A train of electrical pulses applied to the primary auditory cortex evokes a conditioned response in guinea pigs

2011 ◽  
Vol 71 (1) ◽  
pp. 103-106 ◽  
Author(s):  
Yuji Okuda ◽  
Hiroshi Shikata ◽  
Wen-Jie Song
2010 ◽  
Vol 68 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Kazuya Saitoh ◽  
Shinji Inagaki ◽  
Masataka Nishimura ◽  
Hideo Kawaguchi ◽  
Wen-Jie Song

Neuroreport ◽  
1998 ◽  
Vol 9 (15) ◽  
pp. 3421-3425 ◽  
Author(s):  
Yutaka Hosokawa ◽  
Junsei Horikawa ◽  
Masahiro Nasu ◽  
Shunji Sugimoto ◽  
Ikuo Taniguchi

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259055
Author(s):  
Mutsumi Kenmochi ◽  
Kentaro Ochi ◽  
Hirotsugu Kinoshita ◽  
Yasuhiro Miyamoto ◽  
Izumi Koizuka

Objective To investigate the effect of systemic administration of salicylate as a tinnitus inducing drug in the auditory cortex of guinea pigs. Methods Extracellular recording of spikes of the primary auditory cortex and dorsocaudal areas in healthy male albino Hartley guinea pigs was continuously performed (pre- and post-salicylate). Results We recorded 160 single units in the primary auditory cortex from five guinea pigs and 156 single units in the dorsocaudal area from another five guinea pigs. The threshold was significantly elevated after the administration of salicylate in both the primary auditory cortex and dorsocaudal areas. The Q10dB value was significantly increased in the primary auditory cortex, whereas it has significantly decreased in the dorsocaudal area. Spontaneous firing activity was significantly decreased in the primary auditory cortex, whereas it has significantly increased in the dorsocaudal area. Conclusion Salicylate induces significant changes in single units of both stimulated and spontaneous activity in the auditory cortex of guinea pigs. The spontaneous activity changed differently depending on its cortical areas, which may be due to the neural elements that generate tinnitus.


2013 ◽  
Vol 40 (4) ◽  
pp. 365
Author(s):  
Qiao-Zhen QI ◽  
Wen-Juan SI ◽  
Feng LUO ◽  
Xin WANG

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