The Transient Receptor Potential Ankyrin Type 1 Plays a Critical Role in Cortical Spreading Depression

Neuroscience ◽  
2018 ◽  
Vol 382 ◽  
pp. 23-34 ◽  
Author(s):  
Liwen Jiang ◽  
Yan Wang ◽  
Yuewei Xu ◽  
Dongqing Ma ◽  
Minyan Wang
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Transient Receptor Potential ◽  
Critical Role ◽  
Receptor Potential ◽  
Transient Receptor

scholarly journals Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 669
Author(s):  
Francesca Maestrelli ◽  
Elisa Landucci ◽  
Enrico De Luca ◽  
Giulia Nerli ◽  
Maria Camilla Bergonzi ◽  
...  
Keyword(s):  
Neurogenic Inflammation ◽  
Transient Receptor Potential ◽  
Critical Role ◽  
Receptor Potential ◽  
Pain Sensation ◽  
Migraine Pain ◽  
The Central Nervous System ◽  
Transient Receptor ◽  
The Brain

The transient receptor potential akyrin type-1 (TRPA1) is a non-selective cation channel playing a pivotal role in pain sensation and neurogenic inflammation. TRPA1 channels expressed in the central nervous system (CNS) have a critical role in the modulation of cortical spreading depression (CSD), which is a key pathophysiological basis of migraine pain. ADM_09 is a recently developed lipoic acid-based TRPA1 antagonist that is able to revert oxaliplatin-induced neuropathic pain and inflammatory trigeminal allodynia. In this context, aiming at developing drugs that are able to target TRPA1 channels in the CNS and promote an antioxidant effect, permeability across the blood–brain barrier (BBB) represents a central issue. Niosomes are nanovesicles that can be functionalized with specific ligands selectively recognized by transporters expressed on the BBB. In this work, the activity of ADM_09 on neocortex cultures was studied, and an efficient formulation to cross the BBB was developed with the aim of increasing the concentration of ADM_09 into the brain and selectively delivering it to the CNS rapidly after parenteral administration.

scholarly journals Activation of Transient Receptor Potential Vanilloid Type-1 Channel Prevents Adipogenesis and Obesity

2007 ◽  
Vol 100 (7) ◽  
pp. 1063-1070 ◽  
Author(s):  
Li Li Zhang ◽  
Dao Yan Liu ◽  
Li Qun Ma ◽  
Zhi Dan Luo ◽  
Ting Bing Cao ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Transient Receptor

scholarly journals TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases

2015 ◽  
Vol 309 (5) ◽  
pp. F393-F397 ◽  
Author(s):  
Daria V. Ilatovskaya ◽  
Alexander Staruschenko
Keyword(s):  
Transient Receptor Potential ◽  
Calcium Influx ◽  
Kidney Diseases ◽  
Critical Role ◽  
Receptor Potential ◽  
Calcium Flux ◽  
Calcium Handling ◽  
Podocyte Injury ◽  
Trpc6 Channel ◽  
Transient Receptor

Podocytes (terminally differentiated epithelial cells of the glomeruli) play a key role in the maintenance of glomerular structure and permeability and in the incipiency of various renal abnormalities. Injury to podocytes is considered a major contributor to the development of kidney disease as their loss causes proteinuria and progressive glomerulosclerosis. The physiological function of podocytes is critically dependent on proper intracellular calcium handling; excessive calcium influx in these cells may result in the effacement of foot processes, apoptosis, and subsequent glomeruli damage. One of the key proteins responsible for calcium flux in the podocytes is transient receptor potential cation channel, subfamily C, member 6 (TRPC6); a gain-of-function mutation in TRPC6 has been associated with the onset of the familial forms of focal segmental glomerulosclerosis (FSGS). Recent data also revealed a critical role of this channel in the onset of diabetic nephropathy. Therefore, major efforts of the research community have been recently dedicated to unraveling the TRPC6-dependent effects in the initiation of podocyte injury. This mini-review focuses on the TRPC6 channel in podocytes and colligates recent data in an attempt to shed some light on the mechanisms underlying the pathogenesis of TRPC6-mediated glomeruli damage and its potential role as a therapeutic target for the treatment of chronic kidney diseases.

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