scholarly journals 3D printed silica-gelatin hybrid scaffolds of specific channel sizes promote collagen type II, Sox9 and Aggrecan production from chondrocytes

2021 ◽  
pp. 111964
Author(s):  
Maria Nelson ◽  
Siwei Li ◽  
Samuel J. Page ◽  
Xiaomeng Shi ◽  
Peter D. Lee ◽  
...  
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii ◽  
3D Printed ◽  
Hybrid Scaffolds

Specificity and T cell receptor β chain usage of a human collagen type II-reactive T cell clone derived from a healthy individual

1992 ◽  
Vol 22 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Tan Yan ◽  
Harald Burkhardt ◽  
Thomas Ritter ◽  
Barbara Bröker ◽  
Karl Heinz Mann ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Collagen Type ◽  
Cell Clone ◽  
Cell Receptor ◽  
Type Ii ◽  
Collagen Type Ii ◽  
T Cell Clone ◽  
Human Collagen ◽  
Β Chain

Localization of pro-collagen type ii mrna and collagen type ii in the healing tooth socket of the rat

1995 ◽  
Vol 40 (3) ◽  
pp. 181-185 ◽  
Author(s):  
H. Devlin ◽  
J. Hoyland ◽  
A.J. Freemont ◽  
P. Sloan
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Tooth Socket

Compressive compared with tensile loading of medial collateral ligament scarin vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase

2000 ◽  
Vol 18 (4) ◽  
pp. 524-531 ◽  
Author(s):  
Tokifumi Majima ◽  
Linda L. Marchuk ◽  
Paul Sciore ◽  
Nigel G. Shrive ◽  
Cyril B. Frank ◽  
...  
Keyword(s):  
Medial Collateral Ligament ◽  
Collagen Type ◽  
Tensile Loading ◽  
Mrna Levels ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Collateral Ligament

scholarly journals SAT0052 The coll2–1 peptide of collagen type ii: a new actor of synovitis in osteoarthritis

2018 ◽  
Author(s):  
C. Lambert ◽  
D. Borderie ◽  
F. Rannou ◽  
Y. Henrotin
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii

scholarly journals Role of undenatured collagen type ii in management of osteoarthritis: A hospital based study

2020 ◽  
Vol 6 (4) ◽  
pp. 747-750
Author(s):  
Dr. Sathik Babu ◽  
Dr. Pradeep Elangovan ◽  
Dr. Dinesh Kumar S
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii

scholarly journals The Coll2-1 peptide of collagen type II: a new actor of synovitis in osteoarthritis

2018 ◽  
Vol 26 ◽  
pp. S120-S121 ◽  
Author(s):  
C. Lambert ◽  
D. Borderie ◽  
F. Rannou ◽  
Y. Henrotin
Keyword(s):  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii

Phenotypic maintenance of articular chondrocytes in vitro requires BMP activity

2007 ◽  
Vol 20 (03) ◽  
pp. 185-191 ◽  
Author(s):  
A. O. Oshin ◽  
E. Caporali ◽  
C. R. Byron ◽  
A. A. Stewart ◽  
M. C. Stewart
Keyword(s):  
Articular Cartilage ◽  
Collagen Type ◽  
Articular Chondrocytes ◽  
Soluble Form ◽  
Mrna Levels ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Endogenous Expression ◽  
Chondrocytic Phenotype

SummaryArticular chondrocytes are phenotypically unique cells that are responsible for the maintenance of articular cartilage. The articular chondrocytic phenotype is influenced by a range of soluble factors. In particular, members of the bone morphogenetic protein (BMP) family support the articular chondrocytic phenotype and stimulate synthesis of cartilaginous matrix. This study was carried out to determine the importance of BMPs in supporting the differentiated phenotype of articular chondrocytes in vitro. Exogenous BMP-2 supported expression of collagen type II and aggrecan in monolayer chondrocyte cultures, slowing the dedifferentiation process that occurs under these conditions. In contrast, BMP-2 had little effect on expression of these genes in three-dimensional aggregate cultures. Endogenous BMP-2 expression was lost in monolayer cultures, coincident with the down-regulation of collagen type II and aggrecan mRNAs, whereas BMP-2 mRNA levels were stable in aggregate cultures. Antagonism of endogenous BMP activity in aggregate cultures by Noggin or a soluble form of the BMP receptor resulted in reduced expression of collagen type II and aggrecan mRNAs, reduced collagen type II protein and sulfated glycosaminoglycan (GAG) deposition into the aggregate matrices and reduced secretion of GAGs into the culture media. These results indicate that endogenous BMPs are required for maintenance of the differentiated articular chondrocytic phenotype in vitro. These findings are of importance to cell-based strategies designed to repair articular cartilage. Articular chondrocytes require conditions that will support endogenous expression of BMPs to maintain the specialized phenotype of these cells.

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