scholarly journals Neuregulin-1-dependent control of amygdala microcircuits is critical for fear extinction

2021 ◽  
Vol 201 ◽  
pp. 108842
Author(s):  
Ming Chen ◽  
Ying Li ◽  
Ying Liu ◽  
Haibo Xu ◽  
Lin-Lin Bi
Keyword(s):  
Fear Extinction ◽  
Neuregulin 1

scholarly journals Neuregulin-1-dependent control of amygdala microcircuits is critical for fear extinction

2021 ◽  
Author(s):  
Ming Chen ◽  
Ying Liu ◽  
Ying Li ◽  
Haibo Xu ◽  
Linlin Bi
Keyword(s):  
Anxiety Disorders ◽  
Signaling Pathway ◽  
Stress Disorder ◽  
Fear Extinction ◽  
Excitatory Input ◽  
Gabaergic Neurotransmission ◽  
Neuregulin 1 ◽  
Impaired Ability ◽  
Underlying Mechanisms ◽  
Feed Forward Inhibition

Abstract Anxiety disorders, especially posttraumatic stress disorder, are marked by an impaired ability to understand that a conditioned stimulus previously paired with a noxious stimulus is no longer noxious. Although previous studies suggest that fear extinction depends on the function of the amygdala, the underlying mechanisms are unclear. We found that NRG1 receptors (ErbB4) were abundantly expressed in the intercalated amygdala (ITC). The NRG1-ErbB4 pathway in the ITC promotes fear extinction. The NRG1-ErbB4 pathway in the ITC did not affect excitatory input to ITC neurons from BLA neurons but increased feed-forward inhibition of CeM neurons through increased GABAergic neurotransmission of ITC neurons. We also found that the NRG1-ErbB4 signaling pathway in ITC might regulate fear extinction through P/Q-type voltage-activated Ca2+ channels (VACCs) but not through L- or N-type VACCs. Overall, our results suggest that the NRG1-ErbB4 signaling pathway in the ITC might represent a potential target for the treatment of anxiety disorders.

Myocardial Expression of Neuregulin-1 and Its Receptor ErbB4 in Patients with Chronic Heart Failure

2016 ◽  
Vol 64 (S 01) ◽  
Author(s):  
A. Beiras-Fernandez ◽  
J. Rothkopf ◽  
S. Kreth ◽  
A. Kornberger ◽  
U. Stock ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Neuregulin 1

Endothelial Derived Neuregulin-1 may be Important for Cardioprotection Induced by Ischemic Preconditioning

2017 ◽  
Vol 4 (5) ◽  
pp. 225-230
Author(s):  
Gui-Zhen Yang ◽  
Fu-Shan Xue ◽  
Chao Sun ◽  
Xu Liao ◽  
Jian-Hua Liu
Keyword(s):  
Ischemic Preconditioning ◽  
Neuregulin 1
Sign in / Sign up

Export Citation Format

Share Document