Increased polysialic acid neural cell adhesion molecule expression in human hippocampus of heroin addicts

Neuroscience ◽  
2006 ◽  
Vol 138 (4) ◽  
pp. 1215-1223 ◽  
Author(s):  
M. Weber ◽  
S. Modemann ◽  
P. Schipper ◽  
H. Trauer ◽  
H. Franke ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Heroin Addicts ◽  
Human Hippocampus ◽  
Neural Cell Adhesion

scholarly journals Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration.

1996 ◽  
Vol 135 (6) ◽  
pp. 1565-1581 ◽  
Author(s):  
C Wang ◽  
W F Pralong ◽  
M F Schulz ◽  
G Rougon ◽  
J M Aubry ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Adhesion ◽  
Nmda Receptor ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Neural Cell Adhesion

The capacity for long-distance migration of the oligodendrocyte precursor cell, oligodendrocyte-type 2 astrocyte (O-2A), is essential for myelin formation. To study the molecular mechanisms that control this process, we used an in vitro migration assay that uses neurohypophysial explants. We provide evidence that O-2A cells in these preparations express functional N-methyl-D-aspartate (NMDA) receptors, most likely as homomeric complexes of the NR1 subunit. We show that NMDA evokes an increase in cytosolic Ca2+ that can be blocked by the NMDA receptor antagonist AP-5 and by Mg2+. Blocking the activity of these receptors dramatically diminished O-2A cell migration from explants. We also show that NMDA receptor activity is necessary for the expression by O-2A cells of the highly sialylated polysialic acid-neural cell adhesion molecule (PSA-NCAM) that is required for their migration. Thus, glutamate or glutamate receptor ligands may regulate O-2A cell migration by modulating expression of PSA-NCAM. These studies demonstrate how interactions between ionotropic receptors, intracellular signaling, and cell adhesion molecule expression influence cell surface properties, which in turn are critical determinants of cell migration.

Expression of Neural Cell Adhesion Molecule and Polysialic Acid in Cultured Spiral Ganglion Neurons

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Kyoung Ho Park ◽  
Ki Hong Jang ◽  
Sang Yeo ◽  
Helge Rask-Andersen ◽  
Frederic Troy, II
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Spiral Ganglion ◽  
Neural Cell ◽  
Spiral Ganglion Neurons ◽  
Neural Cell Adhesion ◽  
Ganglion Neurons

Neural cell adhesion molecule expression in thyroid cancer

1996 ◽  
Author(s):  
Y Miyajima ◽  
S Ota ◽  
H Yasukawa ◽  
M Zenmyou ◽  
M Morimatsu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Neural Cell Adhesion

scholarly journals Role of Neural Cell Adhesion Molecule and Polysialic Acid in Mouse Circadian Clock Function

1997 ◽  
Vol 17 (13) ◽  
pp. 5221-5229 ◽  
Author(s):  
Huaming Shen ◽  
Michiko Watanabe ◽  
Henry Tomasiewicz ◽  
Urs Rutishauser ◽  
Terry Magnuson ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Circadian Clock ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Neural Cell ◽  
Neural Cell Adhesion
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