Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI

The granular layer of the cerebellar cortex situated between the molecular and medullary layers is built up mainly of the perikarya of small interneurons, the granule cells intermingled with part of their own processes, mossy fiber terminals, fibers of passage and other less numerous intrinsic cells. Ultrastructurally they are characterized by a nucleus which occupies most of the cell body and a rim of cytoplasm. The nucleus exhibits some aggregates of chromatin and in some cells a nucleolus. In the cytoplasm very scarce organelles are observed (Fig.l). Their main synaptic connections are found, first, at the cerebellar glomerulus where granule dendrites are seen in postsynaptic position towards mossy fiber rosettes. Desmosomic attachments are observed between granule dendrites. Second, at the level of the molecular layer where parallel fiber terminals (ramifications of the peripheral axon ) are seen apposing Purkinje dendrite spines.

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P2-150: Glymphatic clearance impaired in a mouse model of tauopathy: Captured using contrast-enhanced MRI

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.688 ◽

2015 ◽

Vol 11 (7S_Part_11) ◽

pp. P544-P544

Author(s):

Ian F. Harrison ◽

Asif Machhada ◽

Niall Colgan ◽

Ozama Ismail ◽

James M. O'Callaghan ◽

...

Keyword(s):

Mouse Model ◽

Enhanced Mri ◽

Contrast Enhanced ◽

Contrast Enhanced Mri

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NEUROGLIA IN THE INTERNAL GRANULAR LAYER OF THE DEVELOPING RAT CEREBELLAR CORTEX

Neuropathology and Applied Neurobiology ◽

10.1111/j.1365-2990.1977.tb00582.x ◽

1977 ◽

Vol 3 (3) ◽

pp. 183-190 ◽

Cited By ~ 38

Author(s):

P. D. LEWIS ◽

Z. FüLÖP ◽

F. HAJÓS ◽

R. BALÁZS ◽

P. L. WOODHAMS

Keyword(s):

Cerebellar Cortex ◽

Granular Layer ◽

Internal Granular Layer ◽

Developing Rat

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A rare WHO Grade I Lesion of the Posterior Fossa with Recurrence Biological Behavior - Dysplastic Gangliocytoma of the Cerebellum: Case Report

Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery ◽

10.1055/s-0039-3402491 ◽

2020 ◽

Vol 39 (02) ◽

pp. 132-135

Author(s):

Leandro Pelegrini de Almeida ◽

Felipe Lourezon Schiavo ◽

Samir Cezimbra dos Santos ◽

William Mazzucco Nesi ◽

Eduardo Cambruzzi

Keyword(s):

Granular Layer ◽

Ganglion Cells ◽

Obstructive Hydrocephalus ◽

Molecular Layer ◽

Suppressor Gene ◽

World Health ◽

Biological Behavior ◽

Who Grade ◽

Dysplastic Gangliocytoma ◽

Internal Granular Layer

AbstractDysplastic gangliocytoma of the cerebellum (DGC) or Lhermitte-Duclos Disease is a rare lesion (World Health Organization [WHO] grade I) characterized by thickened folia and replacement of the internal granular layer by abnormal ganglion cells. More commonly, the compromised patients are young adults presenting ataxia, seizures, obstructive hydrocephalus, and increased intracranial pressure. Dysplastic gangliocytoma of the cerebellum is intimately associated with Cowden syndrome, a hereditary disorder caused by a germline mutation in the PTEN tumor suppressor gene on chromosome 10q23. Large neurons of DCG show vesicular nuclei with prominent nucleoli. Expansion of the internal granular layer determines vacuolization of the molecular layer and white matter, which can be related to the bright stripes identified on T2-weighted magnetic resonance imaging. Herein, the authors report a female patient who developed long- time recurrence of DGC and discuss pathological findings and differential diagnosis of this rare cerebellar lesion.

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