scholarly journals КЛІНІЧНИЙ ВИПАДОК ПОШКОДЖЕННЯ МОРЕЛЬ-ЛАВАЛЛЕ В ДИТИНИ

2019 ◽  
pp. 24-25
Author(s):  
M. D. Protsaylo
Keyword(s):  
Acute Lesion

У статті описано клінічний випадок рідкісного пошкодження – травматичного відшарування шкіри (ТВШ) у дитини внаслідок травмування колінного суглоба. Згідно з даними літератури, відшарування шкіри (small acute lesion) спостерігають при наїзді колеса автомобіля на ногу, падінні з висоти, ударі важким предметом, стисненні між автомобілями, тачками, вагонетками, волочінні тіла по землі – це основні фактори, які сприяють ТВШ. Незважаючи на те, що дане пошкодження давно (у 1848 р.) описав французький хірург Morel-Lavallet, дотепер його вивчено недостатньо. Тому хірурги і травматологи не завжди вчасно можуть діагностувати таке пошкодження, що обумовлює несвоєчасну та неадекватну терапію. Травми колінного суглоба в дітей з гематомами будь-якої локалізації, резистентними до консервативного лікування, необхідно розглядати як серйозні пошкодження з метою діагностики ТВШ, використовуючи такі сучасні методи обстеження, як УЗД, МРТ.

scholarly journals Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional Outcomes

Stroke ◽  
2015 ◽  
Vol 46 (9) ◽  
pp. 2438-2444 ◽  
Author(s):  
Ona Wu ◽  
Lisa Cloonan ◽  
Steven J.T. Mocking ◽  
Mark J.R.J. Bouts ◽  
William A. Copen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Outcomes ◽  
Stroke Severity ◽  
Acute Lesion ◽  
Lesion Topography

scholarly journals MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury

Spinal Cord ◽  
2013 ◽  
Vol 51 (11) ◽  
pp. 823-827 ◽  
Author(s):  
J M Simard ◽  
P G Popovich ◽  
O Tsymbalyuk ◽  
J Caridi ◽  
R P Gullapalli ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Acute Lesion ◽  
Cord Injury

scholarly journals AN INFECTIOUS GRANULAR VAGINITIS OF COWS

1927 ◽  
Vol 45 (3) ◽  
pp. 519-528 ◽  
Author(s):  
F. S. Jones ◽  
Ralph B. Little
Keyword(s):  
Acute Inflammation ◽  
Vaginal Mucosa ◽  
Epithelial Layer ◽  
Gram Negative ◽  
Defibrinated Horse Blood ◽  
Negative Bacillus ◽  
Acute Lesion ◽  
Polar Granules ◽  
Gram Negative Bacillus ◽  
Horse Blood

A disease of cows characterized by swelling of the vulva, acute inflammation of the vaginal mucosa, accompanied by a more or less profuse mucopurulent exudate is described. After the acute inflammation subsides the mucosa becomes studded with tiny, round, raised, red nodules which persist 2 or 3 months or longer. The acute lesion consists in necrosis of the epithelium and accumulations of leucocytes and round cells in the edematous submucosa. The nodules in the later stages are made up of densely packed masses of lymphocytes in the submucosa which force the epithelial layer outward. A Gram-negative bacillus with tiny polar granules was found in the exudate. It measures I to 2µ in length and stains with difficulty. The organism was obtained in pure culture by inoculating the exudate into tubes of slanted agar to which defibrinated horse blood had been added. Growth occurs only in sealed tubes. The organism possesses slight pathogenicity for guinea pigs. When freshly isolated cultures were introduced into the vagina of heifers or young calves, acute inflammation resulted which terminated in the characteristic granular stage of the disease.

scholarly journals Age in the system of pathokinetic factors of insult

1997 ◽  
Vol XXIX (3-4) ◽  
pp. 9-12
Author(s):  
B. S. Vilensky ◽  
Т. V, Grinevich ◽  
G. M. Semjonova ◽  
I. V. Semjonova ◽  
Е. D. Smirnova
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Circulation ◽  
The Body ◽  
Acute Lesion ◽  
Sex Type ◽  
Different Ages

Pathokinesis of ischemic and hemorrhagic insult, of subarachnoid hemorrhage has been analyzed on the basis of data of 211 patients and analysis of 282 autopsy protocols for people, dying from the same forms of acute lesion of cerebral circulation. It was stated that the age itself does not determine the course and outcome of insult, being only the background for revealing other, not less important factors: sex, type, severity and insult complications, degree of homeostatic disorganization. At different ages compensatory reserves of the body are being realized not synonymously, resulting in the determination of social-and-life-rehabilitation level.

scholarly journals In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET

2020 ◽  
pp. 0271678X2093114 ◽  
Author(s):  
Majken B Thomsen ◽  
Jan Jacobsen ◽  
Thea P Lillethorup ◽  
Anna C Schacht ◽  
Mette Simonsen ◽  
...  
Keyword(s):  
Transmembrane Protein ◽  
Regional Distribution ◽  
High Dose ◽  
Neuroprotective Agents ◽  
Arterial Blood ◽  
Acute Lesion ◽  
Protein Density ◽  
6 Hydroxydopamine ◽  
Synaptic Responses

The number of functionally active synapses provides a measure of neural integrity, with reductions observed in neurodegenerative disorders. [11C]UCB-J binds to synaptic vesicle 2A (SV2A) transmembrane protein located in secretory vesicles. We aimed to assess [11C]UCB-J PET as an in vivo biomarker of regional cerebral synaptic SV2A density in rat lesion models of neurodegeneration. Healthy anesthetized rats had [11C]UCB-J PET and arterial blood sampling. We compared different models describing [11C]UCB-J brain uptake kinetics to determine its regional distribution. Blocking studies were performed with levetiracetam (LEV), an antiepileptic SV2A antagonist. Tracer binding was measured in rodent unilateral acute lesion models of Parkinsonism and Huntington’s disease, induced with 6-hydroxydopamine (6-OHDA) and quinolinic acid (QA), respectively. [3H]UCB-J autoradiography was performed in postmortem tissue. Rat brain showed high and fast [11C]UCB-J uptake and washout with up to 80% blockade by LEV. [11C]UCB-J PET showed a 6.2% decrease in ipsilateral striatal SV2A binding after 6-OHDA and 39.3% and 55.1% decreases after moderate and high dose QA confirmed by autoradiography. In conclusion, [11C]UCB-J PET provides a good in vivo marker of synaptic SV2A density which can potentially be followed longitudinally along with synaptic responses to putative neuroprotective agents in models of neurodegeneration.

scholarly journals Remotely Navigated Ablations in Ventricle Myocardium Result in Acute Lesion Size Comparable to Force-Sensing Manual Navigation

2019 ◽  
Vol 12 (10) ◽  
Author(s):  
Jiří Jež ◽  
Guido Caluori ◽  
Tomasz Jadczyk ◽  
František Lehar ◽  
Martin Pešl ◽  
...  
Keyword(s):  
Lesion Size ◽  
Force Sensing ◽  
Acute Lesion

Abstract 40: The Disappearing Core: Time to Re-think Irreversible Injury in This Era of Endovascular Therapy

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Amie W Hsia ◽  
Marie Luby ◽  
Rocco Armonda ◽  
Ai-hsi Liu ◽  
Richard T Benson ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Endovascular Therapy ◽  
Good Clinical Outcome ◽  
New Era ◽  
Neurological Improvement ◽  
Acute Lesion ◽  
Ischemic Core ◽  
Irreversible Injury ◽  
Iv Tpa

Background and Purpose: Early and complete recanalization achieved in this new era of endovascular therapy (ET) can result in nearly imperceptible lesions on post-treatment MRI. In this context we have observed a pattern of lesion evolution on MRI that is atypical from that seen following IV tPA alone, including striking reversal of the ischemic core. We sought to determine the frequency of acute lesion reversal following ET, and its association with sustained reversal and clinical outcome. Methods: Patients were included in this study if: 1) ET for anterior territory ischemic stroke from Jan 2015 to July 2016, 2) baseline pre-ET and 24h MRI, and 3) consent for research. Two raters evaluated ADC maps for early “reversal” (defined visually as >50%) by comparing 24h to baseline. FLAIR MRI at 30d were later assessed for reversal from baseline, blinded to 24h scan. Early neurological improvement (ENI) was defined as decrease in NIHSS≥8 at 24h. Good clinical outcome defined as mRS≤2. Results: Twenty-two patients were included: median age 68.5 years, 73% women, median baseline NIHSS 19. Median time from last known well to recanalization 254 min. TICI 2b/3 in 91%. ADC reversal in 12 of 22 (55%) at 24h. Reversal at 30d was associated with 24hr (p=0.002) with two having no visually appreciable infarct at 30d. Baseline NIHSS did not differ for early reversal versus without (18.5 vs. 19.5), however NIHSS differed at discharge (1.5 vs. 8.5, p=0.003); early reversal is significantly associated with ENI (83% vs. 30%, p=0.027), but not with good clinical outcome at 30-90d (50% vs. 30%, p=0.415). Conclusions: In this new era of consistently effective ET, salvageable tissue includes not just penumbra but ischemic core, previously considered irreversibly injured. Despite lesion reversal and ENI, for some patients, independent outcome is not achieved, a finding that reinforces the need for adjunctive treatments to build upon the success of ET. Figure: Example of a patient with early ADC reversal.

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