Mapping acute lesion locations to physiological swallow impairments after stroke

У статті описано клінічний випадок рідкісного пошкодження – травматичного відшарування шкіри (ТВШ) у дитини внаслідок травмування колінного суглоба. Згідно з даними літератури, відшарування шкіри (small acute lesion) спостерігають при наїзді колеса автомобіля на ногу, падінні з висоти, ударі важким предметом, стисненні між автомобілями, тачками, вагонетками, волочінні тіла по землі – це основні фактори, які сприяють ТВШ. Незважаючи на те, що дане пошкодження давно (у 1848 р.) описав французький хірург Morel-Lavallet, дотепер його вивчено недостатньо. Тому хірурги і травматологи не завжди вчасно можуть діагностувати таке пошкодження, що обумовлює несвоєчасну та неадекватну терапію. Травми колінного суглоба в дітей з гематомами будь-якої локалізації, резистентними до консервативного лікування, необхідно розглядати як серйозні пошкодження з метою діагностики ТВШ, використовуючи такі сучасні методи обстеження, як УЗД, МРТ.

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The acute lesion

Tetraplegia and Paraplegia ◽

10.1016/b978-044310180-9.50006-1 ◽

2006 ◽

pp. 41-52

Keyword(s):

Acute Lesion

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SLAP Lesions Part II: Acute Lesion Versus Chronic Lesion Resulting from Repetitive Motion (or Microtrauma)

Sports Injuries to the Shoulder and Elbow ◽

10.1007/978-3-642-41795-5_11 ◽

2015 ◽

pp. 109-116

Author(s):

Lennard Funk ◽

Puneet Monga

Keyword(s):

Repetitive Motion ◽

Slap Lesions ◽

Acute Lesion

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MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury

Spinal Cord ◽

10.1038/sc.2013.99 ◽

2013 ◽

Vol 51 (11) ◽

pp. 823-827 ◽

Cited By ~ 20

Author(s):

J M Simard ◽

P G Popovich ◽

O Tsymbalyuk ◽

J Caridi ◽

R P Gullapalli ◽

...

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Rat Model ◽

Acute Lesion ◽

Cord Injury

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AN INFECTIOUS GRANULAR VAGINITIS OF COWS

Journal of Experimental Medicine ◽

10.1084/jem.45.3.519 ◽

1927 ◽

Vol 45 (3) ◽

pp. 519-528 ◽

Cited By ~ 4

Author(s):

F. S. Jones ◽

Ralph B. Little

Keyword(s):

Acute Inflammation ◽

Vaginal Mucosa ◽

Epithelial Layer ◽

Gram Negative ◽

Defibrinated Horse Blood ◽

Negative Bacillus ◽

Acute Lesion ◽

Polar Granules ◽

Gram Negative Bacillus ◽

Horse Blood

A disease of cows characterized by swelling of the vulva, acute inflammation of the vaginal mucosa, accompanied by a more or less profuse mucopurulent exudate is described. After the acute inflammation subsides the mucosa becomes studded with tiny, round, raised, red nodules which persist 2 or 3 months or longer. The acute lesion consists in necrosis of the epithelium and accumulations of leucocytes and round cells in the edematous submucosa. The nodules in the later stages are made up of densely packed masses of lymphocytes in the submucosa which force the epithelial layer outward. A Gram-negative bacillus with tiny polar granules was found in the exudate. It measures I to 2µ in length and stains with difficulty. The organism was obtained in pure culture by inoculating the exudate into tubes of slanted agar to which defibrinated horse blood had been added. Growth occurs only in sealed tubes. The organism possesses slight pathogenicity for guinea pigs. When freshly isolated cultures were introduced into the vagina of heifers or young calves, acute inflammation resulted which terminated in the characteristic granular stage of the disease.

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Age in the system of pathokinetic factors of insult

Neurology Bulletin ◽

10.17816/nb80119 ◽

1997 ◽

Vol XXIX (3-4) ◽

pp. 9-12

Author(s):

B. S. Vilensky ◽

Т. V, Grinevich ◽

G. M. Semjonova ◽

I. V. Semjonova ◽

Е. D. Smirnova

Keyword(s):

Subarachnoid Hemorrhage ◽

Cerebral Circulation ◽

The Body ◽

Acute Lesion ◽

Sex Type ◽

Different Ages

Pathokinesis of ischemic and hemorrhagic insult, of subarachnoid hemorrhage has been analyzed on the basis of data of 211 patients and analysis of 282 autopsy protocols for people, dying from the same forms of acute lesion of cerebral circulation. It was stated that the age itself does not determine the course and outcome of insult, being only the background for revealing other, not less important factors: sex, type, severity and insult complications, degree of homeostatic disorganization. At different ages compensatory reserves of the body are being realized not synonymously, resulting in the determination of social-and-life-rehabilitation level.

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In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET

Journal of Cerebral Blood Flow & Metabolism ◽

10.1177/0271678x20931140 ◽

2020 ◽

pp. 0271678X2093114 ◽

Cited By ~ 2

Author(s):

Majken B Thomsen ◽

Jan Jacobsen ◽

Thea P Lillethorup ◽

Anna C Schacht ◽

Mette Simonsen ◽

...

Keyword(s):

Transmembrane Protein ◽

Regional Distribution ◽

High Dose ◽

Neuroprotective Agents ◽

Arterial Blood ◽

Acute Lesion ◽

Protein Density ◽

6 Hydroxydopamine ◽

Synaptic Responses

The number of functionally active synapses provides a measure of neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembrane protein located in secretory vesicles. We aimed to assess [11C]UCB-J PET as an in vivo biomarker of regional cerebral synaptic SV2A density in rat lesion models of neurodegeneration. Healthy anesthetized rats had [11C]UCB-J PET and arterial blood sampling. We compared different models describing [11C]UCB-J brain uptake kinetics to determine its regional distribution. Blocking studies were performed with levetiracetam (LEV), an antiepileptic SV2A antagonist. Tracer binding was measured in rodent unilateral acute lesion models of Parkinsonism and Huntington’s disease, induced with 6-hydroxydopamine (6-OHDA) and quinolinic acid (QA), respectively. [3H]UCB-J autoradiography was performed in postmortem tissue. Rat brain showed high and fast [11C]UCB-J uptake and washout with up to 80% blockade by LEV. [11C]UCB-J PET showed a 6.2% decrease in ipsilateral striatal SV2A binding after 6-OHDA and 39.3% and 55.1% decreases after moderate and high dose QA confirmed by autoradiography. In conclusion, [11C]UCB-J PET provides a good in vivo marker of synaptic SV2A density which can potentially be followed longitudinally along with synaptic responses to putative neuroprotective agents in models of neurodegeneration.

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