Association and interaction of TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study

2022 ◽  
Author(s):  
Xiaoyan Liang ◽  
Cuicui Liu ◽  
Keke Liu ◽  
Lin Cong ◽  
Yongxiang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Population Based ◽  
Population Based Study ◽  
Chinese Older Adults

scholarly journals Interaction effects between variants in TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study

2021 ◽  
Author(s):  
liang xiaoyan ◽  
Cuicui Liu ◽  
Keke Liu ◽  
Lin Cong ◽  
Yongxiang Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Polymerase Chain Reaction Amplification ◽  
Amyloid Β ◽  
Population Based ◽  
Linear Regression Models ◽  
Population Based Study ◽  
Chinese Older Adults ◽  
Risk Alleles

Abstract Background Emerging evidence has linked TOMM40 and PVRL2 polymorphisms with Alzheimer’s disease (AD). We examined their associations with AD and plasma AD biomarkers and interaction on AD risk among Chinese older adults. Methods This population-based study included 4876 participants (age ≥ 65 years, 57.2% women) from MIND-China. TOMM40(rs2075650) and PVRL2(rs6859) polymorphisms were detected using multiple-polymerase chain reaction amplification. Plasma Aβ40, Aβ42, and t-tau were measured using SIMOA in a subsample (n = 1257). Data was analyzed using multiple logistic and general linear regression models. Results AD was diagnosed in 182 participants. The multi-adjusted odds ratio of AD was 6.24(95%CI 1.73–22.48) for TOMM40GG (vs. AA), 1.47(0.89–2.42) for PVRL2AA (vs. GG), and 12.87(3.97–41.73) for having both risk alleles (Pinteraction=0.0003). In the plasma biomarker subsample, TOMM40GG was significantly associated with lower plasma Aβ42 and the Aβ42-to-Aβ40 ratio (p < 0.05). Conclusions TOMM40 and PVRL2 genes could interact to substantially increase the likelihood of AD, possibly through influencing Aβ metabolism.

scholarly journals Dissociated amyloid-β antibody levels as a serum biomarker for the progression of Alzheimer’s disease: A population-based study

2010 ◽  
Vol 45 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Katarzyna A. Gustaw-Rothenberg ◽  
Sandra L. Siedlak ◽  
David J. Bonda ◽  
Alan Lerner ◽  
Massimo Tabaton ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Population Based ◽  
Serum Biomarker ◽  
Population Based Study ◽  
Antibody Levels

Cortisol, Amyloid-β, and Reserve Predicts Alzheimer’s Disease Progression for Cognitively Normal Older Adults

2019 ◽  
Vol 70 (2) ◽  
pp. 553-562 ◽  
Author(s):  
Chinedu T. Udeh-Momoh ◽  
Bowen Su ◽  
Stephanie Evans ◽  
Bang Zheng ◽  
Shireen Sindi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Amyloid Β ◽  
Cognitively Normal

Use of medications and functional dependence among Chinese older adults in a rural community: A population-based study

2015 ◽  
Vol 15 (12) ◽  
pp. 1242-1248
Author(s):  
Yajun Liang ◽  
Kristina Johnell ◽  
Zhongrui Yan ◽  
Chuanzhu Cai ◽  
Hui Jiang ◽  
...  
Keyword(s):  
Older Adults ◽  
Rural Community ◽  
Functional Dependence ◽  
Population Based ◽  
Population Based Study ◽  
Chinese Older Adults
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