Distinct ventral and dorsal hippocampus AP5 anxiolytic effects revealed in the elevated plus-maze task in rats

In phytotherapy, the essential oil from the leaves of Alpinia zerumbet ( Alpinia speciosa K. Schum.) (EOAZ) is used for neuropsychiatric symptoms, such as depression, stress and anxiety, and chronic problems that are associated with reproductive hormone imbalances in women. The chemical composition of EOAZ was analyzed by GC/MS, and the EOAZ properties inducing behavioral alterations in mice were examined by behavioral observations (BO) and an elevated plus-maze task (EPM), widely used as a method for assessing anxiolytic-like behaviors. Five major compounds, p-cymene (28.0 ± 5.0%), 1,8-cineole (17.9 ± 4.2%), terpinen-4-ol (11.9 ± 6.3%), limonene (6.3 ± 2.2%), and camphor (5.2 ± 2.1%) were identified by retention indices, mass spectra and comparison with standards. Inhalational administration of EOAZ (8.7 ppm) induced unique jumping behaviors in mice. To further investigate the behavioral regulatory mechanisms of EOAZ, we administered an intraperitoneal injection of either 10 mg/kg 5-HTP or 10 mg/kg fluoxetine prior to the EOAZ inhalations. By 5-HTP or fluoxetine pretreatments, the jumping frequencies were significantly decreased. In EPM, EOAZ (0.087 and 8.7 ppm) obviously showed the anxiolytic-like activity in mice.

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Effects of glycine or (±)-3-amino-l-hydroxy-2-pyrrolidone microinjections along the rostrocaudal axis of the dorsal periaqueductal gray matter on rats' performance in the elevated plus-maze task.

Behavioral Neuroscience ◽

10.1037/0735-7044.113.1.196 ◽

1999 ◽

Vol 113 (1) ◽

pp. 196-203 ◽

Cited By ~ 23

Author(s):

Karina V. Teixeira ◽

Antonio P. Carobrez

Keyword(s):

Gray Matter ◽

Elevated Plus Maze ◽

Periaqueductal Gray ◽

Maze Task ◽

Periaqueductal Gray Matter ◽

Dorsal Periaqueductal Gray ◽

Plus Maze ◽

Rostrocaudal Axis

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Agmatine induces anxiolysis in the elevated plus maze task in adult rats

Behavioural Brain Research ◽

10.1016/s0166-4328(02)00326-1 ◽

2003 ◽

Vol 141 (1) ◽

pp. 19-24 ◽

Cited By ~ 57

Author(s):

Daniel Lavinsky ◽

Nice Sarmento Arteni ◽

Carlos Alexandre Netto

Keyword(s):

Elevated Plus Maze ◽

Maze Task ◽

Adult Rats ◽

Plus Maze

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Changes in the biogenic amine content of the prefrontal cortex, amygdala, dorsal hippocampus, and nucleus accumbens of rats submitted to single and repeated sessions of the elevated plus-maze test

Brazilian Journal of Medical and Biological Research ◽

10.1590/s0100-879x2005001200014 ◽

2005 ◽

Vol 38 (12) ◽

pp. 1857-1866 ◽

Cited By ~ 28

Author(s):

M.C. Carvalho ◽

L. Albrechet-Souza ◽

S. Masson ◽

M.L. Brandão

Keyword(s):

Prefrontal Cortex ◽

Nucleus Accumbens ◽

Biogenic Amine ◽

Elevated Plus Maze ◽

Dorsal Hippocampus ◽

Elevated Plus Maze Test ◽

Maze Test ◽

Amine Content ◽

Plus Maze

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Effects of NOS inhibitors on the benzodiazepines-induced memory impairment of mice in the modified elevated plus-maze task

Behavioural Brain Research ◽

10.1016/j.bbr.2013.01.038 ◽

2013 ◽

Vol 244 ◽

pp. 100-106 ◽

Cited By ~ 11

Author(s):

Jolanta Orzelska ◽

Sylwia Talarek ◽

Joanna Listos ◽

Sylwia Fidecka

Keyword(s):

Memory Impairment ◽

Elevated Plus Maze ◽

Maze Task ◽

Plus Maze ◽

Nos Inhibitors

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Behavioral Changes Induced by Angiotensin AT1 Receptors Blockade in the Rat Brain

European Psychiatry ◽

10.1016/s0924-9338(09)71092-2 ◽

2009 ◽

Vol 24 (S1) ◽

pp. 1-1 ◽

Cited By ~ 2

Author(s):

L. Hritcu ◽

W. Bild ◽

A. Ciobica ◽

V. Artenie ◽

I. Haulica

Keyword(s):

Angiotensin Ii ◽

Elevated Plus Maze ◽

Anxiety State ◽

Avoidance Task ◽

Maze Task ◽

Term Memory ◽

Y Maze ◽

Plus Maze ◽

The Brain

Aims:The brain renin-angiotensin system is involved in learning and memory, but the actual role of angiotensin II and its metabolites in this process has been difficult to comprehend. In the present study we assessed the role of the angiotensin AT1 receptors in certain behavioral effects of angiotensin II using their selective antagonist losartan and PD123319, intracerebroventricularly (icv) administrated.Methods:Male Wistar rats were divided into three groups: 1. sham-operated; 2. Losartan; 3. PD123319. All drugs were stereotaxically icv injected. Learning and memory tests began 2 weeks after the operation, and the ability of the rats to acquire the operant task was studied by means of Y-maze task and passive avoidance task, respectively. The anxiety state was measured in elevated plus maze.Results:Losartan and PD123319 significantly impaired spatial memory in Y-maze task, suggesting significant effects on short-term memory. In passive avoidance task, both angiotensin II antagonist, significantly decreased step-through-latency, suggesting significant effects on long-term memory. In elevated plus maze measuring anxiety, both drugs diminished anxiety state.Conclusions:Our results suggest the considerable involvement of the brain ATi angiotensin receptors in the cognition improving effects of angiotensin.

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