Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity

2020 ◽  
Vol 109 ◽  
pp. 110599 ◽  
Author(s):  
Jun Wu ◽  
Kyosuke Ueda ◽  
Takayuki Narushima
Keyword(s):  
Antibacterial Activity ◽  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Amorphous Calcium Phosphate ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films ◽  
Co Doped

Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

2009 ◽  
Vol 631-632 ◽  
pp. 211-216 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
T. Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

Calcium Phosphate Coating on Titanium Using Dry Process

2010 ◽  
Vol 654-656 ◽  
pp. 2162-2167
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Jun Kurihara ◽  
Hiroshi Kawamura
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films ◽  
Removal Torque

Oxyapatite, amorphous calcium phosphate, and double-layered calcium phosphate coating films were fabricated on mirror-polished commercially pure titanium (CP Ti) and blasted Ti-6Al-4V alloy substrates by radiofrequency (RF) magnetron sputtering; the properties of these films were evaluated in vivo and in vitro. The bonding strength between the calcium phosphate films and the Ti substrates was higher than 50 MPa. This value is higher than the bonding strength reported in the case of plasma-sprayed calcium phosphate coating films fabricated on Ti substrates. The removal torque of screw-type blasted Ti-6Al-4V alloy implants in the femurs of Japanese white rabbits increased with the duration of implantation, and the removal torque values of the coated implants was observed to be higher than those of the non-coated implants. In vitro and in vivo studies indicate that coating Ti implants with calcium phosphate films using RF magnetron sputtering is effective in improving the bone compatibility of Ti implants. Finally, the factors that should be considered in fabricating biomedical coating films were discussed.

scholarly journals Evaluation of Calcium Phosphate Coating Films on Titanium Fabricated Using RF Magnetron Sputtering

2007 ◽  
Vol 48 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Characterization of Calcium Phosphate Films Prepared by RF Magnetron Sputtering

2005 ◽  
Vol 888 ◽  
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Amorphous Calcium Phosphate ◽  
Pure Titanium ◽  
Active Surface ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Commercially Pure Titanium ◽  
Cp Ti

ABSTRACTCalcium phosphate films were prepared on commercially pure titanium (CP-Ti) substrates by RF magnetron sputtering using β-tricalcium phosphate targets. XRD and FTIR analyses showed that the films consisted of amorphous calcium phosphate and oxyapatite phases. The (002) preferred orientation of the oxyapatite phase was observed depending on the oxygen gas concentration in the sputtering gas. The surface reactions of the calcium phosphate films were investigated in Hanks' solution and PBS(-). Apatite crystallites were detected on the films after immersion for 7 days. An active surface reaction was observed on the amorphous calcium phosphate films during immersion in PBS(-). The CP-Ti plates coated with the calcium phosphate films were placed on the mandible of male Japanese white rabbits. These results suggest that the calcium phosphate coating improves the biocompatibility of titanium implants with bone.

Fabrication and Evaluation of Calcium Phosphate Coating Films on Blast-treated Ti-6Al-4V Alloy Substrate

2008 ◽  
Vol 55 (5) ◽  
pp. 318-324 ◽  
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda ◽  
Takashi Goto ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films ◽  
Alloy Substrate

Tissue culture on amorphous calcium phosphate coating

Bioceramics ◽  
1997 ◽  
pp. 253-256
Author(s):  
Kazuya Suzuki ◽  
Yoshihiko Kageyama ◽  
Yusuke Kita ◽  
Atsuto Yoshino ◽  
Kozo Matsushita ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating

Calcium Phosphate Coating on Titanium by RF Magnetron Sputtering

2012 ◽  
pp. 223-233
Author(s):  
Takayuki Narushima ◽  
Kyosuke Ueda
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Metallic Biomaterials ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

In this chapter, the authors discuss the fabrication and properties of calcium phosphate coatings on titanium (Ti) by radio-frequency (RF) magnetron sputtering. First, they address the necessity of surface modification of metallic biomaterials and the effectiveness of calcium phosphate coating. Next, they briefly review the processes used in the application of calcium phosphate coatings and present the effect of sputtering parameters on the phase and deposition rates of these coatings. Finally, the chapter discusses the performance of amorphous and crystalline (oxyapatite) calcium phosphate coatings on Ti based on in vitro and in vivo evaluations.

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