Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome

2007 ◽  
Vol 423 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Christian Arriagada ◽  
César Astorga ◽  
Illani Atwater ◽  
Eduardo Rojas ◽  
David Mears ◽  
...  
Keyword(s):  
Animal Model ◽  
Down Syndrome ◽  
Cerebral Cortex ◽  
Amyloid Precursor Protein ◽  
Neuronal Cells ◽  
Precursor Protein ◽  
Trisomy 16

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

2006 ◽  
Vol 84 (6) ◽  
pp. 1303-1310 ◽  
Author(s):  
Patricia Opazo ◽  
Katherine Saud ◽  
Michelle de Saint Pierre ◽  
Ana María Cárdenas ◽  
David D. Allen ◽  
...  
Keyword(s):  
Animal Model ◽  
Down Syndrome ◽  
Cerebral Cortex ◽  
Amyloid Precursor Protein ◽  
Cell Line ◽  
Precursor Protein ◽  
Trisomy 16 ◽  
Cholinergic Function ◽  
A Cell

Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome

2010 ◽  
Vol 470 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Christian Arriagada ◽  
Miguel Bustamante ◽  
Illani Atwater ◽  
Eduardo Rojas ◽  
Raúl Caviedes ◽  
...  
Keyword(s):  
Animal Model ◽  
Down Syndrome ◽  
Cerebral Cortex ◽  
Cell Line ◽  
Trisomy 16 ◽  
Amyloid Accumulation ◽  
A Cell

Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome

2011 ◽  
Vol 22 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Mario A. Acuña ◽  
Ramón Pérez-Nuñez ◽  
Jorge Noriega ◽  
Ana María Cárdenas ◽  
Juan Bacigalupo ◽  
...  
Keyword(s):  
Animal Model ◽  
Down Syndrome ◽  
Cerebral Cortex ◽  
Cell Line ◽  
Neuronal Cell ◽  
Calcium Currents ◽  
Trisomy 16 ◽  
Fetal Mouse ◽  
Neuronal Cell Line ◽  
Voltage Dependent

Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

2008 ◽  
Vol 209 (1) ◽  
pp. 234-242 ◽  
Author(s):  
Guillermo Rojas ◽  
Ana María Cárdenas ◽  
Paola Fernández-Olivares ◽  
Takeshi Shimahara ◽  
Juan Segura-Aguilar ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Amyloid Precursor Protein ◽  
Intracellular Calcium ◽  
Cell Line ◽  
Neuronal Cell ◽  
Precursor Protein ◽  
Trisomy 16 ◽  
Neuronal Cell Line

Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

2002 ◽  
Vol 326 (1) ◽  
pp. 64-66 ◽  
Author(s):  
Kozo Motonaga ◽  
Masayuki Itoh ◽  
Laurence E. Becker ◽  
Yu-ichi Goto ◽  
Sachio Takashima
Keyword(s):  
Down Syndrome ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Elevated Expression
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