scholarly journals Comparison of structural covariance with functional connectivity approaches exemplified by an investigation of the left anterior insula

NeuroImage ◽  
2014 ◽  
Vol 99 ◽  
pp. 269-280 ◽  
Author(s):  
Mareike Clos ◽  
Claudia Rottschy ◽  
Angela R. Laird ◽  
Peter T. Fox ◽  
Simon B. Eickhoff
Keyword(s):  
Functional Connectivity ◽  
Anterior Insula ◽  
Structural Covariance

Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response

2016 ◽  
Vol 124 (4) ◽  
pp. 766-778 ◽  
Author(s):  
Catherine Elizabeth Warnaby ◽  
Marta Seretny ◽  
Roísín Ní Mhuircheartaigh ◽  
Richard Rogers ◽  
Saad Jbabdi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Insula ◽  
Cortical Region ◽  
Dorsolateral Prefrontal ◽  
Behavioral Responsiveness ◽  
Insula Cortex ◽  
Evoked Activity ◽  
The Right ◽  
Conjunction Analysis ◽  
External Stimuli

Abstract Background It has been postulated that a small cortical region could be responsible for the loss of behavioral responsiveness (LOBR) during general anesthesia. The authors hypothesize that any brain region demonstrating reduced activation to multisensory external stimuli around LOBR represents a key cortical gate underlying this transition. Furthermore, the authors hypothesize that this localized suppression is associated with breakdown in frontoparietal communication. Methods During both simultaneous electroencephalography and functional magnetic resonance imaging (FMRI) and electroencephalography data acquisition, 15 healthy volunteers experienced an ultraslow induction with propofol anesthesia while a paradigm of multisensory stimulation (i.e., auditory tones, words, and noxious pain stimuli) was presented. The authors performed separate analyses to identify changes in (1) stimulus-evoked activity, (2) functional connectivity, and (3) frontoparietal synchrony associated with LOBR. Results By using an FMRI conjunction analysis, the authors demonstrated that stimulus-evoked activity was suppressed in the right dorsal anterior insula cortex (dAIC) to all sensory modalities around LOBR. Furthermore, the authors found that the dAIC had reduced functional connectivity with the frontoparietal regions, specifically the dorsolateral prefrontal cortex and inferior parietal lobule, after LOBR. Finally, reductions in the electroencephalography power synchrony between electrodes located in these frontoparietal regions were observed in the same subjects after LOBR. Conclusions The authors conclude that the dAIC is a potential cortical gate responsible for LOBR. Suppression of dAIC activity around LOBR was associated with disruption in the frontoparietal networks that was measurable using both electroencephalography synchrony and FMRI connectivity analyses.

Altered resting state functional connectivity of anterior insula in young smokers

2016 ◽  
Vol 11 (1) ◽  
pp. 155-165 ◽  
Author(s):  
Yanzhi Bi ◽  
Kai Yuan ◽  
Yanyan Guan ◽  
Jiadong Cheng ◽  
Yajuan Zhang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Anterior Insula ◽  
Resting State Functional Connectivity ◽  
Young Smokers

scholarly journals Resting State Functional Connectivity Predicts Future Changes in Sedentary Behavior

2021 ◽  
Author(s):  
Timothy P. Morris ◽  
Aaron Kucyi ◽  
Sheeba Arnold Anteraper ◽  
Maiya Rachel Geddes ◽  
Alfonso Nieto-Castañon ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Exercise Intervention ◽  
Supplementary Motor Area ◽  
Anterior Insula ◽  
Motor Area ◽  
Anterior Cingulate ◽  
Sedentary Behaviors ◽  
Resting State Functional Connectivity ◽  
The Right

AbstractInformation about a person’s available energy resources is integrated in daily behavioral choices that weigh motor costs against expected rewards. It has been posited that humans have an innate attraction towards effort minimization and that executive control is required to overcome this prepotent disposition. With sedentary behaviors increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths, understanding the predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. In 64 healthy older adults participating in a 6-month aerobic exercise intervention, we use neuroimaging (resting state functional connectivity), baseline measures of executive function and accelerometer measures of time spent sedentary to predict future changes in objectively measured time spent sedentary in daily life. Using cross-validation and bootstrap resampling, our results demonstrate that functional connectivity between 1) the anterior cingulate cortex and the supplementary motor area and 2) the right anterior insula and the left temporoparietal/temporooccipital junction, predict changes in time spent sedentary, whereas baseline cognitive, behavioral and demographic measures do not. Previous research has shown activation in and between the anterior cingulate and supplementary motor area as well as in the right anterior insula during effort avoidance and tasks that integrate motor costs and reward benefits in effort-based decision making. Our results add important knowledge toward understanding mechanistic associations underlying complex sedentary behaviors.

Reduced functional connectivity between salience and visual networks in migraine with aura

Cephalalgia ◽  
2015 ◽  
Vol 36 (1) ◽  
pp. 53-66 ◽  
Author(s):  
David M Niddam ◽  
Kuan-Lin Lai ◽  
Jong-Ling Fuh ◽  
Chih-Ying Naomi Chuang ◽  
Wei-Ta Chen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Visual Processing ◽  
Brain Connectivity ◽  
Anterior Insula ◽  
Cognitive Networks ◽  
Visual Aura ◽  
Compensatory Response ◽  
Visual Deficits ◽  
Headache Severity ◽  
Brain Functional Connectivity

Background Migraine with visual aura (MA) is associated with distinct visual disturbances preceding migraine attacks, but shares other visual deficits in between attacks with migraine without aura (MO). Here, we seek to determine if abnormalities specific to interictal MA patients exist in functional brain connectivity of intrinsic cognitive networks. In particular, these networks are involved in top-down modulation of visual processing. Methods Using resting-state functional magnetic resonance imaging, whole-brain functional connectivity maps were derived from seeds placed in the anterior insula and the middle frontal gyrus, key nodes of the salience and dorsal attention networks, respectively. Twenty-six interictal MA patients were compared with 26 matched MO patients and 26 healthy matched controls. Results The major findings were: connectivity between the anterior insula and occipital areas, including area V3A, was reduced in MA but not in MO. Connectivity changes between the anterior insula and occipital areas further correlated with the headache severity in MA only. Conclusions The unique pattern of connectivity changes found in interictal MA patients involved area V3A, an area previously implicated in aura generation. Hypoconnectivity to this and other occipital regions may either represent a compensatory response to occipital dysfunctions or predispose MA patients to the development of aura.

scholarly journals Moderating Effects of Harm Avoidance on Resting-State Functional Connectivity of the Anterior Insula

2018 ◽  
Vol 12 ◽  
Author(s):  
Ashley A. Huggins ◽  
Emily L. Belleau ◽  
Tara A. Miskovich ◽  
Walker S. Pedersen ◽  
Christine L. Larson
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Anterior Insula ◽  
Harm Avoidance ◽  
Moderating Effects ◽  
Resting State Functional Connectivity

Endogenous cortisol-related alterations of right anterior insula functional connectivity under acute stress

2020 ◽  
Vol 274 ◽  
pp. 231-238
Author(s):  
Yuyang Zhu ◽  
Yituo Wang ◽  
Zheng Yang ◽  
Lubin Wang ◽  
Xiangjun Hu
Keyword(s):  
Functional Connectivity ◽  
Acute Stress ◽  
Anterior Insula ◽  
Endogenous Cortisol

Increased interregional functional connectivity of anterior insula is associated with improved smoking cessation outcome

2019 ◽  
Vol 14 (2) ◽  
pp. 408-415
Author(s):  
Chao Wang ◽  
Zhujing Shen ◽  
Peiyu Huang ◽  
Wei Qian ◽  
Cheng Zhou ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Functional Connectivity ◽  
Anterior Insula ◽  
Smoking Cessation Outcome

scholarly journals Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

2021 ◽  
Author(s):  
O. Contreras-Rodriguez ◽  
M. Arnoriaga-Rodríguez ◽  
R. Miranda-Olivos ◽  
G. Blasco ◽  
C. Biarnés ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Functional Connectivity ◽  
Orbitofrontal Cortex ◽  
Executive Dysfunction ◽  
Structural Covariance ◽  
Gut Dysbiosis ◽  
Obesity Status ◽  
Subcortical Nuclei ◽  
Parietal Cortices

Abstract Background Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation.

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