Microinjection of prostaglandin E2 and muscimol into the preoptic area in conscious rats: Comparison of effects on plasma adrenocorticotrophic hormone (ACTH), body temperature, locomotor activity, and cardiovascular function

2006 ◽  
Vol 397 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Dmitry V. Zaretsky ◽  
Joseph L. Hunt ◽  
Maria V. Zaretskaia ◽  
Joseph A. DiMicco
Keyword(s):  
Locomotor Activity ◽  
Body Temperature ◽  
Prostaglandin E2 ◽  
Preoptic Area ◽  
Cardiovascular Function ◽  
Adrenocorticotrophic Hormone ◽  
Conscious Rats

scholarly journals Effects of buprenorphine on body temperature, locomotor activity and cardiovascular function when assessed by telemetric monitoring in rats

2008 ◽  
Vol 42 (2) ◽  
pp. 149-160 ◽  
Author(s):  
N-G Ilbäck ◽  
M Siller ◽  
T Stålhandske
Keyword(s):  
Locomotor Activity ◽  
Body Temperature ◽  
Cardiovascular Function

Effects of buprenorphine on body temperature, locomotor activity and cardiovascular function when assessed by telemetric monitoring in rats

2008 ◽  
Vol 42 (4) ◽  
pp. 516-516
Author(s):  
Naomi M Gades ◽  
Peggy J Danneman ◽  
Sally K Wixson ◽  
Elizabeth A Tolley
Keyword(s):  
Locomotor Activity ◽  
Body Temperature ◽  
Cardiovascular Function

Interaction between norepinephrine and prostaglandin E2 in the preoptic area of guinea pigs

1996 ◽  
Vol 271 (3) ◽  
pp. R528-R536 ◽  
Author(s):  
E. Sehic ◽  
A. L. Ungar ◽  
C. M. Blatteis
Keyword(s):  
Cerebrospinal Fluid ◽  
Body Temperature ◽  
Prostaglandin E2 ◽  
Intravenous Injection ◽  
Guinea Pigs ◽  
Preoptic Area ◽  
Extracellular Fluid ◽  
Low Ph ◽  
Febrile Response ◽  
Artificial Cerebrospinal Fluid

The release of norepinephrine (NE) and prostaglandin E2 (PGE2) in the preoptic-anterior hypothalamus (POA) by systemically administered pyrogens suggests that both substances may mediate the febrile response. To investigate their possible interaction, we measured directly the levels of PGE2 in the extracellular fluid of the POA of conscious guinea pigs microdialyzed intrapreoptically with exogenous NE over the entire course of their febrile response to endotoxin. Acidified and buffered NE (NEa, NEb), artificial cerebrospinal fluid (aCSFa, aCSFb), and vehicle (Veha, Vehb) were tested. All but aCSFb depressed the febrile response to endotoxin. The microdialysis of aCSFa, aCSFb, Veha, Vehb, and NEa did not change basal preoptic PGE2 levels. However, NEb, at a dose that by itself did not affect body temperature (Tb), caused a large elevation in preoptic PGE2. The intravenous injection of endotoxin increased the level of PGE2 in the POA. NEb potentiated this increase, whereas NEa, aCSFa, and Vehb reduced it; Veha reduced it for the first 60 min and enhanced it for the last 90 min of the experiment. Thus these data suggest that the low pH of the NE solute and/or its Veh may confound the observed effects of NE on the Tb and preoptic PGE2 induced by endotoxin. We surmise that this is due to a neurotoxic action of the antioxidants and the acidity of the solution on thermosensitive neurons in the POA. Hence, the results of experiments using exogenous, usually acidified, NE preparations that often also contain additives should be interpreted with caution.

Activation of sympathetic outflow by recombinant human interleukin-1 beta in conscious rats

1996 ◽  
Vol 270 (2) ◽  
pp. R479-R485 ◽  
Author(s):  
H. Kannan ◽  
Y. Tanaka ◽  
T. Kunitake ◽  
Y. Ueta ◽  
Y. Hayashida ◽  
...  
Keyword(s):  
Body Temperature ◽  
Prostaglandin E2 ◽  
Interleukin 1 ◽  
Plasma Norepinephrine ◽  
Intracerebroventricular Injection ◽  
Sympathetic Outflow ◽  
Interleukin 1 Beta ◽  
Conscious Rats ◽  
Arterial Blood ◽  
Intracerebroventricular Injections

The present study was undertaken to determine the effects of interleukin-1 beta (IL-1 beta) on renal sympathetic nerve activity (RSNA), arterial blood pressure (AP), heart rate (HR), and body temperature in conscious rats. Either intravenous or intracerebroventricular administration of IL-1 beta elicited increases in AP, HR, and RSNA accompanied by a rise in body temperature. The maximum changes in AP, HR, and RSNA occurred 10-15 min after intravenous injection of IL-1 beta (100 ng) and 20-25 min after intracerebroventricular injection (5 ng). The responses induced by the intravenous and intracerebroventricular injections lasted for approximately 15-30 min and did not appear when the animals were pretreated with the cyclooxygenase inhibitor indomethacin (10 mg/kg iv). Moreover, intracerebroventricular injection of prostaglandin E2 (1 microgram) produced responses similar to those induced by IL-1 but with shorter latency. Plasma norepinephrine and adrenocorticotropic hormone concentrations were increased after IL-1 beta injection. The results suggested that IL-1 beta augments cardiovascular and sympathetic outflow through the central action of prostaglandin E2 in conscious rats.

Light-induced suppression of the rat circadian system

1995 ◽  
Vol 268 (5) ◽  
pp. R1111-R1116 ◽  
Author(s):  
P. Depres-Brummer ◽  
F. Levi ◽  
G. Metzger ◽  
Y. Touitou
Keyword(s):  
Locomotor Activity ◽  
Body Temperature ◽  
Circadian Rhythms ◽  
Prolonged Exposure ◽  
Light Exposure ◽  
Continuous Light ◽  
Circadian System ◽  
Short Exposure ◽  
Complete Suppression ◽  
Continuous Darkness

In a constant environment, circadian rhythms persist with slightly altered period lengths. Results of studies with continuous light exposure are less clear, because of short exposure durations and single-variable monitoring. This study sought to characterize properties of the oscillator(s) controlling the rat's circadian system by monitoring both body temperature and locomotor activity. We observed that prolonged exposure of male Sprague-Dawley rats to continuous light (LL) systematically induced complete suppression of body temperature and locomotor activity circadian rhythms and their replacement by ultradian rhythms. This was preceded by a transient loss of coupling between both functions. Continuous darkness (DD) restored circadian synchronization of temperature and activity circadian rhythms within 1 wk. The absence of circadian rhythms in LL coincided with a mean sixfold decrease in plasma melatonin and a marked dampening but no abolition of its circadian rhythmicity. Restoration of temperature and activity circadian rhythms in DD was associated with normalization of melatonin rhythm. These results demonstrated a transient internal desynchronization of two simultaneously monitored functions in the rat and suggested the existence of two or more circadian oscillators. Such a hypothesis was further strengthened by the observation of a circadian rhythm in melatonin, despite complete suppression of body temperature and locomotor activity rhythms. This rat model should be useful for investigating the physiology of the circadian timing system as well as to identify agents and schedules having specific pharmacological actions on this system.

scholarly journals A versatile telemetry system for continuous measurement of heart rate, body temperature and locomotor activity in free-ranging ruminants

2010 ◽  
Vol 1 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Claudio Signer ◽  
Thomas Ruf ◽  
Franz Schober ◽  
Gerhard Fluch ◽  
Thomas Paumann ◽  
...  
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Continuous Measurement ◽  
Telemetry System ◽  
Free Ranging
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