scholarly journals Putamen–midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases

2015 ◽  
Vol 8 ◽  
pp. 554-559 ◽  
Author(s):  
A. Rieckmann ◽  
S.N. Gomperts ◽  
K.A. Johnson ◽  
J.H. Growdon ◽  
K.R.A. Van Dijk
Keyword(s):  
Functional Connectivity ◽  
Dopamine Transporter ◽  
Lewy Body ◽  
Striatal Dopamine ◽  
Lewy Body Diseases

Discriminating atypical Parkinsonian syndromes from lewy body diseases using striatal dopamine transporter activity and regional perfusion images

2017 ◽  
Vol 381 ◽  
pp. 125-126
Author(s):  
S. Takaya ◽  
N. Sawamoto ◽  
T. Okada ◽  
G. Okubo ◽  
S. Nishida ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Lewy Body ◽  
Regional Perfusion ◽  
Striatal Dopamine ◽  
Parkinsonian Syndromes ◽  
Lewy Body Diseases

scholarly journals Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging

2018 ◽  
Vol 115 (40) ◽  
pp. 10160-10165 ◽  
Author(s):  
Anna Rieckmann ◽  
Keith A. Johnson ◽  
Reisa A. Sperling ◽  
Randy L. Buckner ◽  
Trey Hedden
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Dopamine Transporter ◽  
Normal Aging ◽  
Striatal Dopamine ◽  
Functional Coupling ◽  
Younger Adults ◽  
Memory Decline ◽  
Age Related ◽  
Striatal Function

Age-related changes in striatal function are potentially important for predicting declining memory performance over the adult life span. Here, we used fMRI to measure functional connectivity of caudate subfields with large-scale association networks and positron emission tomography to measure striatal dopamine transporter (DAT) density in 51 older adults (age 65–86 years) who received annual cognitive testing for up to 7 years (mean = 5.59, range 2–7 years). Analyses showed that cortical–caudate functional connectivity was less differentiated in older compared with younger adults (n= 63, age 18–32 years). Unlike in younger adults, the central lateral caudate was less strongly coupled with the frontal parietal control network in older adults. Older adults also showed less “decoupling” of the caudate from other networks, including areas of the default network (DN) and the hippocampal complex. Contrary to expectations, less decoupling between caudate and the DN was not associated with an age-related reduction of striatal DAT, suggesting that neurobiological changes in the cortex may drive dedifferentiation of cortical–caudate connectivity. Reduction of specificity in functional coupling between caudate and regions of the DN predicted memory decline over subsequent years at older ages. The age-related reduction in striatal DAT density also predicted memory decline, suggesting that a relation between striatal functions and memory decline in aging is multifaceted. Collectively, the study provides evidence highlighting the association of age-related differences in striatal function to memory decline in normal aging.

'Sick But Not Dead': Multiple Denervation-Independent Abnormalities of Myocardial Noradrenergic Function in Lewy Body Diseases

2019 ◽  
Author(s):  
David S. Goldstein ◽  
Mark Pekker ◽  
Graeme Eisenhofer ◽  
Yehonatan Sharabi
Keyword(s):  
Lewy Body ◽  
Noradrenergic Function ◽  
Lewy Body Diseases

Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer’s disease

2021 ◽  
Author(s):  
David G. Coughlin ◽  
Murray Grossman ◽  
John Q. Trojanowski ◽  
David J. Irwin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Diseases

P.6.083 Enhanced striatal dopamine transporter activity in drug naive and previously treated patients with gilles de la tourette syndrome (GTS): A [123l]-β-CIT SPECT-study

1997 ◽  
Vol 7 ◽  
pp. S289-S290
Author(s):  
M. Stamenkovic ◽  
S.D. Schindler ◽  
S. Asenbaum ◽  
Th. Brücke ◽  
H.N. Aschauer ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Tourette Syndrome ◽  
Striatal Dopamine ◽  
Previously Treated Patients ◽  
Previously Treated ◽  
Drug Naïve

scholarly journals Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases

2021 ◽  
Author(s):  
Rahel Feleke ◽  
Regina H. Reynolds ◽  
Amy M. Smith ◽  
Bension Tilley ◽  
Sarah A. Gagliano Taliun ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Lewy Body ◽  
Molecular Mechanisms ◽  
Lewy Bodies ◽  
Subsequent Development ◽  
Lewy Body Dementia ◽  
Anterior Cingulate ◽  
Lewy Body Diseases

AbstractParkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping neurodegenerative diseases collectively known as the Lewy body diseases (LBDs). A variety of molecular mechanisms have been implicated in PD pathogenesis, but the mechanisms underlying PDD and DLB remain largely unknown, a knowledge gap that presents an impediment to the discovery of disease-modifying therapies. Transcriptomic profiling can contribute to addressing this gap, but remains limited in the LBDs. Here, we applied paired bulk-tissue and single-nucleus RNA-sequencing to anterior cingulate cortex samples derived from 28 individuals, including healthy controls, PD, PDD and DLB cases (n = 7 per group), to transcriptomically profile the LBDs. Using this approach, we (i) found transcriptional alterations in multiple cell types across the LBDs; (ii) discovered evidence for widespread dysregulation of RNA splicing, particularly in PDD and DLB; (iii) identified potential splicing factors, with links to other dementia-related neurodegenerative diseases, coordinating this dysregulation; and (iv) identified transcriptomic commonalities and distinctions between the LBDs that inform understanding of the relationships between these three clinical disorders. Together, these findings have important implications for the design of RNA-targeted therapies for these diseases and highlight a potential molecular “window” of therapeutic opportunity between the initial onset of PD and subsequent development of Lewy body dementia.

scholarly journals Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease

2021 ◽  
pp. 1-6
Author(s):  
Julia Schumacher ◽  
Alan J. Thomas ◽  
Luis R. Peraza ◽  
Michael Firbank ◽  
John T. O’Brien ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Lewy Body ◽  
Cholinergic System ◽  
Structural Changes ◽  
Lewy Body Dementia ◽  
Occipital Cortex ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

ABSTRACT Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.

scholarly journals The spectrum of cognitive impairment in Lewy body diseases

2014 ◽  
Vol 29 (5) ◽  
pp. 608-621 ◽  
Author(s):  
Jennifer G. Goldman ◽  
Caroline Williams-Gray ◽  
Roger A. Barker ◽  
John E. Duda ◽  
James E. Galvin
Keyword(s):  
Cognitive Impairment ◽  
Lewy Body ◽  
Lewy Body Diseases
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