scholarly journals Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury

2021 ◽  
Vol 765 ◽  
pp. 136260
Author(s):  
Agnieszka Lukomska ◽  
Juhwan Kim ◽  
Bruce A. Rheaume ◽  
Jian Xing ◽  
Alexela Hoyt ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Axon Regeneration ◽  
Elongation Factor ◽  
Transcriptional Elongation ◽  
Optic Nerve Injury

scholarly journals Human Periodontal Ligament-Derived Stem Cells Promote Retinal Ganglion Cell Survival and Axon Regeneration After Optic Nerve Injury

Stem Cells ◽  
2018 ◽  
Vol 36 (6) ◽  
pp. 844-855 ◽  
Author(s):  
Ling-Ping Cen ◽  
Tsz Kin Ng ◽  
Jia-Jian Liang ◽  
Xi Zhuang ◽  
Xiaowu Yao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Nerve Injury ◽  
Periodontal Ligament ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Optic Nerve Injury ◽  
Retinal Ganglion Cell Survival

Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury

2014 ◽  
Vol 581 ◽  
pp. 89-93 ◽  
Author(s):  
Kentaro Semba ◽  
Kazuhiko Namekata ◽  
Atsuko Kimura ◽  
Chikako Harada ◽  
Takashi Katome ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
P38 Mapk ◽  
Axon Regeneration ◽  
Optic Nerve Injury

scholarly journals Zinc chelation and Klf9 knockdown cooperatively promote axon regeneration after optic nerve injury

2018 ◽  
Vol 300 ◽  
pp. 22-29 ◽  
Author(s):  
Ephraim F. Trakhtenberg ◽  
Yiqing Li ◽  
Qian Feng ◽  
Janice Tso ◽  
Paul A. Rosenberg ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Axon Regeneration ◽  
Optic Nerve Injury ◽  
Zinc Chelation

scholarly journals Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury

PLoS Genetics ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. e1009885
Author(s):  
Rody Kingston ◽  
Dwarkesh Amin ◽  
Sneha Misra ◽  
Jeffrey M. Gross ◽  
Takaaki Kuwajima
Keyword(s):  
Optic Nerve ◽  
Nerve Injury ◽  
Serotonin Transporter ◽  
Molecular Mechanisms ◽  
Axon Regeneration ◽  
Transmembrane Protein ◽  
Molecular Axis ◽  
Retinal Ganglion ◽  
Optic Nerve Injury ◽  
Integrin Β3

Molecular insights into the selective vulnerability of retinal ganglion cells (RGCs) in optic neuropathies and after ocular trauma can lead to the development of novel therapeutic strategies aimed at preserving RGCs. However, little is known about what molecular contexts determine RGC susceptibility. In this study, we show the molecular mechanisms underlying the regional differential vulnerability of RGCs after optic nerve injury. We identified RGCs in the mouse peripheral ventrotemporal (VT) retina as the earliest population of RGCs susceptible to optic nerve injury. Mechanistically, the serotonin transporter (SERT) is upregulated on VT axons after injury. Utilizing SERT-deficient mice, loss of SERT attenuated VT RGC death and led to robust retinal axon regeneration. Integrin β3, a factor mediating SERT-induced functions in other systems, is also upregulated in RGCs and axons after injury, and loss of integrin β3 led to VT RGC protection and axon regeneration. Finally, RNA sequencing analyses revealed that loss of SERT significantly altered molecular signatures in the VT retina after optic nerve injury, including expression of the transmembrane protein, Gpnmb. GPNMB is rapidly downregulated in wild-type, but not SERT- or integrin β3-deficient VT RGCs after injury, and maintaining expression of GPNMB in RGCs via AAV2 viruses even after injury promoted VT RGC survival and axon regeneration. Taken together, our findings demonstrate that the SERT-integrin β3-GPNMB molecular axis mediates selective RGC vulnerability and axon regeneration after optic nerve injury.

scholarly journals Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats

2016 ◽  
Vol 525 (2) ◽  
pp. 380-388 ◽  
Author(s):  
Kevin K. Park ◽  
Xueting Luo ◽  
Skyler J. Mooney ◽  
Benjamin J. Yungher ◽  
Stephane Belin ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Nerve Injury ◽  
Retinal Ganglion Cell ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Optic Nerve Injury ◽  
Retinal Ganglion Cell Survival

scholarly journals Combined Application of BDNF to the Eye and Brain Enhances Ganglion Cell Survival and Function in the Cat after Optic Nerve Injury

2010 ◽  
Vol 51 (1) ◽  
pp. 327 ◽  
Author(s):  
Arthur J. Weber ◽  
Suresh Viswanáthan ◽  
Chidambaram Ramanathan ◽  
Christine D. Harman
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Nerve Injury ◽  
Optic Nerve Injury ◽  
Combined Application ◽  
And Function

scholarly journals Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in the rat retina upon optic nerve injury

2015 ◽  
Vol 21 (1) ◽  
pp. 167-178 ◽  
Author(s):  
Thomas Schmidt ◽  
Dietmar Fischer ◽  
Anastasia Andreadaki ◽  
Britta Bartelt-Kirbach ◽  
Nikola Golenhofen
Keyword(s):  
Optic Nerve ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Nerve Injury ◽  
Small Heat Shock Proteins ◽  
Optic Nerve Injury ◽  
Rat Retina ◽  
Αb Crystallin ◽  
Shock Proteins
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