Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats

2009 ◽  
Vol 467 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Kristina Magnusson ◽  
Anders Hånell ◽  
Igor Bazov ◽  
Fredrik Clausen ◽  
Qin Zhou ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Morris Water Maze ◽  
Water Maze ◽  
Male Rats ◽  
Maze Performance ◽  
Nandrolone Decanoate ◽  
Prodynorphin Mrna

3α-diol administration decreases hippocampal PKA (II) mRNA expression and impairs Morris water maze performance in adult male rats

2015 ◽  
Vol 280 ◽  
pp. 149-159 ◽  
Author(s):  
Somayeh Assadian Narenji ◽  
Nasser Naghdi ◽  
Kayhan Azadmanesh ◽  
Rosita Edalat
Keyword(s):  
Mrna Expression ◽  
Morris Water Maze ◽  
Adult Male ◽  
Water Maze ◽  
Male Rats ◽  
Maze Performance

The timing of maternal separation affects morris water maze performance and long-term potentiation in male rats

2013 ◽  
Vol 56 (5) ◽  
pp. 1102-1109 ◽  
Author(s):  
Xiujing Cao ◽  
Shenghai Huang ◽  
Jiejie Cao ◽  
Tingting Chen ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maternal Separation ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Maze Performance ◽  
Term Potentiation

scholarly journals Beneficial effect of retigabine on memory in rats receiving ethanol

2020 ◽  
Author(s):  
Ewa Zwierzyńska ◽  
Agata Krupa-Burtnik ◽  
Bogusława Pietrzak
Keyword(s):  
Beneficial Effect ◽  
Fear Conditioning ◽  
Morris Water Maze ◽  
Water Maze ◽  
Experimental Models ◽  
Male Rats ◽  
Ethanol Administration ◽  
Free Access ◽  
Oral Gavage ◽  
The Impact

Abstract Background Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits. This study is focused on the impact of retigabine on memory processes in male rats receiving alcohol. Methods Memory was evaluated in various experimental models: Morris water maze, Contextual, and Cued Fear Conditioning tests. Retigabine was administered for 3 weeks directly to the stomach via oral gavage at a dose of 10 mg/kg. Rats received also 20% ethanol (5 g/kg/day in two doses) via oral gavage for 3 weeks and had free access to 5% ethanol in the afternoon and at night. Morris water maze was performed after 1 and 3 weeks of ethanol administration and after 1 week from the discontinuation of ethanol administration. Contextual and Cued Fear Conditioning tests were carried out after 24 h and 72 h of alcohol discontinuation. Results The drug significantly decreased ethanol-induced memory disturbances during alcohol administration as well as slightly improved learning processes after the discontinuation of ethanol administration. Conclusions This beneficial effect of retigabine-ethanol interaction on memory may be a relevant element of the drug’s impact on the development of addiction.

Effects of prenatal exposure to cocaine on Morris water maze performance in adult rats.

1995 ◽  
Vol 109 (4) ◽  
pp. 734-743 ◽  
Author(s):  
Charles J. Heyser ◽  
Norman E. Spear ◽  
Linda Patia Spear
Keyword(s):  
Morris Water Maze ◽  
Prenatal Exposure ◽  
Water Maze ◽  
Maze Performance ◽  
Adult Rats
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