EM.P.2.02 Secretion of the N-terminal domain of α-dystroglycan in the human cerebrospinal fluid in physiological and pathological conditions

2009 ◽  
Vol 19 (8-9) ◽  
pp. 552
Author(s):  
K. Matsumura ◽  
F. Saito ◽  
Y. Saito-Arai ◽  
M. Ikeda ◽  
A. Nakakmura ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Terminal Domain ◽  
Pathological Conditions ◽  
Human Cerebrospinal Fluid

CHOLINESTERASES OF CEREBROSPINAL FLUID: DATA FOR NORMAL FLUIDS AND FLUIDS FROM PATIENTS WITH SYPHILIS, MENINGITIS, OR POLIOMYELITIS

1949 ◽  
Vol 27e (6) ◽  
pp. 327-340 ◽  
Author(s):  
K. G. Colling ◽  
R. J. Rossiter
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Count ◽  
Protein Concentration ◽  
Cholinesterase Activity ◽  
Spinal Fluid ◽  
Diagnostic Aid ◽  
Pathological Conditions ◽  
Human Cerebrospinal Fluid ◽  
The Brain

In confirmation of the work of others it has been shown that the principal enzyme in human cerebrospinal fluid that can hydrolyze acetylcholine is true cholinesterase. There is in addition a lesser quantity of pseudocholinesterase. The true cholinesterase, but not the pseudocholinesterase, was found to be significantly increased in the spinal fluids of patients with syphilis, while the pseudocholinesterase, and not the true cholinesterase, was increased in the fluids of patients with either meningitis or poliomyelitis. The true cholinesterase activity was correlated neither with the protein concentration nor with the cell count, while the pseudocholinesterase was correlated with the protein concentration and less significantly with the cell count. When correction was made for the correlation between cell count and protein concentration, the correlation between pseudocholinesterase activity and protein concentration remained statistically significant, but that between pseudocholinesterase and cell count became of dubious significance. In pathological conditions it appears unlikely that either true cholinesterase or pseudocholinesterase is derived from the white cells in the fluid. It is possible that the increased pseudocholinesterase comes from the blood plasma as a result of an increase in the permeability of the "plasma–spinal fluid barrier" and that the increased true cholinesterase comes from the substance of the brain or spinal cord. For the pathological conditions studied, the determination of true and pseudocholinesterase activity of the spinal fluid would be of little value as a diagnostic aid.

Prostaglandin F2? levels in human cerebrospinal fluid in normal and pathological conditions

1980 ◽  
Vol 222 (4) ◽  
pp. 239-248 ◽  
Author(s):  
D. Egg ◽  
M. Herold ◽  
E. Rumpl ◽  
R. G�nther
Keyword(s):  
Cerebrospinal Fluid ◽  
Pathological Conditions ◽  
Human Cerebrospinal Fluid

scholarly journals Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins

1998 ◽  
Vol 39 (12) ◽  
pp. 2443-2451
Author(s):  
Kathleen S. Montine ◽  
Casey N. Bassett ◽  
Joyce J. Ou ◽  
William R. Markesbery ◽  
Larry L. Swift ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Apolipoprotein E ◽  
Human Cerebrospinal Fluid
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