The relationship between childhood and adolescent life adversities and adolescent depressive symptoms: The differential role of gender

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

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Pain intensity and physical performance among individuals with fibromyalgia in mid-to-late life: The influence of depressive symptoms

Journal of Health Psychology ◽

10.1177/13591053211009286 ◽

2021 ◽

pp. 135910532110092

Author(s):

Dylan G Serpas ◽

Laura Zettel-Watson ◽

Barbara J Cherry

Keyword(s):

Depressive Symptoms ◽

Pain Intensity ◽

Physical Performance ◽

Walk Test ◽

Mediation Analyses ◽

Mediating Role ◽

6 Minute Walk Test ◽

The Relationship ◽

Minute Walk

This study investigated the mediating role of depressive symptoms among 147 middle-aged and older adults with FM in the relationship between pain intensity and 4 objective measures of physical performance: Fullerton Advanced Balance scale (FAB), 6-Minute Walk Test (6MWT), 30-Second Chair Stand (30SCS), and 8-Foot Up and Go Test (8FUPGT). Asymptotic mediation analyses revealed that depressive symptoms fully mediated the relationship between pain intensity and FAB (95% CI [−0.40, −0.10]) and 8FUPGT (CI [0.02, 0.11]) and partially mediated the relationship to 6MWT (CI [−9.15, −2.20]) and 30SCS (CI [−0.29, −0.06]). Findings support the evaluation of co-morbid depression in FM.

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Satisfaction with Life: Mediating Role in the Relationship between Depressive Symptoms and Coping Mechanisms

Healthcare ◽

10.3390/healthcare9070787 ◽

2021 ◽

Vol 9 (7) ◽

pp. 787

Author(s):

Daniela Almeida ◽

Diogo Monteiro ◽

Filipe Rodrigues

Keyword(s):

Life Satisfaction ◽

Depressive Symptoms ◽

Coping Strategies ◽

Satisfaction With Life ◽

Well Being ◽

Coping Mechanisms ◽

Significant Positive Association ◽

Mediating Role ◽

The Relationship

The purpose of this study was to analyze the mediating role of life satisfaction in the relationship between fourteen coping strategies and depressive symptoms in the Portuguese population. To undertake this work, 313 Portuguese adults aged 18 to 70 years (M = 30.73; SD = 10.79) were invited to participate in this study. Their participation was completely voluntary, and participants granted and signed informed consent previously to the filling of the validated Portuguese questionnaires. These questionnaires measured depressive symptoms, coping, and life satisfaction. The results revealed that life satisfaction displayed a mediating role in the relationship between adaptive coping mechanisms, specifically between active coping, planning, reinterpretation, and acceptance and depressive symptoms, showing a negative and significant indirect effect. Maladaptive coping mechanisms of self-blame, denial, self-distraction, disengagement, and substance use had a significant positive association with depressive symptoms, considering the mediating role of satisfaction with life. Current investigation provides initial evidence of how each coping mechanism is associated with satisfaction with life and depressive symptoms. This study clearly demonstrates that not all coping strategies are capable of influencing well-being indicators and that health professionals should focus on endorsing those that are significantly associated with lowering depressive symptoms and increasing overall satisfaction with life.

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