Consumption of a liquid high-fat meal increases triglycerides but decreases high-density lipoprotein cholesterol in abdominally obese subjects with high postprandial insulin resistance

2017 ◽  
Vol 43 ◽  
pp. 82-88 ◽  
Author(s):  
Feng Wang ◽  
Huixia Lu ◽  
Fukang Liu ◽  
Huizhen Cai ◽  
Hui Xia ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
High Fat ◽  
Obese Subjects ◽  
Postprandial Insulin ◽  
Fat Meal

scholarly journals Triglycerides to High-density Lipoprotein Cholesterol Ratio is the Best Surrogate Marker for Insulin Resistance in Non-obese Middle-aged and Elderly Population: A Cross-sectional Study

2020 ◽  
Author(s):  
Yumei Yang ◽  
Baomin Wang ◽  
Haoyue Yuan ◽  
Xiaomu Li
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Obese Subjects

Abstract BackgroundInsulin resistance is closely associated with metabolic profiles, including obesity and dyslipidemia. However, there are few studies to demonstrate a relationship between lipid profiles and insulin resistance, categorized by BMI, especially in Chinese. The aim of the present study was to examine how lipid profiles were associated with insulin resistance in non-obese middle-aged and elderly Chinese population.MethodsThis cross-sectional study included 1608 (596 men and 1012 women) subjects, without prior known diabetes mellitus and lipid regulating therapy history, older than 45 years. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. The areas under the curve of the receiver operating characteristic curves (AROC) were used to compare the power of these serum markers. SPSS 17.0 software was used for the statistical analysis.ResultsIn non-obese subjects (BMI < 25 kg/m2, n= 996), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (OR = 1.43, 95% CI 1.13-1.81, P = 0.003), and SBP (OR = 1.01, 95% CI 1.00-1.02, P = 0.03) were independently risk factors for the insulin resistance. The best marker for insulin resistance in non-obese subjects was triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio with the AROC of 0.73 (95% CI 0.68-0.77, P < 0.001), and the positive likelihood ratio was greatest for TG/HDL-C ratio in the metabolic profiles including BMI. The optimal cut-off point to identifying insulin resistance for TG/HDL-C ratio was ≥ 1.50 in the non-obese population. The BMI, TG, total cholesterol (TC)/HDL-C ratio and HDL-C also discriminated insulin resistance, as the values for AROC were 0.70 (95% CI 0.66-0.75, P < 0.001), 0.71 (95% CI 0.67-0.76, P < 0.001), 0.70 (95% CI 0.65-0.74, P < 0.001), 0.34 (95% CI 0.29-0.38, P < 0.001), respectively. In overweight subjects (BMI ≥ 25.0 kg/m2, n = 612), BMI was still the best marker for insulin resistance with the AROC of 0.65 (95% CI 0.60-0.69, P < 0.001). ConclusionsTG/HDL-C ratio may be the best reliable marker for insulin resistance in the non-obese population.

Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy

2018 ◽  
Vol 10 (46) ◽  
pp. 5493-5498
Author(s):  
Zhigang Li ◽  
Xifa Lan ◽  
Xiaoxiao Jiang ◽  
Qiaoyun Wang ◽  
Zhenhe Ma ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
Ft Raman Spectroscopy ◽  
Atr Spectroscopy ◽  
Ft Raman

The triglyceride (TG) to high density lipoprotein cholesterol ratio (TG/HDL-C) and the TG level itself have both been identified as a biomarker of insulin resistance, cardiovascular disease and a predictor for atherosclerosis.

scholarly journals Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Joungyoun Kim ◽  
Sang-Jun Shin ◽  
Ye-Seul Kim ◽  
Hee-Taik Kang
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
National Health ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Korean Adults ◽  
Onset Diabetes ◽  
New Onset

Abstract Background Insulin resistance is associated with the incidence of diabetes and cardiovascular diseases such as myocardial infarction. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is positively correlated with insulin resistance. This study aimed to investigate the relationship between the TG/HDL-C ratio and the incidence of diabetes in Korean adults. Methods This retrospective study used data from the National Health Insurance Service-National Health Screening Cohort. The TG/HDL-C ratio was divided into three tertiles, the T1, T2, and T3 groups, based on sex. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes using multivariate Cox proportional hazards regression analyses. Results A total of 80,693 subjects aged between 40 and 79 years were enrolled. The median follow-up period was 5.9 years. The estimated cumulative incidence of diabetes in the T1, T2, and T3 groups was 5.94%, 8.23%, and 13.50%, respectively, in men and 4.12%, 4.72%, and 6.85%, respectively, in women. Compared to T1, the fully adjusted HRs (95% CIs) of the T2 and T3 groups for new-onset diabetes were 1.17 (1.06–1.30) and 1.47 (1.34–1.62), respectively, in men and 1.20 (1.02–1.42) and 1.52 (1.30–1.78), respectively, in women. Conclusions Increased TG/HDL-C ratio was significantly associated with a higher risk of new-onset diabetes in both sexes.

Association of the Triglyceride/High-Density Lipoprotein Cholesterol Index with Insulin Resistance in a Pediatric Population in Northeast Mexico

2020 ◽  
Vol 18 (7) ◽  
pp. 333-340
Author(s):  
Nora Rodríguez-Gutiérrez ◽  
Mariana Vanoye Tamez ◽  
Eduardo Vázquez-Garza ◽  
José R. Villarreal-Calderón ◽  
Elena C. Castillo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Pediatric Population ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol
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