scholarly journals Female mice with apolipoprotein E4 domain interaction demonstrated impairments in spatial learning and memory performance and disruption of hippocampal cyto-architecture

2019 ◽  
Vol 161 ◽  
pp. 106-114 ◽  
Author(s):  
Samuel O. Adeosun ◽  
Xu Hou ◽  
Lili Shi ◽  
Craig A. Stockmeier ◽  
Baoying Zheng ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Performance ◽  
Spatial Learning And Memory ◽  
Domain Interaction ◽  
Female Mice ◽  
Apolipoprotein E4

Deficits in Spatial Learning and Memory is Associated with Hippocampal Volume Loss in Aged Apolipoprotein E4 Mice

2011 ◽  
Vol 27 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Jun-xiang Yin ◽  
Gregory H. Turner ◽  
Hao-jie Lin ◽  
Stephen W. Coons ◽  
Jiong Shi
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Hippocampal Volume ◽  
Spatial Learning And Memory ◽  
Volume Loss ◽  
Apolipoprotein E4

scholarly journals Individual difference in prepulse inhibition does not predict spatial learning and memory performance in C57BL/6 mice

2015 ◽  
Vol 15 (4) ◽  
pp. 878-888 ◽  
Author(s):  
Daria Peleg-Raibstein ◽  
Singer Philipp ◽  
Joram Feldon ◽  
Benjamin K. Yee
Keyword(s):  
Learning And Memory ◽  
Individual Difference ◽  
Prepulse Inhibition ◽  
Spatial Learning ◽  
Memory Performance ◽  
Spatial Learning And Memory

scholarly journals Naloxone Ameliorates Spatial Memory Deficits and Hyperthermia Induced by a Neurotoxic Methamphetamine Regimen in Male Rats

2019 ◽  
Vol 8 ◽  
pp. 1182 ◽  
Author(s):  
Solmaz Khalifeh ◽  
Mehdi Khodamoradi ◽  
Vahid Hajali ◽  
Hamed Ghazvini ◽  
Lelia Eliasy ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Spatial Memory ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Memory Performance ◽  
Poor Performance ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Opiate Antagonist

Background: Methamphetamine (METH) as a synthetic psychostimulant is being increasingly recognized as a worldwide problem, which may induce memory impairment. On the other hand, it is well established that naloxone, an opiate antagonist, has some beneficial effects on learning and memory. The present research aimed at evaluating naloxone effects on spatial learning and memory impairment triggered by a neurotoxic regimen of METH in male rats. Materials and Methods: The animals received the subcutaneous (sc) regimen of METH (4×6 mg/kg at 2-h intervals), intraperitoneal (ip) naloxone (4×1 mg/kg at 2-h intervals), or normal saline at four events. The Nal-METH group of rats received four naloxone injections (1 mg/kg, ip) 30 min before each METH injection (6 mg/kg, sc) at 2-h intervals. Seven days later, they were evaluated for spatial learning and memory in the Morris Water Maze (MWM) task. Result: METH regimen induced hyperthermia, as well as a poor performance, in the acquisition and retention phases of the task, indicating spatial learning and memory impairment compared to the controls. Naloxone administration (1 mg/kg, ip) before each METH injection led to significant attenuations of both hyperthermia and METH adverse effects on the rat performance in the MWM task. Conclusion: The results revealed that pretreatment with the opiate antagonist naloxone could prevent METH adverse effects on body temperature and memory performance. It seems that the opioidergic system and hyperthermia may, at least partially, be involved in METH effects on spatial memory. [GMJ. 2019;8:e1182]

scholarly journals Influences of two different training paradigms on spatial learning and memory performance of hippocampal injured rats

2013 ◽  
Vol 33 (2) ◽  
pp. 237-240
Author(s):  
Hui BIAN ◽  
Song FANG ◽  
Ying-Da MIAO ◽  
Hua-Lin YU
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Performance ◽  
Spatial Learning And Memory

Regular treadmill running improves spatial learning and memory performance in young mice through increased hippocampal neurogenesis and decreased stress

2013 ◽  
Vol 1531 ◽  
pp. 1-8 ◽  
Author(s):  
Hongwei Li ◽  
Aming Liang ◽  
Fangxia Guan ◽  
Ruitai Fan ◽  
Liankai Chi ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Performance ◽  
Hippocampal Neurogenesis ◽  
Treadmill Running ◽  
Spatial Learning And Memory ◽  
Young Mice

scholarly journals Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice

2021 ◽  
Author(s):  
Cellas A Hayes ◽  
Erik L Hodges ◽  
Jessica P Marshall ◽  
Sreemathi Logan ◽  
Julie A Farley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Hippocampal Neurons ◽  
Spatial Learning And Memory ◽  
Insulin Like Growth Factor ◽  
Male Mice ◽  
Female Mice ◽  
Learning Impairments ◽  
Increased Risk

Reductions in insulin-like growth factor-1 (IGF-1) are associated with cognitive impairment and increased risk of neurodegenerative disease in advanced age. In mouse models, reduced IGF-1 early-in-life leads to memory impairments and synaptic dysfunction; however, these models are limited by systemic reductions in IGF-1. We hypothesized that IGF-1 continues to promote hippocampal neuron structure and function after development, and as such, the loss of IGF-1 signaling in adult neurons would lead to impaired spatial learning and memory. To test this, the IGF-1 receptor (IGF-1R) was genetically targeted in hippocampal neurons of adult male and female mice. Male mice deficient in neuronal IGF-1R exhibited spatial learning impairments as evidenced by increased pathlength and errors in the radial arm water maze. No differences in learning and memory were observed in female mice. Golgi-Cox staining revealed a reduced number of dendritic boutons of neurons the CA1 region of the hippocampus in male mice. Decreased MAPK and increased ROCK activity were also observed in these tissues. In vitro studies revealed that impaired neurite outgrowth due to inhibited IGF-1R signaling could be rescued by pharmacological inhibitors of ROCK. However, ROCK inhibition in neuronal IGF-1R deficient mice did not fully rescue learning impairments or bouton numbers. Together, our study highlights that IGF-1 continues to support spatial learning and memory and neuronal structure in adulthood.

scholarly journals Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse

2021 ◽  
Vol 2 ◽  
Author(s):  
Alina C. Stimmell ◽  
Zishen Xu ◽  
Shawn C. Moseley ◽  
Sarah D. Benthem ◽  
Diana M. Fernandez ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Performance ◽  
Brain Network ◽  
Spatial Learning And Memory ◽  
Tau Pathology ◽  
Spatial Disorientation ◽  
Spatial Reorientation ◽  
Hippocampal Network ◽  
The Relationship

In early Alzheimer's disease (AD) spatial navigation is one of the first impairments to emerge; however, the precise cause of this impairment is unclear. Previously, we showed that, in a mouse model of tau and amyloid beta (Aβ) aggregation, getting lost represents, at least in part, a failure to use distal cues to get oriented in space and that impaired parietal-hippocampal network level plasticity during sleep may underlie this spatial disorientation. However, the relationship between tau and amyloid beta aggregation in this brain network and impaired spatial orientation has not been assessed. Therefore, we used several approaches, including canonical correlation analysis and independent components analysis tools, to examine the relationship between pathology profile across the parietal-hippocampal brain network and spatial reorientation learning and memory performance. We found that consistent with the exclusive impairment in 3xTg-AD 6-month female mice, only 6-month female mice had an ICA identified pattern of tau pathology across the parietal-hippocampal network that were positively correlated with behavior. Specifically, a higher density of pTau positive cells predicted worse spatial learning and memory. Surprisingly, despite a lack of impairment relative to controls, 3-month female, as well as 6- and 12- month male mice all had patterns of tau pathology across the parietal-hippocampal brain network that are predictive of spatial learning and memory performance. However, the direction of the effect was opposite, a negative correlation, meaning that a higher density of pTau positive cells predicted better performance. Finally, there were not significant group or region differences in M78 density at any of the ages examined and ICA analyses were not able to identify any patterns of 6E10 staining across brain regions that were significant predictors of behavioral performance. Thus, the pattern of pTau staining across the parietal-hippocampal network is a strong predictor of spatial learning and memory performance, even for mice with low levels of tau accumulation and intact spatial re-orientation learning and memory. This suggests that AD may cause spatial disorientation as a result of early tau accumulation in the parietal-hippocampal network.

scholarly journals Improved spatial learning and memory performance following Tualang honey treatment during cerebral hypoperfusion-induced neurodegeneration

2016 ◽  
Vol 2 (5) ◽  
pp. 264-271 ◽  
Author(s):  
Anil Kumar Saxena ◽  
Hnin P Phyu ◽  
Imad M Al-Ani ◽  
Oothuman P
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Performance ◽  
Cerebral Hypoperfusion ◽  
Spatial Learning And Memory ◽  
Tualang Honey

Alterations in spatial learning and memory after forced exercise

2007 ◽  
Vol 2007 ◽  
pp. 131-133
Author(s):  
R.J. Shephard
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory
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