Biomimetic synthesis of hollow calcium carbonate with the existence of the agar matrix and bovine serum albumin

2016 ◽  
Vol 58 ◽  
pp. 409-411 ◽  
Author(s):  
Jianhua Feng ◽  
Gang Wu ◽  
Chengsong Qing
Keyword(s):  
Calcium Carbonate ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Biomimetic Synthesis

Bovine Serum Albumin-Directed Fabrication of Nanohydroxyapatite with Improved Stability and Biocompatibility

2021 ◽  
pp. 2150028
Author(s):  
Ting Li ◽  
Jialu Yu ◽  
Hao Sui ◽  
Tao Zhang ◽  
Ronghui Zhou
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Bone Repair ◽  
Practical Importance ◽  
Biomimetic Synthesis ◽  
Biological Macromolecules ◽  
Reaction Conditions ◽  
Physical Conditions ◽  
Improved Stability

Nanohydroxyapatite (nHAp) has gained considerable concerns due to its vast potential in biomedical applications such as drug delivery, tissue engineering and bone repair. However, the preparation of HAp nanostructures in a controllable manner under environment-friendly reaction conditions remains a challenge. In recent years, the use of biological macromolecules or proteins as templates in the production of nanomaterials has gained more attention due to the relatively mild physical conditions needed for biomimetic synthesis. In this study, a novel nHAp was fabricated by employing bovine serum albumin (BSA) as template under mild condition. After that, the as-obtained nanostructured materials which have well-defined structures and morphologies were characterized by various methods. Furthermore, the rod-like shaped hydroxyapatite demonstrated improved stability properties, as well as cell viability and biocompatibility, compared to BSA free synthesized c-HAp. We expect that this pleasantly novel research will render new insights into the fabrication strategies of nanomaterials and be of practical importance for the expanding biological application.

scholarly journals Experimental Study on MICP Aqueous Solution under the Action of Different Organic Substrates

Geofluids ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Huai-miao Zheng ◽  
Ling-ling Wu ◽  
Kai-wen Tong ◽  
Lin Hu ◽  
Qing Yu ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Mass Fraction ◽  
Organic Matrix ◽  
Egg White ◽  
Control Group ◽  
Organic Substrates ◽  
Carbonate Formation

The precipitation rate and cementation strength of calcium carbonate crystals during the process of microorganism-induced calcium carbonate precipitation (MICP) are key factors that affect the application effect of this technology. In order to improve the quality of calcium carbonate formation in the MICP process, egg white protein with a volume fraction of 20%, bovine serum albumin with a mass fraction of 0.3%, sucrose with a mass fraction of 5%, bamboo leaves with a mass concentration of 25 g/L, and bamboo leaf-magnesium chloride (Mg2+/Ca2+=4:1) were added during the experiment of different groups of MICP solutions. The results of the solution test study showed that there was no obvious lag period for bacterial growth under the action of organic matrix. The concentration of bacteria in the reaction solution was higher under the action of sucrose and egg white. The conversion rate of Ca2+ under the action of egg white was the fastest, which was about 2.5 times higher than that of the control group. After 14 days of grouting reaction, it was found that the proportion of calcite-type calcium carbonate produced under the action of egg white was the highest, and the Ca element accounted for 66.24% in the solidified material. Sucrose was second; bovine serum albumin was the lowest. The calcium carbonate crystals generated by the control of each organic matrix had a high degree of pore size matching with the tailings under a dry-wet cycle. The structural characteristics of the calcium carbonate crystals, such as crystal form, morphology, and particle size, were mainly due to the interaction between the organic matrix and the calcium carbonate crystals. This study proves that the addition of the organic matrix can improve the formation rate and crystal structure of calcium carbonate during MICP, thus providing a new reference for the development of MICP technology.

Biomimetic synthesis of HgS nanoparticles in the bovine serum albumin solution

2007 ◽  
Vol 10 (4) ◽  
pp. 559-566 ◽  
Author(s):  
De Zhi Qin ◽  
Xiao Ming Ma ◽  
Lin Yang ◽  
Li Zhang ◽  
Zhong Jun Ma ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Biomimetic Synthesis ◽  
Bovine Serum Albumin Solution ◽  
Albumin Solution

Bovine Serum Albumin as a Versatile Platform for Cancer Imaging and Therapy

2018 ◽  
Vol 25 (25) ◽  
pp. 2938-2953 ◽  
Author(s):  
Jun Wang ◽  
Bingbo Zhang
Keyword(s):  
Surface Modification ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Cancer Imaging ◽  
Drug Carrier ◽  
Drug Loading ◽  
Biomimetic Synthesis ◽  
Life Extension

Background: Due to the good biocompatibility, biodegradability, facile surface functionalization and high water solubility, Bovine serum albumin has gain increasing attention in the nanomedicine. Objective: Despite there are many reviews on albumin based nanoparticles, most of them focus on one aspect of the albumin functionality, e.g., drug delivery, cancer theranostics or half-life extension in vivo. This review aims to comprehensively summary bovine serum albumin as a versatile platform in the applications of cancer imaging and therapy. Methods: We review the extensive applications of bovine serum albumin in drug carrier, surface engineering and biomimetic synthesis for cancer imaging and therapy. Conclusion: Based on the studies reviewed, variety of in vitro and in vivo studies show good performance of bovine serum albumin as the drug carrier, surface modification agent and biomimetic template in cancer imaging and therapy. Nevertheless, there are still some issues to be solved, e.g., the technological parameters for enhancing the drug loading efficiency and controlling drug release, optimizing surface modification process to provide more stable nanoagents, investigation of the biomimetic mechanism, in-depth study of their toxicity, further exploring their bioapplications, etc.

scholarly journals Sucrose/bovine serum albumin mediated biomimetic crystallization of calcium carbonate

2009 ◽  
Vol 121 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Cheng-Li Yao ◽  
Wang-Hua Xu ◽  
Ai-Min Ding ◽  
Jin-Mao Zhu
Keyword(s):  
Calcium Carbonate ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum
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