Organization of motor cortical inputs in the globus pallidus via the subthalamic nucleus in the monkey

2007 ◽  
Vol 58 ◽  
pp. S151
Author(s):  
Hirokazu Iwamuro ◽  
Yoshihisa Tachibana ◽  
Nobuhito Saito ◽  
Atsushi Nambu
Keyword(s):  
Globus Pallidus ◽  
Subthalamic Nucleus ◽  
Motor Cortical ◽  
Cortical Inputs

Organization of Motor Cortical Inputs to the Subthalamic Nucleus in the Monkey

2009 ◽  
pp. 109-117 ◽  
Author(s):  
Hirokazu Iwamuro ◽  
Yoshihisa Tachibana ◽  
Nobuhito Saito ◽  
Atsushi Nambu
Keyword(s):  
Subthalamic Nucleus ◽  
Motor Cortical ◽  
Cortical Inputs

scholarly journals Distinct roles for motor cortical and thalamic inputs to striatum during motor learning and execution

2019 ◽  
Author(s):  
Steffen B. E. Wolff ◽  
Raymond Ko ◽  
Bence P. Ölveczky
Keyword(s):  
Motor Cortex ◽  
Motor Learning ◽  
Learning Process ◽  
Brain Areas ◽  
Thalamic Neurons ◽  
Cortical Input ◽  
Motor Circuits ◽  
Motor Network ◽  
Motor Cortical ◽  
Cortical Inputs

AbstractThe acquisition and execution of learned motor sequences are mediated by a distributed motor network, spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog in this network, yet how its two main inputs, from motor cortex and thalamus respectively, contribute to its role in motor learning and execution remains largely unknown. To address this, we trained rats in a task that produces highly stereotyped and idiosyncratic motor sequences. We found that motor cortical input to the sensorimotor striatum is critical for the learning process, but after the behaviors were consolidated, this corticostriatal pathway became dispensable. Functional silencing of striatal-projecting thalamic neurons, however, disrupted the execution of the learned motor sequences, causing rats to revert to behaviors produced early in learning and preventing them from re-learning the task. These results show that the sensorimotor striatum is a conduit through which motor cortical inputs can drive experience-dependent changes in subcortical motor circuits, likely at thalamostriatal synapses.

Comparison between subthalamic nucleus and globus pallidus internus stimulation for postural performance in Parkinson's disease

2004 ◽  
Vol 19 (2) ◽  
pp. 172-183 ◽  
Author(s):  
Laura Rocchi ◽  
Lorenzo Chiari ◽  
Angelo Cappello ◽  
Anne Gross ◽  
Fay B. Horak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Globus Pallidus ◽  
Subthalamic Nucleus ◽  
Globus Pallidus Internus ◽  
Postural Performance
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