Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: An in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4

2006 ◽  
Vol 55 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Akihide Yamashita ◽  
Koshi Makita ◽  
Toshihiko Kuroiwa ◽  
Kohichi Tanaka
Keyword(s):  
Cell Death ◽  
Cardiac Arrest ◽  
Purkinje Cell ◽  
Glutamate Transporters ◽  
In Vivo Study ◽  
Purkinje Cell Death

Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress

2019 ◽  
Vol 320 ◽  
pp. 112983 ◽  
Author(s):  
Jeong Hwi Cho ◽  
Hyun-Jin Tae ◽  
In-Shik Kim ◽  
Minah Song ◽  
Hyunjung Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Cardiac Arrest ◽  
Purkinje Cell ◽  
Cerebellar Purkinje Cell ◽  
Purkinje Cell Death ◽  
Asphyxial Cardiac Arrest

scholarly journals DNA damage in tissue-resident macrophages leads to age-related neurodegeneration

2021 ◽  
Author(s):  
George garinis ◽  
Katerina Gkirtzimanaki ◽  
Edisona Tsakani ◽  
Ermioni Arvanitaki ◽  
Electra Nenedaki ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Purkinje Cell ◽  
The Elderly ◽  
Type I ◽  
Age Related ◽  
Purkinje Cell Death ◽  
Repair Defect ◽  
The Brain

Abstract Neurodegenerative disorders are a growing challenge for the elderly yet their etiology remains elusive. Here, we show that persistent DNA damage in tissue-resident macrophages carrying an ERCC1-XPF DNA repair defect leads to cerebellar ataxia in mice. We find that cytoplasmic chromatin fragments accumulate in the brain microglia of progeroid and naturally aged mice stimulating a type-I Interferon (IFN-I) response and are then packaged in extracellular vesicles (EVs) leading to Purkinje cell death and neurodegeneration in Er1CX/− animals. To reduce neuroinflammation, we developed an EV-based strategy to deliver recombinant DNase I specifically in inflamed Er1CX/− microglia in vivo. Our approach rapidly removes dsDNAs from the cytoplasm of microglial cells and in secreted EVs; it alleviates the IFN-I response, decreases Purkinje cell death and delays the onset of neuronal decline in Er1CX/− animals. Thus, brain microglia causally contribute to neurodegeneration allowing for the development of promising therapeutic strategies against age-related neuroinflammation.

PURKINJE CELL DEATH IN TRANSGENIC MICE EXPRESSING AN INTACT OR TRUNCATED FORM OF SV40 T ANTIGEN

1993 ◽  
Vol 52 (3) ◽  
pp. 286
Author(s):  
H. B. Clark ◽  
H. T. Orr ◽  
R. Ehlenfeldt ◽  
W. S. Yunis ◽  
R. M. Feddersen
Keyword(s):  
Cell Death ◽  
Transgenic Mice ◽  
Purkinje Cell ◽  
T Antigen ◽  
Sv40 T Antigen ◽  
Truncated Form ◽  
Purkinje Cell Death

scholarly journals Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease

2015 ◽  
Vol 7 (276) ◽  
pp. 276ra26-276ra26 ◽  
Author(s):  
Charles H. Vite ◽  
Jessica H. Bagel ◽  
Gary P. Swain ◽  
Maria Prociuk ◽  
Tracey U. Sikora ◽  
...  
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Cerebellar Dysfunction ◽  
Purkinje Cell Death ◽  
Niemann Pick

scholarly journals AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease

2017 ◽  
Vol 58 (3) ◽  
pp. 512-518 ◽  
Author(s):  
Chang Xie ◽  
Xue-Min Gong ◽  
Jie Luo ◽  
Bo-Liang Li ◽  
Bao-Liang Song
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Behavioral Abnormalities ◽  
Purkinje Cell Death

scholarly journals Inhibition of Protein Kinase C Prevents Purkinje Cell Death But Does Not Affect Axonal Regeneration

2002 ◽  
Vol 22 (9) ◽  
pp. 3531-3542 ◽  
Author(s):  
Abdel M. Ghoumari ◽  
Rosine Wehrlé ◽  
Chris I. De Zeeuw ◽  
Constantino Sotelo ◽  
Isabelle Dusart
Keyword(s):  
Cell Death ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Purkinje Cell ◽  
Axonal Regeneration ◽  
Kinase C ◽  
Purkinje Cell Death
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