β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration

2010 ◽  
Vol 485 (3) ◽  
pp. 162-166 ◽  
Author(s):  
Mirsada Čaušević ◽  
Umbreen Farooq ◽  
Simon Lovestone ◽  
Richard Killick
Keyword(s):  
Amyloid Precursor Protein ◽  
Tau Protein ◽  
Brain Regions ◽  
Precursor Protein ◽  
Protein Levels ◽  
Human Cerebellum ◽  
Β Amyloid

Effects of altered RTN3 expression on BACE1 activity and Alzheimer’s neuritic plaques

2017 ◽  
Vol 28 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Md Golam Sharoar ◽  
Riqiang Yan
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Neuritic Plaques ◽  
Amyloid Peptides ◽  
Protein Levels ◽  
Bace1 Expression ◽  
Β Amyloid ◽  
Tubular Endoplasmic Reticulum ◽  
Bace1 Activity

AbstractReticulon 3 (RTN3), which is a member of the reticulon family of proteins, has a biochemical function of shaping tubular endoplasmic reticulum. RTN3 has also been found to interact with β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which initiates the generation of β-amyloid peptides (Aβ) from amyloid precursor protein. Aβ is the major proteinaceous component in neuritic plaques, which constitute one of the major pathological features in brains of Alzheimer’s disease (AD) patients. Mice deficient in or overexpressing RTN3 have altered amyloid deposition through effects on BACE1 expression and activity. In this review, we will summarize the current findings concerning the role of RTN3 in AD pathogenesis and demonstrate that RTN3 protein levels act as age-dependent modulators of BACE1 activity and Aβ deposition during the pathogenic progression of AD.

scholarly journals Loss of Function ofATXN1Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein

2010 ◽  
Vol 285 (12) ◽  
pp. 8515-8526 ◽  
Author(s):  
Can Zhang ◽  
Andrew Browne ◽  
Daniel Child ◽  
Jason R. DiVito ◽  
Jesse A. Stevenson ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Protein ◽  
Loss Of Function ◽  
Protein Levels ◽  
Β Protein ◽  
Β Amyloid
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