scholarly journals tDCS modulates effective connectivity during motor command following; a potential therapeutic target for disorders of consciousness

NeuroImage ◽  
2021 ◽  
pp. 118781
Author(s):  
Davide Aloi ◽  
Roya Jalali ◽  
Penelope Tilsley ◽  
R. Chris Miall ◽  
Davinia Fernández-Espejo
Keyword(s):  
Therapeutic Target ◽  
Effective Connectivity ◽  
Motor Command ◽  
Disorders Of Consciousness ◽  
Potential Therapeutic Target ◽  
Command Following

scholarly journals tDCS modulates effective connectivity during motor command following; a potential therapeutic target for disorders of consciousness

2021 ◽  
Author(s):  
Davide Aloi ◽  
Roya Jalali ◽  
Penelope Tilsley ◽  
R. Chris Miall ◽  
Davinia Fernández-Espejo
Keyword(s):  
Brain Activity ◽  
Effective Connectivity ◽  
Motor Command ◽  
Disorders Of Consciousness ◽  
Motor Deficits ◽  
Potential Therapeutic Target ◽  
Motor Responses ◽  
Cathodal Tdcs ◽  
Command Following

AbstractTranscranial direct current stimulation (tDCS) is attracting increasing interest as a potential therapeutic route for unresponsive patients with prolonged disorders of consciousness (PDOC). However, research to date has had mixed results. Here, we propose a new direction by directly addressing the mechanisms underlying lack of responsiveness in PDOC, and using these to define our targets and the success of our intervention in the healthy brain first. We used fMRI to characterise the effects of tDCS on brain activity and dynamics during command following, a task typically used to clinically assess awareness. Anodal tDCS over M1 and cathodal tDCS over the cerebellum led to long-range changes in thalamo-cortical coupling associated with the ability to produce motor responses to command. This suggests that tDCS may allow PDOC patients to overcome the motor deficits at the root of their reduced responsiveness, improving their rehabilitation options and quality of life as a result.

Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease

2016 ◽  
Vol 22 (10) ◽  
pp. 1305-1311 ◽  
Author(s):  
Juan Camilo Jurado-Coronel ◽  
Marco Avila-Rodriguez ◽  
Francisco Capani ◽  
Janneth Gonzalez ◽  
Valentina Echeverria Moran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Therapeutic Target ◽  
Acetylcholine Receptors ◽  
Potential Therapeutic Target ◽  
Nicotinic Acetylcholine

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

2020 ◽  
Vol 26 ◽  
Author(s):  
Yujie Shen ◽  
Yexiang Lin ◽  
Kai Liu ◽  
Jinlan Chen ◽  
Juanjuan Zhong ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Critical Role ◽  
Biological Functions ◽  
Potential Therapeutic Target ◽  
Considerable Evidence ◽  
Lncrna Xist ◽  
Nsclc Patients ◽  
The Relationship

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC. Methods: In this review, relevant researches involving in the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST exerts a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in NSCLC process, while XIST also functions at transcriptional levels. Conclusion: LncRNA XIST has potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

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