Participation of Glutamatergic Ionotropic Receptors in Excitotoxicity: The Neuroprotective Role of Prolactin

Pain originating in inflammation is the most common pathologic pain condition encountered by the anesthesiologist whether in the context of surgery, its aftermath, or in the practice of pain medicine. Inflammatory agents, released as components of the body's response to peripheral tissue damage or disease, are now known to be collectively capable of activating transient receptor potential vanilloid type 1, transient receptor potential vanilloid type 4, transient receptor potential ankyrin type 1, and acid-sensing ion channels, whereas individual agents may activate only certain of these ion channels. These ionotropic receptors serve many physiologic functions-as, indeed, do many of the inflammagens released in the inflammatory process. Here, we introduce the reader to the role of these ionotropic receptors in mediating peripheral pain in response to inflammation.

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The Role of Autoantibodies to the Extracellular Regions of Ionotropic Receptors in the Etiology and Pathogenesis of Autoimmune Diseases

Neuroscience and Behavioral Physiology ◽

10.1007/s11055-017-0523-y ◽

2017 ◽

Vol 48 (1) ◽

pp. 1-10

Author(s):

O. A. Zharova ◽

A. O. Shpakov

Keyword(s):

Autoimmune Diseases ◽

Ionotropic Receptors

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Ionotropic receptors in neuronal–astroglial signalling: What is the role of “excitable” molecules in non-excitable cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ◽

10.1016/j.bbamcr.2010.09.007 ◽

2011 ◽

Vol 1813 (5) ◽

pp. 992-1002 ◽

Cited By ~ 72

Author(s):

Ulyana Lalo ◽

Yuriy Pankratov ◽

Vladimir Parpura ◽

Alexei Verkhratsky

Keyword(s):

Excitable Cells ◽

Ionotropic Receptors

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Role of L-glutamate in aggression

Medycyna Weterynaryjna ◽

10.21521/mw.5603 ◽

2016 ◽

Vol 72 (12) ◽

pp. 740-744

Author(s):

Bogdan Feliks Kania ◽

Danuta Wrońska

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Steroid Receptors ◽

Cation Channels ◽

Metabotropic Receptor ◽

Ionotropic Receptors ◽

The Central Nervous System ◽

G Protein Coupled ◽

Stimulation Of

L-glutamate is one of major excitatory transmitters (along with aspartic, kainate acids and glycine) in the central nervous system and/or the peripheral nervous system. It mediates interaction through the stimulation of various ionotropic receptors families (ligand gated cation channels) and metabotropic receptor families (G-protein coupled). In this review, we describe the molecular composition of these glutamatergic receptors and discuss their neuropharmacology, particularly with respect to their roles in animal social behaviors and, particularly, in aggression. It is also known, that during aggression different interactions occur in the nervous system among glutamate, serotonin, vasopressin, oxytocin, dopamine, GABA and steroid receptors.

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