A deep learning algorithm for sleep stage scoring in mice based on a multimodal network with fine-tuning technique

Author(s):  
Keishi Akada ◽  
Takuya Yagi ◽  
Yuji Miura ◽  
Carsten T. Beuckmann ◽  
Noriyuki Koyama ◽  
...  
2020 ◽  
Vol 10 (4) ◽  
pp. 213 ◽  
Author(s):  
Ki-Sun Lee ◽  
Jae Young Kim ◽  
Eun-tae Jeon ◽  
Won Suk Choi ◽  
Nan Hee Kim ◽  
...  

According to recent studies, patients with COVID-19 have different feature characteristics on chest X-ray (CXR) than those with other lung diseases. This study aimed at evaluating the layer depths and degree of fine-tuning on transfer learning with a deep convolutional neural network (CNN)-based COVID-19 screening in CXR to identify efficient transfer learning strategies. The CXR images used in this study were collected from publicly available repositories, and the collected images were classified into three classes: COVID-19, pneumonia, and normal. To evaluate the effect of layer depths of the same CNN architecture, CNNs called VGG-16 and VGG-19 were used as backbone networks. Then, each backbone network was trained with different degrees of fine-tuning and comparatively evaluated. The experimental results showed the highest AUC value to be 0.950 concerning COVID-19 classification in the experimental group of a fine-tuned with only 2/5 blocks of the VGG16 backbone network. In conclusion, in the classification of medical images with a limited number of data, a deeper layer depth may not guarantee better results. In addition, even if the same pre-trained CNN architecture is used, an appropriate degree of fine-tuning can help to build an efficient deep learning model.


2021 ◽  
Author(s):  
Tian Xiang Gao ◽  
Jia Yi Li ◽  
Yuji Watanabe ◽  
Chi Jung Hung ◽  
Akihiro Yamanaka ◽  
...  

Abstract Sleep-stage classification is essential for sleep research. Various automatic judgment programs including deep learning algorithms using artificial intelligence (AI) have been developed, but with limitations in data format compatibility, human interpretability, cost, and technical requirements. We developed a novel program called GI-SleepNet, generative adversarial network (GAN)-assisted image-based sleep staging for mice that is accurate, versatile, compact, and easy to use. In this program, electroencephalogram and electromyography data are first visualized as images and then classified into three stages (wake, NREM, and REM) by a supervised image learning algorithm. To increase the accuracy, we adopted GAN and artificially generated fake REM sleep data to equalize the number of stages. This resulted in improved accuracy, and as few as one mouse data yielded significant accuracy. Because of its image-based nature, it is easy to apply to data of different formats, of different species of animals, and even outside of sleep research. Image data can be easily understood by humans, thus especially confirmation by experts is easy when there are some anomalies of prediction. Because deep learning of images is one of the leading fields in AI, numerous algorithms are also available.


2021 ◽  
Vol 3 (4) ◽  
pp. 581-597
Author(s):  
Tianxiang Gao ◽  
Jiayi Li ◽  
Yuji Watanabe ◽  
Chijung Hung ◽  
Akihiro Yamanaka ◽  
...  

Sleep-stage classification is essential for sleep research. Various automatic judgment programs, including deep learning algorithms using artificial intelligence (AI), have been developed, but have limitations with regard to data format compatibility, human interpretability, cost, and technical requirements. We developed a novel program called GI-SleepNet, generative adversarial network (GAN)-assisted image-based sleep staging for mice that is accurate, versatile, compact, and easy to use. In this program, electroencephalogram and electromyography data are first visualized as images, and then classified into three stages (wake, NREM, and REM) by a supervised image learning algorithm. To increase its accuracy, we adopted GAN and artificially generated fake REM sleep data to equalize the number of stages. This resulted in improved accuracy, and as little as one mouse’s data yielded significant accuracy. Due to its image-based nature, the program is easy to apply to data of different formats, different species of animals, and even outside sleep research. Image data can be easily understood; thus, confirmation by experts is easily obtained, even when there are prediction anomalies. As deep learning in image processing is one of the leading fields in AI, numerous algorithms are also available.


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