Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis

2010 ◽  
Vol 38 (2) ◽  
pp. 201-209 ◽  
Author(s):  
Anat Achiron ◽  
Itamar Grotto ◽  
Ran Balicer ◽  
David Magalashvili ◽  
Anna Feldman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nuclear Receptor ◽  
Microarray Analysis ◽  
Family Members ◽  
Disease State ◽  
Altered Regulation ◽  
Nuclear Receptor Family ◽  
Receptor Family

scholarly journals NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

Blood ◽  
2017 ◽  
Vol 130 (8) ◽  
pp. 1014-1025 ◽  
Author(s):  
Lynne R. Prince ◽  
Svenja D. Prosseda ◽  
Kathryn Higgins ◽  
Jennifer Carlring ◽  
Elizabeth C. Prestwich ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Family Members ◽  
Orphan Nuclear Receptor ◽  
Neutrophil Number ◽  
Key Points ◽  
Nuclear Receptor Family ◽  
Receptor Family

Key Points We demonstrate an important role for NR4A receptors in regulating neutrophil lifespan and homeostasis in vitro and in vivo. These findings may define targets for therapies for diseases driven by defects in neutrophil number and/or survival.

scholarly journals Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Laurent L’homme ◽  
Benan Pelin Sermikli ◽  
Olivier Molendi-Coste ◽  
Sébastien Fleury ◽  
Sandrine Quemener ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Nuclear Receptor ◽  
High Fat Diet ◽  
Cell Function ◽  
Retinoic Acid Receptor ◽  
Orphan Receptor ◽  
Nuclear Receptor Family ◽  
Receptor Family ◽  
Diet Model

AbstractRetinoic acid receptor-related orphan receptor-alpha (RORα) is a transcription factor from the nuclear receptor family expressed by immune cells and involved in the development of obesity, insulin resistance (IR) and non-alcoholic steatohepatitis (NASH). It was recently reported that mice deficient for RORα in macrophages develop more severe NASH upon high fat diet (HFD) feeding due to altered Kupffer cell function. To better understand the role of RORα in obesity and IR, we independently generated a macrophage RORα-deficient mouse line. We report that RORα deletion in macrophages does not impact on HFD-induced obesity and IR. Surprisingly, we did not confirm an effect on NASH development upon HFD feeding nor in the more severe and obesity-independent choline-deficient, L-amino acid-defined diet model. Our results therefore show that RORα deletion in macrophages does not alter the development of obesity and IR and question its role in NASH.

scholarly journals Expression and Function of Members of a Divergent Nuclear Receptor Family in Caenorhabditis elegans

1999 ◽  
Vol 215 (2) ◽  
pp. 314-331 ◽  
Author(s):  
Tomoyuki Miyabayashi ◽  
Mark T Palfreyman ◽  
Ann E Sluder ◽  
Frank Slack ◽  
Piali Sengupta
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Receptor ◽  
Nuclear Receptor Family ◽  
And Function ◽  
Receptor Family

Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family

1999 ◽  
Vol 155 (1-2) ◽  
pp. 51-60 ◽  
Author(s):  
Azriel Schmidt ◽  
Robert Vogel ◽  
M.Katharine Holloway ◽  
Su Jane Rutledge ◽  
Oren Friedman ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Nuclear Receptor ◽  
Transcription Control ◽  
Nuclear Receptor Family ◽  
Receptor Family
Sign in / Sign up

Export Citation Format

Share Document