Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Neuroscience ◽

10.1016/j.neuroscience.2006.06.043 ◽

2006 ◽

Vol 142 (3) ◽

pp. 691-702 ◽

Author(s):

D. Balschun ◽

W. Zuschratter ◽

W. Wetzel

Keyword(s):

Spatial Memory ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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The Effects of MPEP, a Selective Metabotropic Glutamate Receptor 5 Antagonist, on Conditioned Taste Aversion in Rats

PsycEXTRA Dataset ◽

10.1037/e413812005-369 ◽

2002 ◽

Author(s):

Todd R. Schachtman ◽

Carla Bills ◽

Rodica Ghinescu ◽

Kevin Murch ◽

Agnes Simonyi

Keyword(s):

Taste Aversion ◽

Glutamate Receptor ◽

Conditioned Taste Aversion ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Faculty Opinions recommendation of Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718499023.793498248 ◽

2014 ◽

Author(s):

Roland Seifert

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Transmembrane Domain ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

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Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

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Downregulation of metabotropic glutamate receptor 5 alleviates central sensitization by activating autophagy via inhibiting mTOR pathway in a rat model of chronic migraine

Neuroscience Letters ◽

10.1016/j.neulet.2020.135552 ◽

2021 ◽

Vol 743 ◽

pp. 135552

Author(s):

Yingying Niu ◽

Xiaoxu Zeng ◽

Guangcheng Qin ◽

Dunke Zhang ◽

Jiying Zhou ◽

...

Keyword(s):

Chronic Migraine ◽

Glutamate Receptor ◽

Rat Model ◽

Central Sensitization ◽

Metabotropic Glutamate Receptor ◽

Mtor Pathway ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes

Neuroscience ◽

10.1016/j.neuroscience.2011.12.044 ◽

2012 ◽

Vol 205 ◽

pp. 29-38 ◽

Author(s):

J.V. Berger ◽

A.O. Dumont ◽

M.C. Focant ◽

M. Vergouts ◽

A. Sternotte ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 3 ◽

Inflammatory Stimuli

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Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus

Neuroscience ◽

10.1016/j.neuroscience.2010.06.023 ◽

2010 ◽

Vol 169 (4) ◽

pp. 1567-1574 ◽

Author(s):

A.H. Iyo ◽

A.M. Feyissa ◽

A. Chandran ◽

M.C. Austin ◽

S. Regunathan ◽

...

Keyword(s):

Protein Expression ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Rat Hippocampus ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats

Neuropharmacology ◽

10.1016/j.neuropharm.2011.08.028 ◽

2011 ◽

Vol 61 (8) ◽

pp. 1399-1405 ◽

Author(s):

Manoranjan S. D’Souza ◽

Athina Markou

Keyword(s):

Nucleus Accumbens ◽

Ventral Tegmental Area ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Nucleus Accumbens Shell ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Reinforcing Effects ◽

Ventral Tegmental

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Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1107304108 ◽

2011 ◽

Vol 108 (37) ◽

pp. 15219-15224 ◽

Author(s):

K. Y. Choi ◽

K. Chang ◽

J. M. Pickel ◽

J. D. Badger ◽

K. W. Roche

Keyword(s):

Transgenic Mice ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Identification of Specific Ligand–Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site

ACS Chemical Neuroscience ◽

10.1021/cn400225x ◽

2014 ◽

Vol 5 (4) ◽

pp. 282-295 ◽

Author(s):

Karen J. Gregory ◽

Elizabeth D. Nguyen ◽

Chrysa Malosh ◽

Jeffrey L. Mendenhall ◽

Jessica Z. Zic ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Site ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Receptor Interactions ◽

Specific Ligand

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Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators

Cell Chemical Biology ◽

10.1016/j.chembiol.2017.06.003 ◽

2017 ◽

Vol 24 (7) ◽

pp. 858-869.e5 ◽

Author(s):

Falgun Shah ◽

Antonia F. Stepan ◽

Alison O'Mahony ◽

Sharlene Velichko ◽

Alexandra E. Folias ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Skin Toxicity ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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