scholarly journals The EBAX-type Cullin-RING E3 Ligase and Hsp90 Guard the Protein Quality of the SAX-3/Robo Receptor in Developing Neurons

Neuron ◽  
2013 ◽  
Vol 79 (5) ◽  
pp. 903-916 ◽  
Author(s):  
Zhiping Wang ◽  
Yanli Hou ◽  
Xing Guo ◽  
Monique van der Voet ◽  
Mike Boxem ◽  
...  
Science ◽  
2019 ◽  
Vol 365 (6448) ◽  
pp. eaaw4912 ◽  
Author(s):  
Richard T. Timms ◽  
Zhiqian Zhang ◽  
David Y. Rhee ◽  
J. Wade Harper ◽  
Itay Koren ◽  
...  

The N-terminal residue influences protein stability through N-degron pathways. We used stability profiling of the human N-terminome to uncover multiple additional features of N-degron pathways. In addition to uncovering extended specificities of UBR E3 ligases, we characterized two related Cullin-RING E3 ligase complexes, Cul2ZYG11B and Cul2ZER1, that act redundantly to target N-terminal glycine. N-terminal glycine degrons are depleted at native N-termini but strongly enriched at caspase cleavage sites, suggesting roles for the substrate adaptors ZYG11B and ZER1 in protein degradation during apoptosis. Furthermore, ZYG11B and ZER1 were found to participate in the quality control of N-myristoylated proteins, in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. Thus, an additional N-degron pathway specific for glycine regulates the stability of metazoan proteomes.


2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryan J. Lumpkin ◽  
Richard W. Baker ◽  
Andres E. Leschziner ◽  
Elizabeth A. Komives

2015 ◽  
Vol 89 ◽  
pp. 1036-1048 ◽  
Author(s):  
Dhanendra Tomar ◽  
Paresh Prajapati ◽  
Julie Lavie ◽  
Kritarth Singh ◽  
Sripada Lakshmi ◽  
...  

2015 ◽  
Vol 169 (2) ◽  
pp. 1405-1417 ◽  
Author(s):  
Laurens Pauwels ◽  
Andrés Ritter ◽  
Jonas Goossens ◽  
Astrid Nagels Durand ◽  
Hongxia Liu ◽  
...  
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