Correlations between 18F-FDG uptake by bone marrow and hematological parameters: measurements by PET/CT

While the diagnosis of adult-onset Still’s disease (AOSD) involves the exclusion of differential diagnoses, the characteristics and value of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography coupled with CT (PET/CT) in the management of AOSD remain poorly known. Our retrospective study included patients from four centers, fulfilling Yamaguchi or Fautrel criteria, who underwent a PET/CT during an active AOSD. Thirty-five patients were included. At the time of PET/CT, the Yamaguchi criteria were met in 23 of 29 evaluable cases. PET/CT showed bone marrow (74.3%), lymph node (74.3%), and splenic (48.6%) FDG uptake. Despite arthralgia or arthritis in most patients, joints were rarely the sites of 18F-FDG accumulation. The spatial distribution of 18F-FDG uptake was nonspecific, and its intensity could be similar to malignant disease. Lymph node or bone marrow biopsy was performed after PET/CT in 20 patients (57.1%). The intensity of bone marrow; splenic and lymph node hypermetabolism appeared to be correlated with disease activity. Abnormal PET/CT in the cervical lymph nodes and age ≥ 60 years seemed to be predictive factors for monocyclic evolution. The clinical value of PET/CT is not in direct diagnosis; but as an aid in excluding differential diagnoses by searching for their scintigraphic features and guiding biopsy.

Download Full-text

Quantitative, Dynamic 18F-FDG PET/CT in Monitoring of Smoldering Myeloma: A Case Report

Diagnostics ◽

10.3390/diagnostics11040649 ◽

2021 ◽

Vol 11 (4) ◽

pp. 649

Author(s):

Christos Sachpekidis ◽

Matthias Türk ◽

Antonia Dimitrakopoulou-Strauss

Keyword(s):

Bone Marrow ◽

Plasma Cells ◽

Autologous Transplantation ◽

Standardized Uptake Value ◽

Focal Lesions ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Smoldering Myeloma

We report on a 52-year-old patient with an initial diagnosis of smoldering myeloma (SMM), who was monitored by means of dynamic and static positron emission tomography/computed tomography (PET/CT) with the radiotracer 1⁸F-fluorodeoxyglucose (18F-FDG). Baseline PET/CT revealed no pathological signs. Six months later, a transition to symptomatic, multiple myeloma (MM) was diagnosed. The transition was not accompanied by focal, hypermetabolic lesions on PET/CT. However, a diffusely increased 18F-FDG uptake in the bone marrow, accompanied by a marked increase of semi-quantitative (standardized uptake value, SUV) and quantitative, pharmacokinetic 18F-FDG parameters, was demonstrated. After successful treatment, including tandem autologous transplantation, the diffuse uptake in the bone marrow as well as the semi-quantitative and quantitative parameters showed a marked remission. This response was also confirmed by the clinical follow-up of the patient. These findings suggest that in MM a diffuse 18F-FDG uptake in the bone marrow may indeed reflect an actual bone marrow infiltration by plasma cells. Moreover, SUV values and kinetic parameters, not only from myeloma lesions but also from random bone marrow samples, may be used for MM monitoring. This could be particularly helpful in the follow-up of myeloma patients negative for 18F-FDG-avid focal lesions.

Download Full-text

Focal 18F-FDG uptake in bone marrow on PET/CT in a patient with JAK2 mutation without overt myeloproliferative neoplasm

International Journal of Hematology ◽

10.1007/s12185-013-1473-y ◽

2013 ◽

Vol 99 (1) ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Akihito Fujimi ◽

Yuji Kanisawa ◽

Shinya Minami ◽

Yusuke Kamihara ◽

Sari Iwasaki

Keyword(s):

Bone Marrow ◽

Myeloproliferative Neoplasm ◽

Jak2 Mutation ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg

Download Full-text

Diffusely Increased Bone Marrow 18F-FDG Uptake Is an Independent Predictor of Focal Bone Lesions in Patients with Newly Diagnosed Classical Hodgkin Lymphoma

Blood ◽

10.1182/blood.v124.21.5360.5360 ◽

2014 ◽

Vol 124 (21) ◽

pp. 5360-5360

Author(s):

Lars C. Gormsen ◽

Cecilia Wassberg ◽

Daniel Molin ◽

Peter Kamper ◽

Gunilla Enblad ◽

...

Keyword(s):

Bone Marrow ◽

Logistic Regression ◽

Independent Predictor ◽

Bone Lesions ◽

Classical Hodgkin Lymphoma ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

The Relationship ◽

Initial Staging

Abstract Background: 18F-FDG PET/CT is recommended in the initial staging of patients with classical Hodgkin lymphoma (cHL). Whereas focal 18F-FDG uptake in the skeleton is considered to represent bone involvement, it is still unclear whether diffusely increased 18F-FDG bone marrow uptake (BMU) indicates lymphoma infiltration or merely reflects a state of general inflammation. This retrospective study was therefore performed to study the relationship between pre-therapeutic (PET0) 18F-FDG BMU and the presence of focal bone lesions. Methods: A total of 139 patients (median age 44, range 8-83) referred to PET/CT between 2008 and 2014 for HL staging were included. All PET0 and post-therapeutic (PET2) images were reviewed and evidence of focal bone lesions was recorded (unifocal: ≤2 lesions, multifocal: >2 lesions). In addition, 18F-FDG uptake (SUVmax) was semiquantitatively measured in the vertebral bone marrow (SUVvertebra) and in the right lobe of the liver (SUVliver). BMU was calculated as SUVvertebra/SUVliver. The relationship between focal bone lesions on PET0 and BMU as well as age was subsequently analysed by logistic regression. Results: In total 30/139 (22 %) patients had focal bone lesions at initial staging (10 unifocal, 20 multifocal). BMU at initial presentation was generally increased in all patients when compared with the post-therapeutic PET/CT (PET0: 1.22 +/- 0.03 vs. PET2: 0.95 +/- 0.03, p<0.001). In a logistic regression model diffusely increased BMU at PET0 (p=0.01) as well as age (p=0.01) were both independent predictors of focal bone lesions. Conclusion: Diffusely increased 18F-FDG uptake is an independent predictor of skeletal bone lesions in patients with HL. Evidence of increased BMU might be evaluated as an additional outcome predictor in the pre-therapeutic risk assessment of patients with HL. With the purpose of validating these findings, we will analyze an independent cohort of Swedish cHL patients and joined data from both cohorts will be presented at the meeting. Disclosures No relevant conflicts of interest to declare.

Download Full-text

Physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging

Acta Radiologica ◽

10.1177/0284185118762245 ◽

2018 ◽

Vol 59 (12) ◽

pp. 1487-1493 ◽

Cited By ~ 3

Author(s):

Guohua Shen ◽

Meng Liang ◽

Minggang Su ◽

Anren Kuang

Keyword(s):

Bone Marrow ◽

Vertebral Body ◽

Cervical Vertebrae ◽

Healthy Adults ◽

Physiological Uptake ◽

Vertebral Bone ◽

Fdg Uptake ◽

Pet Ct ◽

Vertebral Bone Marrow ◽

18F Fdg

Background 18F-fluorodeoxyglucose *Equal contributors. positron emission tomography/computed tomography (18F-FDG PET/CT) has proven to be a valuable imaging modality for the assessment of bone marrow condition. Purpose To investigate the physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging, and correlate the appearance with clinical factors including gender, body mass index, and age. Material and Methods A total of 64 healthy individuals underwent PET/CT scan, and for each vertebral body, the mean and maximum standardized uptake value (SUVmean and SUVmax) were determined in the central slice of vertebral body on the transversal fused PET/CT image. For each individual, the FDG uptake of the four regions was obtained by averaging the SUVmean and SUVmax of the vertebrae in individual regions. Results The FDG uptake from thoracic to sacral vertebrae showed an upward trend first, then a downward trend, while that of cervical vertebrae was relatively stable. The SUVmax and SUVmean values of bone marrow in the old group (age ≥ 50 years) were significantly lower than those in the young group (age < 50 years) in all regions of the spine ( P < 0.05). FDG uptake of the whole spine showed significant negative correlation with age, and the strongest correlation was observed in lumbar spine (SUVmean: r = −0.364, P < 0.05; SUVmax: r = −0.344, P < 0.05). Conclusion FDG uptake showed a tendency to increase first then decrease from thoracic to sacral vertebrae while the tendency was not obvious in cervical vertebrae. In addition, the glycolytic metabolism of all the four regions decreased with advancing age.

Download Full-text

A predicting model of bone marrow malignant infiltration in 18F-FDG PET/CT images with increased diffuse bone marrow FDG uptake

Journal of Cancer ◽

10.7150/jca.24836 ◽

2018 ◽

Vol 9 (10) ◽

pp. 1737-1744 ◽

Cited By ~ 2

Author(s):

Mingge Zhou ◽

Yumei Chen ◽

Jianjun Liu ◽

Gang Huang

Keyword(s):

Bone Marrow ◽

Fdg Pet ◽

Ct Images ◽

Predicting Model ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Download Full-text

[18F]FDG uptake of bone marrow on PET/CT for predicting distant recurrence in breast cancer patients after surgical resection

EJNMMI Research ◽

10.1186/s13550-020-00660-y ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Jeong Won Lee ◽

Sung Yong Kim ◽

Sun Wook Han ◽

Jong Eun Lee ◽

Hyun Ju Lee ◽

...

Keyword(s):

Breast Cancer ◽

Bone Marrow ◽

Cancer Patients ◽

Surgical Resection ◽

Distant Recurrence ◽

Breast Cancer Patients ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg

Download Full-text

18F-FDG Uptake on PET/CT in Transposed Ovaries

American Journal of Roentgenology ◽

10.2214/ajr.06.5004 ◽

2006 ◽

Vol 186 (1) ◽

pp. 267-268 ◽

Cited By ~ 2

Author(s):

R. Zissin ◽

E. Even-Sapir

Keyword(s):

Fdg Uptake ◽

Pet Ct ◽

18F Fdg

Download Full-text

Impacts of time interval on 18F-FDG uptake for PET/CT in normal organs

Medicine ◽

10.1097/md.0000000000013122 ◽

2018 ◽

Vol 97 (45) ◽

pp. e13122 ◽

Cited By ~ 3

Author(s):

Rang Wang ◽

Haotian Chen ◽

Chengzhong Fan

Keyword(s):

Time Interval ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg

Download Full-text

Long-Term Follow-Up of Thyroid Incidentalomas Visualized with 18F-Fluorodeoxyglucose Positron Emission Tomography—Impact of Thyroid Scintigraphy in the Diagnostic Work-Up

Diagnostics ◽

10.3390/diagnostics11030557 ◽

2021 ◽

Vol 11 (3) ◽

pp. 557

Author(s):

Kirsten Korsholm ◽

Michala Reichkendler ◽

Louise Alslev ◽

Åse Krogh Rasmussen ◽

Peter Oturai

Keyword(s):

Emission Tomography ◽

Thyroid Scintigraphy ◽

Fdg Uptake ◽

Positron Emission ◽

Pet Ct ◽

18F Fdg ◽

Diagnostic Work ◽

Fdg Pet Ct ◽

Work Up ◽

Diagnostic Work Up

Our objective was to evaluate the frequency of malignancy in incidental thyroidal uptake on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in a cohort of Danish patients, and furthermore to evaluate the impact of thyroid scinti-graphy in the diagnostic work-up. All whole-body PET/CT reports from 1 January 2010 to 31 December 2013 were retrospectively reviewed and further analyzed if visually increased thyroidal FDG uptake was reported. Patient electronic files were searched for further thyroid evaluation. Of 13,195 18F-FDG-PET/CT scans in 9114 patients, 312 PET/CT reports mentioned incidental thyroid FDG-uptake, and 279 patients were included in the study (3.1%). The thyroid was further investigated in 137 patients (49%), and 75 patients underwent thyroid scintigraphy. A total of 57 patients had a thyroid biopsy and 21 proceeded to surgery. Surgical specimens displayed malignancy in 10 cases, and one thyroid malignancy was found by autopsy. Hence, 11 patients were diagnosed with thyroid malignancies among 279 patients with incidental thyroid 18F-FDG uptake (3.9%). In 34 patients, a biopsy was avoided due to the results of the thyroid scintigraphy. We conclude that patients with thyroid incidentalomas can benefit from further diagnostic work-up including a thyroid scintigraphy.

Download Full-text