Hydroxamic acid and fluorinated derivatives of valproic acid: Anticonvulsant activity, neurotoxicity and teratogenicity

2008 ◽  
Vol 30 (5) ◽  
pp. 390-394 ◽  
Author(s):  
Ute Gravemann ◽  
Jutta Volland ◽  
Heinz Nau
Keyword(s):  
Valproic Acid ◽  
Anticonvulsant Activity ◽  
Hydroxamic Acid ◽  
Fluorinated Derivatives ◽  
Derivatives Of

scholarly journals Effects of Ethyl Ester Derivatives of Valproic Acid Metabolites on Pentylenetetrazol Seizures in Mice

1981 ◽  
Vol 8 (3) ◽  
pp. 259-261 ◽  
Author(s):  
J. Bruni ◽  
E.J. Hammond ◽  
B.J. Wilder
Keyword(s):  
Valproic Acid ◽  
Ethyl Ester ◽  
Adult Male ◽  
Anticonvulsant Activity ◽  
Ethyl Esters ◽  
Icr Mice ◽  
Acid Metabolites ◽  
Pentylenetetrazol Seizures ◽  
Derivatives Of

SUMMARY:The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice. The ethyl ester 3-hydroxy-propylpentanoic acid was found to possess significant anticonvulsant activity.

Synthesis and Evaluation of Antiallodynic and Anticonvulsant Activity of Novel Amide and Urea Derivatives of Valproic Acid Analogues

2009 ◽  
Vol 52 (22) ◽  
pp. 7236-7248 ◽  
Author(s):  
Dan Kaufmann ◽  
Meir Bialer ◽  
Jakob Avi Shimshoni ◽  
Marshall Devor ◽  
Boris Yagen
Keyword(s):  
Valproic Acid ◽  
Anticonvulsant Activity ◽  
Urea Derivatives ◽  
Derivatives Of

Anticonvulsant Activity and 5-HT1A/5-HT7 Receptors Affinity of Piperazine Derivatives of 3,3-Diphenyl- and 3,3-Dimethyl-succinimides

2012 ◽  
Vol 10 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Jolanta Obniska ◽  
Iwona Chlebek ◽  
Krzysztof Kaminski ◽  
Andrzej J.Bojarski ◽  
Grzegorz Satala
Keyword(s):  
Anticonvulsant Activity ◽  
Piperazine Derivatives ◽  
Derivatives Of

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

Circadian variation in anticonvulsant activity of valproic acid in mice

2017 ◽  
Vol 95 ◽  
pp. 25-30 ◽  
Author(s):  
Wafa Ben Cherif Khedhaier ◽  
Ichrak Dridi ◽  
Karim Aouam ◽  
Mossadok Ben-Attia ◽  
Alain Reinberg ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Anticonvulsant Activity ◽  
Circadian Variation

scholarly journals Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio)pyrimidin-4(3 H)-one derivatives and products of their cyclization

Pharmacia ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 141-146
Author(s):  
Hanna Severina ◽  
Olga O. Skupa ◽  
Natalya I. Voloshchuk ◽  
Marharyta M. Suleiman ◽  
Victoriya A. Georgiyants
Keyword(s):  
Sulphuric Acid ◽  
Anticonvulsant Activity ◽  
Sodium Methoxide ◽  
Structure Activity ◽  
Phenacyl Bromides ◽  
Pharmacological Screening ◽  
High Yields ◽  
Derivatives Of

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one phenacyl bromides under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3 a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-one was formed. The holding of the resulting mixture in the concentrated sulphuric acid leads to the formation of cyclization products - derivatives of 3-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one with high yields. Individual S-alkylated derivatives – 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-one - were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacological screening of synthesized compounds for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “structure-activity” was established.

Synthesis of 1-Hydroxypyrrolidin-2,5-dione Derivatives of the Phosphonic - Hydroxamic Acid Antibiotic SF-2312

2006 ◽  
Vol 59 (4) ◽  
pp. 283 ◽  
Author(s):  
Wamuyu Owotoki ◽  
Detlef Geffken ◽  
Thomas Kurz
Keyword(s):  
Hydroxamic Acid ◽  
Phosphonic Acids ◽  
Trialkyl Phosphites ◽  
Derivatives Of ◽  
Substituted 1 ◽  
Ring Position

Analogues of the antibiotic SF-2312 with a 3-substituted 1-hydroxypyrrolidine moiety have been prepared from 1-benzyloxy-3-bromopyrrolidin-2,5-dione (1) through Michaelis–Arbusov reaction with various trialkyl phosphites and subsequent alkylation of ring position 3. Cleavage of phosphonic esters 3 by TMSBr afforded the corresponding phosphonic acids 7, which were treated with ethanolamine to give the monosalts 8. Finally, hydrogenolysis furnished 1-hydroxypyrrolidin-2,5-diones 9.

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