse relationship between motor fatigue and disability. 6MW has a strong correlation to subjective measures of ambulation and physical fatigue. Multiple Sclerosis 2008; 14: 383—390. http://msj.sagepub.com

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Assessing fatigue in multiple sclerosis: Psychometric properties of the five-item Modified Fatigue Impact Scale (MFIS-5)

Multiple Sclerosis Journal - Experimental Translational and Clinical ◽

10.1177/2055217319887987 ◽

2019 ◽

Vol 5 (4) ◽

pp. 205521731988798 ◽

Cited By ~ 2

Author(s):

Virginia Meca-Lallana ◽

María Brañas-Pampillón ◽

Yolanda Higueras ◽

Antonio Candeliere-Merlicco ◽

Yolanda Aladro-Benito ◽

...

Keyword(s):

Multiple Sclerosis ◽

Psychometric Properties ◽

Impact Scale ◽

Fatigue Impact Scale

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Commentary on the paper “Reliability and validity of the Swedish version of the Fatigue Impact Scale (FIS)”

Scandinavian Journal of Occupational Therapy ◽

10.1080/11038120600691124 ◽

2006 ◽

Vol 13 (2) ◽

pp. 133-134

Author(s):

Ingvild Kjeken ◽

Hanne Dagfinrud

Keyword(s):

Reliability And Validity ◽

Swedish Version ◽

Impact Scale ◽

Fatigue Impact Scale

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Changes to the septo-fornical area might play a role in the pathogenesis of anxiety in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458517711273 ◽

2017 ◽

Vol 24 (8) ◽

pp. 1105-1114 ◽

Cited By ~ 7

Author(s):

Miklos Palotai ◽

Andrea Mike ◽

Michele Cavallari ◽

Erzsebet Strammer ◽

Gergely Orsi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Anxiety And Depression ◽

Ultra High Field ◽

Lesion Load ◽

Impact Scale ◽

Weighted Magnetic Resonance Imaging ◽

Fatigue Impact Scale ◽

Magnetic Resonance Imaging Mri ◽

Post Hoc ◽

Larger Sample

Background: Reports on the relationships between white matter lesion load (WMLL) and fatigue and anxiety in multiple sclerosis (MS) are inconsistent. Objective: To investigate the association of total and tract-specific WMLL with fatigue and anxiety. Methods: Total and regional T2 WMLL was assessed for 19 tracts in 48 MS patients (30 females). ICBM-DTI-81 Atlas-based parcellation was combined with WMLL segmentation of T2-weighted magnetic resonance imaging (MRI). Fatigue, anxiety, and depression were assessed using Fatigue Impact Scale, State Trait Anxiety Inventory, and Beck Depression Inventory, respectively. Results: Fatigue, anxiety, and depression showed significant inter-correlation. We found no association between fatigue and total or regional WMLLs, whereas anxiety was associated with total and regional WMLLs in nine tracts. After adjusting for total WMLL, age, and depression, only the column and body of the fornix (CBF) remained significantly associated with anxiety. Post hoc analyses showed no CBF lesions on T1-weighted MRI and suggested, but could not confirm, that the septum pellucidum might play a role in the pathogenesis of anxiety. Conclusion: Our results suggest that anxiety in MS patients may have a neuropathological substrate in the septo-fornical area, which requires further validation using larger sample size and ultra-high-field MRI in targeted prospective studies.

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A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site

Multiple Sclerosis Journal ◽

10.1177/1352458518775920 ◽

2018 ◽

Vol 25 (6) ◽

pp. 871-875 ◽

Cited By ~ 2

Author(s):

Cinda L Hugos ◽

Michelle H Cameron ◽

Zunqiu Chen ◽

Yiyi Chen ◽

Dennis Bourdette

Keyword(s):

Controlled Trial ◽

Control Program ◽

Group Program ◽

Delayed Effect ◽

Randomized Controlled ◽

Impact Scale ◽

Multicenter Randomized Controlled Trial ◽

Fatigue Impact Scale

Background: A four-site RCT of Fatigue: Take Control (FTC), a multicomponent group program, found no significant differences from a control program, MS: Take Control (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months. Objective: Assess FTC for a delayed effect on fatigue. Methods: Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months. Results: Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC −8.9 (confidence interval (CI): 32.2, 45), MSTC −2.5 (CI 39.6, 47.7), p = 0.03) at 12 months. Conclusion: The delayed effect of FTC on fatigue suggests the need for longer follow-up when assessing interventions for fatigue.

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Modified Fatigue Impact Scale--Persian Version

PsycTESTS Dataset ◽

10.1037/t62774-000 ◽

2013 ◽

Author(s):

Mahsa Ghajarzadeh ◽

Rozita Jalilian ◽

Ghazaleh Eskandari ◽

Mohammad Ali Sahraian ◽

Amir Reza Azimi

Keyword(s):

Persian Version ◽

Impact Scale ◽

Fatigue Impact Scale

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Psychometric properties of an Arabic translation of the modified fatigue impact scale in patients with multiple sclerosis

Disability and Rehabilitation ◽

10.1080/09638288.2020.1731853 ◽

2020 ◽

pp. 1-9

Author(s):

Abeer S. Alawami ◽

Fuad A. Abdulla

Keyword(s):

Multiple Sclerosis ◽

Psychometric Properties ◽

Arabic Translation ◽

Impact Scale ◽

Fatigue Impact Scale

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Comparing Individualized Rehabilitation to a Group Wellness Intervention for Persons with Multiple Sclerosis

American Journal of Health Promotion ◽

10.4278/ajhp.071211128 ◽

2009 ◽

Vol 24 (1) ◽

pp. 23-26 ◽

Cited By ~ 38

Author(s):

Matthew A. Plow ◽

Virgil Mathiowetz ◽

Dawn A. Lowe

Keyword(s):

Mental Health ◽

Multiple Sclerosis ◽

Physical Health ◽

Preliminary Evidence ◽

Effect Sizes ◽

Future Research ◽

Impact Scale ◽

Sf 36 ◽

Fatigue Impact Scale ◽

Wellness Intervention

Purpose. Compare the efficacy of two interventions designed to promote health and physical activity (PA). Design. This study was a randomized clinical trial using a time series design. Subjects were randomized into individualized physical rehabilitation (IPR) and group wellness intervention (GWI). Primary questionnaires were administered twice preintervention and twice postintervention. Physical fitness and PA frequency were assessed preintervention and postintervention. Setting. Clinic based in a metropolitan area. Subjects. Fifty volunteers with multiple sclerosis. Interventions. IPR consisted of four physical therapy sessions plus three telephone calls. GWI consisted of seven educational sessions. Measures. Primary: SF-36 Health Survey, Modified Fatigue Impact Scale, Mental Health Inventory. Secondary: physical assessment, PA frequency. Analysis. Stability of primary questionnaires between the two pretests was examined. Efficacy of interventions was evaluated by multivariate analysis of variance (MANOVA) and effect sizes. Results. Primary measures were stable between pretests. MANOVA showed nonsignificant differences between interventions. Eight weeks postintervention, both groups had improved PA, fatigue, resting heart rate, and strength. Effect sizes suggested that IPR had a greater effect on preventing decline of physical health, whereas GWI had a greater effect on improving mental health. Conclusion. Preliminary evidence indicated that health and PA improved in both groups. Effect sizes suggested that participants benefited more physically from IPR and more mentally from GWI. Future research should determine whether combining therapeutic exercise with group education improves both mental and physical health.

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