scholarly journals Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze

Neuron ◽  
2019 ◽  
Vol 101 (1) ◽  
pp. 119-132.e4 ◽  
Author(s):  
Haibing Xu ◽  
Peter Baracskay ◽  
Joseph O’Neill ◽  
Jozsef Csicsvari
Keyword(s):  
Place Cells ◽  
Learned Behavior ◽  
Hippocampal Ca1 ◽  
Spatial Tasks

scholarly journals Alternating sequences of future and past behavior encoded within hippocampal theta oscillations

Science ◽  
2020 ◽  
Vol 370 (6513) ◽  
pp. 247-250 ◽  
Author(s):  
Mengni Wang ◽  
David J. Foster ◽  
Brad E. Pfeiffer
Keyword(s):  
Activity Patterns ◽  
Place Cells ◽  
Theta Oscillations ◽  
Retrospective Evaluation ◽  
Past Behavior ◽  
Hippocampal Ca1 ◽  
Ongoing Behavior ◽  
Theta Phase ◽  
Hippocampal Theta ◽  
And Storage

Neural networks display the ability to transform forward-ordered activity patterns into reverse-ordered, retrospective sequences. The mechanisms underlying this transformation remain unknown. We discovered that, during active navigation, rat hippocampal CA1 place cell ensembles are inherently organized to produce independent forward- and reverse-ordered sequences within individual theta oscillations. This finding may provide a circuit-level basis for retrospective evaluation and storage during ongoing behavior. Theta phase procession arose in a minority of place cells, many of which displayed two preferred firing phases in theta oscillations and preferentially participated in reverse replay during subsequent rest. These findings reveal an unexpected aspect of theta-based hippocampal encoding and provide a biological mechanism to support the expression of reverse-ordered sequences.

scholarly journals Framing Spatial Cognition: Neural Representations of Proximal and Distal Frames of Reference and Their Roles in Navigation

2011 ◽  
Vol 91 (4) ◽  
pp. 1245-1279 ◽  
Author(s):  
James J. Knierim ◽  
Derek A. Hamilton
Keyword(s):  
Coordinate System ◽  
Hippocampal Neurons ◽  
Place Cells ◽  
Spatial Behavior ◽  
Spatial Learning And Memory ◽  
Sources Of Information ◽  
Common View ◽  
Spatial Tasks ◽  
Spatial Specificity ◽  
Local Cues

The most common behavioral test of hippocampus-dependent, spatial learning and memory is the Morris water task, and the most commonly studied behavioral correlate of hippocampal neurons is the spatial specificity of place cells. Despite decades of intensive research, it is not completely understood how animals solve the water task and how place cells generate their spatially specific firing fields. Based on early work, it has become the accepted wisdom in the general neuroscience community that distal spatial cues are the primary sources of information used by animals to solve the water task (and similar spatial tasks) and by place cells to generate their spatial specificity. More recent research, along with earlier studies that were overshadowed by the emphasis on distal cues, put this common view into question by demonstrating primary influences of local cues and local boundaries on spatial behavior and place-cell firing. This paper first reviews the historical underpinnings of the “standard” view from a behavioral perspective, and then reviews newer results demonstrating that an animal's behavior in such spatial tasks is more strongly controlled by a local-apparatus frame of reference than by distal landmarks. The paper then reviews similar findings from the literature on the neurophysiological correlates of place cells and other spatially correlated cells from related brain areas. A model is proposed by which distal cues primarily set the orientation of the animal's internal spatial coordinate system, via the head direction cell system, whereas local cues and apparatus boundaries primarily set the translation and scale of that coordinate system.

scholarly journals A combinatorial postsynaptic molecular mechanism converts patterns of nerve impulses into the behavioral repertoire

2018 ◽  
Author(s):  
Maksym V. Kopanitsa ◽  
Louie N. van de Lagemaat ◽  
Nurudeen O. Afinowi ◽  
Douglas J. Strathdee ◽  
Karen E. Strathdee ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Genetic Study ◽  
Activity Patterns ◽  
Behavioral Responses ◽  
Behavioral Repertoire ◽  
Learned Behavior ◽  
Nerve Impulses ◽  
Ca1 Region ◽  
Hippocampal Ca1 Region ◽  
Hippocampal Ca1

AbstractHow is the information encoded within patterns of nerve impulses converted into diverse behavioral responses? To address this question, we conducted the largest genetic study to date of the electrophysiological and behavioral properties of synapses. Postsynaptic responses to elementary patterns of activity in the hippocampal CA1 region were measured in 58 lines of mice carrying mutations in the principal classes of excitatory postsynaptic proteins. A combinatorial molecular mechanism was identified in which distinct subsets of proteins amplified or attenuated responses across timescales from milliseconds to an hour. The same mechanism controlled the diversity and magnitude of innate and learned behavioral responses. PSD95 supercomplex proteins were central components of this synaptic machinery. The capacity of vertebrate synapses to compute activity patterns increased with genome evolution and is impaired by disease-relevant mutations. We propose that this species-conserved molecular mechanism converts the temporally encoded information in nerve impulses into the repertoire of innate and learned behavior.

scholarly journals Conjunctive spatial and idiothetic codes are topographically organized in the lateral septum

2020 ◽  
Author(s):  
Suzanne van der Veldt ◽  
Guillaume Etter ◽  
Fernanda Sosa ◽  
Coralie-Anne Mosser ◽  
Sylvain Williams
Keyword(s):  
Medial Septum ◽  
Place Cells ◽  
Lateral Septum ◽  
Head Direction ◽  
Neuronal Populations ◽  
Spatial Tuning ◽  
Hippocampal Ca1 ◽  
Memory Network ◽  
Anterior Posterior

AbstractThe relevance of the hippocampal spatial code for downstream neuronal populations – in particular its main subcortical output, the lateral septum (LS) - is still poorly understood. Here, we addressed this knowledge gap by first clarifying the organization of LS afferents and efferents via retrograde and anterograde trans-synaptic tracing. We found that mouse LS receives inputs from hippocampal subregions CA1, CA3, and subiculum, and in turn projects directly to the lateral hypothalamus (LH), ventral tegmental area (VTA), and medial septum (MS). Next, we functionally characterized the spatial tuning properties of LS GABAergic cells, the principal cells composing the LS, via calcium imaging combined with unbiased analytical methods. We identified a significant number of cells that are modulated by place (38.01%), speed (23.71%), acceleration (27.84%), and head-direction (23.09%), and conjunctions of these properties, with spatial tuning comparable to hippocampal CA1 and CA3 place cells. Bayesian decoding of position on the basis of LS place cells accurately reflected the location of the animal. The distributions of cells exhibiting these properties formed gradients along the anterior-posterior axis of the LS, directly reflecting the organization of hippocampal inputs to the LS. A portion of LS place cells showed stable fields over the course of multiple days, potentially reflecting long-term episodic memory. Together, our findings demonstrate that the LS accurately and robustly represents spatial and idiothetic information and is uniquely positioned to relay this information from the hippocampus to the VTA, LH, and MS, thus occupying a key position within this distributed spatial memory network.

The firing rate of hippocampal CA1 place cells is modulated with a circadian period

Hippocampus ◽  
2011 ◽  
Vol 22 (6) ◽  
pp. 1325-1337 ◽  
Author(s):  
Robert G.K. Munn ◽  
David K. Bilkey
Keyword(s):  
Firing Rate ◽  
Place Cells ◽  
Circadian Period ◽  
Hippocampal Ca1

scholarly journals Prefrontal cortical activity predicts the extra-place field spiking of hippocampal place cells

2020 ◽  
Author(s):  
Jai Y. Yu ◽  
Loren M. Frank
Keyword(s):  
Receptive Field ◽  
Receptive Fields ◽  
Cortical Activity ◽  
Place Cells ◽  
Theta Oscillations ◽  
Place Field ◽  
Prefrontal Cortical ◽  
Hippocampal Ca1 ◽  
Non Local ◽  
Hippocampal Theta

AbstractThe receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains unclear. We therefore contrasted the sparse, temporally isolated spiking of hippocampal CA1 place cells to the consistent, temporally adjacent spiking seen within their spatial receptive fields (“place fields”). We found that isolated spikes, which occur during locomotion, are more strongly phase coupled to hippocampal theta oscillations than adjacent spikes and, surprisingly, transiently express coherent representations of non-local spatial representations. Further, prefrontal cortical activity is coordinated with, and can predict the occurrence of future isolated spiking events. Rather than local noise within the hippocampus, sparse, isolated place cell spiking reflects a coordinated cortical-hippocampal process consistent with the generation of non-local scenario representations during active navigation.

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