New tools to design smart thermosensitive hydrogels for protein rectal delivery in IBD

2020 ◽  
Vol 106 ◽  
pp. 110252 ◽  
Author(s):  
Lorena Garcia-del Rio ◽  
Patricia Diaz-Rodriguez ◽  
Mariana Landin
Keyword(s):  
Thermosensitive Hydrogels ◽  
Rectal Delivery

Recent Advances in Thermosensitive Hydrogels as Drug Delivery Systems: A Review

2011 ◽  
Vol 1 (2) ◽  
pp. 135-149
Author(s):  
Jose Maria Bermudez ◽  
Daniela Quinteros ◽  
Ricardo Grau ◽  
Daniel Allemandi ◽  
Santiago Palma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Thermosensitive Hydrogels

scholarly journals Injectable and thermosensitive hydrogels mediating a universal macromolecular contrast agent with radiopacity for noninvasive imaging of deep tissues

2021 ◽  
Vol 6 (12) ◽  
pp. 4717-4728
Author(s):  
Xiaohui Wu ◽  
Xin Wang ◽  
Xiaobin Chen ◽  
Xiaowei Yang ◽  
Qian Ma ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Noninvasive Imaging ◽  
Thermosensitive Hydrogels

Analyzing the Effects of Silica Nanospheres on the Sol–Gel Transition Profile of Thermosensitive Hydrogels

Langmuir ◽  
2021 ◽  
Author(s):  
Lucas S. Ribeiro ◽  
Renata L. Sala ◽  
Leticia A. O. de Jesus ◽  
Sandra A. Cruz ◽  
Emerson R. Camargo
Keyword(s):  
Sol Gel ◽  
Silica Nanospheres ◽  
Thermosensitive Hydrogels ◽  
Sol Gel Transition ◽  
Gel Transition ◽  
Transition Profile

Effect of aprotinin on the rectal delivery of insulin

1983 ◽  
Vol 35 (9) ◽  
pp. 616-617 ◽  
Author(s):  
Toshiaki Nishihata ◽  
Gary Liversidge ◽  
Takeru Higuchi
Keyword(s):  
Rectal Delivery

Photopolymerized Thermosensitive Hydrogels: Synthesis, Degradation, and Cytocompatibility

2008 ◽  
Vol 9 (3) ◽  
pp. 919-926 ◽  
Author(s):  
Tina Vermonden ◽  
Natalja E. Fedorovich ◽  
Daphne van Geemen ◽  
Jacqueline Alblas ◽  
Cornelus F. van Nostrum ◽  
...  
Keyword(s):  
Thermosensitive Hydrogels

Preparation and Characterization of Drug-Loaded Thermosensitive Hydrogels

2013 ◽  
Author(s):  
L. Saeednia ◽  
A. Usta ◽  
R. Asmatulu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Body Temperature ◽  
Network Formation ◽  
Gelation Time ◽  
The Body ◽  
Antibacterial Drug ◽  
Natural Polymers ◽  
3D Network ◽  
Thermosensitive Hydrogels

Hydrogels are the promising classes of polymeric drug delivery systems with the controlled release rates. Among them, injectable thermosensitive hydrogels with transition temperature around the body temperature have been wildly considered. Chitosan is one of the most abundant natural polymers, and its biocompatibility and biodegradability makes it a favorable thermosensitive hydrogel that has been attracted much attention in biomedical field worldwide. In this work, a thermosensitive and injectable hydrogel was prepared using chitosan and β-glycerophosphate (β-GP) incorporated with an antibacterial drug (gentamycin). This drug loaded hydrogel is liquid at room temperature, and becomes more solidified gel when heated to the body temperature. Adding β-GP into chitosan and drug molecules and heating the overall solution makes the whole homogenous liquid into gel through a 3D network formation. The gelation time was found to be a function of temperature and concentration of β-GP. This thermosensitive chitosan based hydrogel system was characterized using FTIR and visual observation to determine the chemical structure and morphology. The results confirmed that chitosan/(β-GP) hydrogels could be a promising controlled-release drug delivery system for many deadly diseases.

scholarly journals Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting.

2021 ◽  
Author(s):  
Malik Salman Haider ◽  
Taufiq Ahmad ◽  
Mengshi Yang ◽  
Chen Hu ◽  
Lukas Hahn ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Gel Strength ◽  
Adipose Derived Stem Cells ◽  
3D Bioprinting ◽  
Thermosensitive Hydrogel ◽  
Clay Nanoparticles ◽  
Hydrogel Matrix ◽  
Thermosensitive Hydrogels ◽  
3D Printed

As one kind of smart material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. Here, we reported on a novel thermosensitive hydrogel which can be 3D printed using extrusion based printing. Gel strength was found around 3kPa storage modulus with pronounced shear thinning and rapid recovery after stress. Addition of clay nanoparticles (Laponite XLG) improved the rheological profile further. Human adipose derived stem cells were added to the hydrogel matrix, which remained fully viable after printing. Therefore, the presented materials adds to the available material toolbox for 3D bioprinting. <br>

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